Baclosan - instructions for use, reviews, analogs and forms of release (10 mg and 25 mg tablets) drugs for the treatment of multiple sclerosis, dsp and stroke in adults, children and pregnancy. Overdose and interaction with alcohol

In this article, you can read the instructions for using the drug Baklosan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Baklosan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Baklosan in the presence of existing structural analogues. Use for the treatment of multiple sclerosis, dsp and stroke in adults, children,as well as during pregnancy and lactation. Overdose and drug interaction with alcohol.

Baklosan - Muscle relaxant of central action; agonist of GABA receptors. Reducing the excitability of the end sections of the afferent sensitive fibers and suppressing the intermediate neurons, inhibits the mono- and polysynaptic transmission of nerve impulses; reduces the preliminary stress of the muscle spindles. Does not affect the transfer of impulses in neuromuscular synapses. With neurological diseases accompanied by spasticity of skeletal muscles, it alleviates painful spasms and clonic convulsions. Increases the volume of movement in the joints, facilitates the conduct of passive and active kinesitherapy (physical exercises, massage, manual therapy).

Composition

Baclofen + auxiliary substances.

Pharmacokinetics

After oral administration, Baclosan is rapidly and completely absorbed from the digestive tract. Binding to plasma proteins is about 30%. Baclofen penetrates the placental barrier, excreted in breast milk. Metabolised in the liver. It is excreted in the urine, mostly unchanged.

Indications

Increased muscle tone:

• with multiple sclerosis;
• with diseases of the spinal cord of infectious, degenerative and traumatic genesis (for example, tumors, syringomyelia, motor neuron diseases, trauma);
• with stroke;
• in infantile cerebral palsy;
• with meningitis;
• with craniocerebral injuries;
• at an alcoholism (affective frustration).

Forms of release

Tablets 10 mg and 25 mg.

Instructions for use and dosing regimen

Install individually.

Adults prescribe the drug in an initial dose of 5 mg 3 times a day; gradually every 3 days increase the dose to develop the optimal therapeutic effect (usually up to 30-75 mg per day). Patients who require the use of the drug in higher doses (usually up to 30-75 mg per day), Baclosan is prescribed in tablets of 25 mg each. The maximum daily dose is 100 mg.

In patients over the age of 65, the dose should be increased with caution in connection with an increased risk of side effects.

The initial single dose of the drug for children is 5 mg, the frequency of intake 3 times a day. If necessary, carefully increase the dose every 3 days. Average recommended doses are for children aged 1 to 2 years - 10-20 mg per day, from 2 to 6 years - 20-30 mg per day, from 6 to 10 years - 30-60 mg per day.In children older than 10 years, the maximum daily dose is determined from the calculation of 1.5-2 mg / kg body weight.

The drug is taken with food. If you miss a regular dose, you should not take a double dose of the drug.

Side effect

• drowsiness;
• dizziness;
• violation of gait;
• increased fatigue;
• confusion of consciousness;
• apathy;
• euphoria;
• depression;
• paresthesia;
• tremor;
• hallucinations;
• convulsions;
• decreased convulsive threshold;
• nausea, vomiting;
• dry mouth;
• constipation;
• diarrhea;
• retention of urine;
• dysuria;
• enuresis;
• impaired renal function;
• a decrease in blood pressure;
• myalgia;
• muscle weakness.

Contraindications

• psychoses;
• Parkinson's disease;
• epilepsy;
• convulsions (in the anamnesis);
• chronic renal failure;
• pregnancy;
• lactation (breastfeeding);
• hypersensitivity to baclofen.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Application in elderly patients

With caution appoint the drug to elderly patients.

Use in children

With caution appoint the drug to children under the age of 12 years.

special instructions

In patients with liver disease and diabetes mellitus, it is necessary to periodically monitor the activity of hepatic transaminases and alkaline phosphatase, as well as glucose in the blood.

It is released by prescription.

With caution appoint a drug for cerebrovascular insufficiency, cerebral artery atherosclerosis, in patients with peptic ulcer of the stomach and duodenum, elderly patients, children under 12 years of age.

Impact on the ability to drive vehicles and manage mechanisms

Patients taking Baclosan should refrain from potentially dangerous activities associated with the need for increased attention and rapid psychomotor reactions.

Overdose

Symptoms: muscle hypotension, oppression of the respiratory center, confusion, coma (after the return of consciousness, muscle hypotension may persist for 72 hours).

Treatment: plentiful drink, reception of diuretics, at oppression of breath - IVL. There is no specific antidote.

Drug Interactions

With the simultaneous use of Baclosan enhances the effect of drugs that affect the central nervous system, hypotensive drugs, ethanol (alcohol).

With the simultaneous use of baclosan with tricyclic antidepressants, a significant decrease in muscle tone is possible.

In patients with Parkinson's disease with simultaneous administration of Baklosan with levodopa and carbidopa, hallucinations, confusion, and arousal can occur.

Analogues of the drug Baclossan

Structural analogs for the active substance:

• Baclofen;
• Liorasal Intrathecal.

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