Macropen - instructions for use, analogs, reviews and release forms (granules for the preparation of suspension, tablets 400 mg) of a drug for the treatment of angina, sinusitis and other infections in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Macropen. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Macropen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Macropene in the presence of existing structural analogs. Use for the treatment of angina, sinusitis and other infectious diseases in adults, children,as well as during pregnancy and lactation. Composition of the preparation.
Macropen - antibiotic group of macrolides. Inhibits the synthesis of proteins in bacterial cells. Reversibly binds to the 50S subunit of the ribosomal membrane of bacteria. In low doses the drug has a bacteriostatic effect, in high - bactericidal.
It is active against intracellular microorganisms: Mycoplasma spp., Chlamydia spp., Legionella spp., Ureaplasma urealyticum; Gram-positive and Gram-negative bacteria.
Composition
Midekamycin + excipients.
Pharmacokinetics
After oral administration, Macropen quickly and fairly completely absorbed from the digestive tract. High concentrations of meadecamycin and midecamycin acetate are created in internal organs (especially in lung tissue, parotid and submaxillary glands) and skin. Midekamycin is excreted with bile and to a lesser extent (about 5%) with urine.
Indications
Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation:
- respiratory infections: tonsillopharyngitis, acute otitis media, sinusitis, exacerbation of chronic bronchitis, community-acquired pneumonia (including those caused by atypical pathogens Mycoplasma spp., Chlamydia spp., Legionella spp.and Ureaplasma urealyticum);
- infections of the genitourinary system caused by Mycoplasma spp., Chlamydia spp., Legionella spp. and Ureaplasma urealyticum;
- infections of the skin and subcutaneous tissue;
- treatment of enteritis caused by Campylobacter spp .;
- treatment and prevention of diphtheria and pertussis.
Forms of release
Film-coated tablets 400 mg.
Granules for the preparation of a suspension for oral administration (ideal pediatric form).
Instructions for use and dosage
The drug should be taken before meals.
Adults and children with a body weight of more than 30 kg Makropen appoint 400 mg (1 tablet) 3 times a day. The maximum daily intake for adults is 1.6 g.
For children weighing less than 30 kg, the daily dose is 20-40 mg / kg of body weight in 3 divided doses or 50 mg / kg of body weight in 2 divided doses, in severe infections 50 mg / kg of body weight in 3 divided doses.
Scheme of application Macrofen in the form of a suspension for children (daily dose of 50 mg / kg of body weight in 2 divided doses) is presented below:
- up to 5 kg (about 2 months) - 3.75 ml (131.25 mg) 2 times a day;
- up to 10 kg (about 1-2 years) - 7.5 ml (262.5 mg) 2 times a day;
- up to 15 kg (about 4 years) - 10 ml (350 mg) twice a day;
- up to 20 kg (about 6 years) - 15 ml (525 mg) twice a day;
- up to 30 kg (about 10 years) - 22.5 ml (787.5 mg) 2 times a day.
Duration of treatment is from 7 to 14 days, with the treatment of chlamydial infections - 14 days.
In order to prevent diphtheria, the drug is prescribed at a dose of 50 mg / kg per day, divided into 2 doses, for 7 days. Recommended control bacteriological study after the termination of therapy.
For the prevention of whooping cough, the drug is prescribed at a dose of 50 mg / kg per day for 7-14 days in the first 14 days from the moment of contact.
To prepare the suspension, add 100 ml of boiled or distilled water to the contents of the vial and shake well. Before use, the prepared suspension should be shaken.
Side effect
- decreased appetite;
- stomatitis;
- nausea, vomiting;
- diarrhea;
- feeling of heaviness in epigastrium;
- increased activity of hepatic transaminases and jaundice;
- severe and prolonged diarrhea, which may indicate the development of pseudomembranous colitis;
- skin rash;
- hives;
- itching;
- eosinophilia;
- bronchospasm;
- weakness.
Contraindications
- hepatic failure of severe degree;
- children under 3 years (for tablets);
- increased sensitivity to midecamycin / midecamycin acetate and other components of the drug.
Application in pregnancy and lactation
Application of Macrofene during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.
Meadecamycin excreted in breast milk. When using Macropene during lactation, breastfeeding should be discontinued.
Use in children under 12 years of age
The drug is used according to the indications, in the recommended dosage form and in doses taking into account the age of the patients.
special instructions
As with any other antimicrobial drugs, with prolonged therapy with Macropen, excessive growth of resistant bacteria is possible. Prolonged diarrhea can indicate the development of pseudomembranous colitis.
With prolonged therapy, hepatic enzyme activity should be monitored, especially in patients with impaired hepatic function.
Mannitol contained in granules for the preparation of a suspension can cause diarrhea.
If there is an allergic reaction to the reception of acetylsalicylic acid, the azo dye E110 (dye sunset yellow) can cause an allergic reaction up to the bronchospasm.
Impact on the ability to drive vehicles and manage mechanisms
It was not reported about the influence of Macropen on the speed of psychomotor reactions and the ability to drive and other mechanisms.
Drug Interactions
With the simultaneous application of Macrofene with ergot alkaloids, carbamazepine, their metabolism in the liver decreases and serum concentration increases. Therefore, with the simultaneous administration of these drugs should be careful.
With the simultaneous use of Macropen with cyclosporine, anticoagulants (warfarin), slowing down the latter.
Macropen does not affect the pharmacokinetic parameters of theophylline.
Analogues of the drug Macropen
The drug has no structural analogs for the active ingredient.
Analogues for the pharmacological group (Macrolides and azalides):
- Azivok;
- Azimycin;
- Azitral;
- Azitroxy;
- Azithromycin;
- AsitRus;
- Azicid;
- Arvitsin;
- Arvitsin retard;
- Benzamycin;
- Binocular;
- Brilid;
- Wilprafen;
- Wilprafen solute;
- Grunamycin syrup;
- Dynabac;
- Zetamax retard;
- Zimbactur;
- Zitnob;
- Zitrolide;
- Zitrocin;
- Ilozon;
- Kispar;
- Klabaks;
- Clarcat;
- Clarithromycin;
- Clarithrosine;
- Claricin;
- Claricite;
- Claromin;
- Class;
- Clacid;
- Clerimedes;
- Coater;
- Crixan;
- Xitrocin;
- Oleandomycin phosphate;
- Rovamycin;
- Roxid;
- Roxilor;
- Roximizane;
- Roxithromycin;
- Rulid;
- Rulicin;
- Sumazid;
- Sumaclide;
- Sumamed;
- Sumamed forte;
- Sumamecin;
- Sumamecin forte;
- Sumamox;
- Sumatrolide solute;
- Fromromide;
- Hemomycin;
- Ecositrin;
- Ecomed;
- Elrox;
- Erythromycin;
- Eryfluid;
- Hermitage;
- Esparoxy.
Similar medicines:
Other medicines:
- Persen - instructions for use, reviews, analogs and forms of release (tablets and capsules forte soothing) for the treatment of excitability, irritability and insomnia in adults, children and pregnancy. Composition
- Fortrans - instructions for use, reviews, analogs and formulations (powder for the preparation of solution) laxative medicine for bowel cleansing (preparation for surgery and diagnosis) and weight loss in adults, children and pregnancy
- Cialis - instructions for use, reviews, generics and dosage forms (tablets of 2.5 mg, 5 mg and 20 mg) of the drug for the treatment of erectile dysfunction and restoration of potency in men. The composition and effect of alcohol on the pharmacokinetics