Tardiferon - instructions for use, analogs, reviews and release forms (prolonged-action tablets, Gino-Tardiferon) drug for the treatment of iron deficiency and iron deficiency anemia in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Tardiferon. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Tardiferon in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tardiferon and Gino-Tardiferon in the presence of existing structural analogues.Use for the treatment of iron deficiency and iron deficiency anemia in adults, children, as well as during pregnancy and lactation.

Tardiferon - anti-anemic drug, the effect of which is due to the properties of the components that make up its composition.

Iron sulfate is a salt of iron, a microelement necessary for the synthesis of hemoglobin. Iron is a part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, tenderness and dry skin) and laboratory symptoms of anemia.

Mucoproteosis provides better tolerability of the drug and increases bioavailability and gradual release of ferrous iron (Fe2 +) from the drug.

Ascorbic acid improves the absorption of iron.

Folic acid (in the drug Gino Tardiferon) is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline.When pregnancy protects the body from the effects of teratogenic factors.

A special neutral shell of the tablets ensures the absorption of active components, mainly in the distal part of the small intestine. The absence of local irritant effect on the gastric mucosa promotes good tolerability of the drug from the gastrointestinal tract.

Composition

Iron sulfate + excipients (Tardiferon).

Iron sulphate hydrate + Folic acid (vitamin Bc) + excipients (Gino-Tardiferon).

Pharmacokinetics

After taking the drug, iron is absorbed from the digestive tract. Bioavailability of iron is 10-30%. The gradual release of iron allows prolonging its absorption, mainly in the distal part of the small intestine. Folic acid is absorbed mainly from the upper parts of the digestive tract (duodenum). Binding of iron with plasma proteins - 90% or more. Deposited in the form of ferritin or hemosiderin in the cells of the phagocytic macrophage system, a small amount - in the form of myoglobin in the muscles. The binding of folic acid with plasma proteins is 64%; biotransformation occurs in the liver.Iron is excreted with feces, urine and sweat. Folic acid is excreted mainly by the kidneys, in part through the intestine.

Indications

• treatment and prevention of iron deficiency conditions of various etiologies (including during pregnancy and lactation, a decrease in iron absorption from the gastrointestinal tract, with prolonged bleeding, inadequate and unbalanced nutrition).

Forms of release

Tablets of prolonged action (retard), covered with sugar shell (Tardiferon and Gino-Tardiferon).

Other dosage forms, whether drops or solution at the time of publication of the drug in the Directory did not exist.

Instructions for use and dosage

Tardiferon

Adults and children over 6 years of age: tablets are taken orally (without chewing). It is advisable to take the drug with water, before meals or during meals. Use for medicinal purposes: children over 6 years - 1 tablet per day, children over 10 years and adults - 1-2 tablets per day.

Use for preventive purposes: pregnant women - 1 tablet a day or every other day during the last two trimesters of pregnancy (or starting from the 4th month).

Duration of admission

Adult patients should take the drug for a period that ensures correction of anemia and restoration of the iron reserve in the body. The dose for women is 600 mg, for men 1200 mg.

With iron deficiency anemia, the duration of admission is 3 to 6 months, depending on the degree of depletion of the iron reserve: if necessary, in the absence of adequate control of anemia, it is necessary to increase the duration of the drug intake.

Gino Tardiferon

With mild anemia, the drug is prescribed 1 tablet a day before breakfast; with a moderate anemia - 1 tablet 2 times a day; with severe anemia - 1 tablet 3 times a day for several weeks (on average 4-5 weeks) - until the normal level of hemoglobin is restored. After the normal level of hemoglobin is restored, the drug should be taken 2-3 months to replenish the iron stores.

For the prevention of iron deficiency and folic acid during pregnancy and lactation, the drug is prescribed 1 tablet per day in the 2nd and 3rd trimesters and the postpartum period during lactation.

Side effect

• nausea;
• pain in epigastrium;
• diarrhea, constipation.

Contraindications

• anemia not related to deficiency of iron or folic acid (hemolytic anemia, megaloblastic anemia associated with an isolated vitamin B12 deficiency);
• elevated iron content in the body (hemosiderosis);
• violation of mechanisms of iron utilization (anemia caused by lead poisoning, sidero-achestic anemia);
• fructose intolerance, glucose and galactose absorption impairment syndrome, invertase / isomaltase deficiency syndrome;
• stenosis of the esophagus and / or obstructive changes in the gastrointestinal tract;
• children's age (under 6 years for Tardifiron and under 18 for Gino-Tardiferon);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Tardiferone tablets are used for preventive purposes: pregnant women - 1 tablet a day or every other day for the last two trimesters of pregnancy (or starting from the 4th month).

For the prevention of iron deficiency and folic acid during pregnancy and lactation, the Gino Tardiferone preparation is prescribed 1 tablet per day in the 2nd and 3rd trimesters and the postpartum period during lactation.

Use in children

Tardiferon is contraindicated in children under 6 years of age.Children older than 6 years: tablets are taken orally (without chewing). It is advisable to take the drug with water, before meals or during meals. Use for medicinal purposes: children over 6 years - 1 tablet a day, children over 10 years - 1-2 tablets per day.

Gino Tardiferon is contraindicated in children and adolescents under the age of 18 years.

special instructions

Before starting therapy with the drug it is necessary to determine the content of iron and ferritin in the blood serum.

In the period of taking the drug must take into account that coffee, milk, vegetables, cereals reduce the absorption of iron.

During the period of taking the drug, a dark colouration of the stool can be observed, which is due to the removal of not absorbed iron and has no clinical significance.

With caution should take the drug for inflammatory bowel disease, alcoholism, liver or kidney failure.

Due to the presence of sucrose in the formulation, it is contraindicated for its use by individuals with fructose intolerance, glucose absorption and galactose disruption syndrome, or invertase / isomaltase deficiency syndrome (rare metabolic disorders).

Drug Interactions

Reduce iron absorption:

• antacid medicines containing salts of aluminum, calcium, magnesium, calcium preparations, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine);
• medicines containing carbonates, hydrogen carbonates, phosphates, oxalates;
• pancreatin, pancreolipase.

Mutually reduce absorption when combined:

• tetracyclines, D-penicillamine, tea, egg yolk.

If necessary, combining with the above drugs or foods, iron preparations should be taken 1 hour before or 2 hours after they are consumed.

Increase absorbability:

• ascorbic acid, ethanol (alcohol) (including increases the risk of toxic complications).

Iron drug in high doses reduces the absorption of zinc.

Do not administer together with other iron preparations, incl. for parenteral use, to avoid an overdose.

Analogues of the drug Tardiferon

Structural analogs for the active substance:

• Hemofer prolongatum;
• Gino-Tardiferon;
• Ferrogradumet.

Analogues on the curative effect (remedies for the treatment of iron deficiency):

• Actyferrin;
• Aktiferrin compositum;
• Biovital;
• Biofer;
• Venofer;
• Vitrum Superstress;
• Vitrum Cirkus;
• Hemofer;
• Gino-Tardiferon;
• CosmoFer;
• Likferr 100;
• Maltofer;
• Maltofer Foul;
• Mirazenova;
• Monofer;
• Pikovit Unik;
• Sideral Forte;
• Sorbifer Durules;
• Special Merz sweets;
• Stress formula with iron;
• Supradin Kids Junior;
• Totem;
• Fenyuls;
• Ferlatum;
• Ferlatum Foul;
• Ferretab;
• Ferrinate;
• Ferro Folgamma;
• Ferrograduum;
• Ferronal;
• Ferroplex;
• Ferrum Lek;
• Heferol;
• Enfamil Premium 2;
• Enfamil with iron.

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