Valsartan - instructions for use, analogs, reviews and release forms (tablets or capsules 20 mg, 40 mg, 80 mg, 160 mg) drugs for the treatment of hypertension and depression, heart failure in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Valsartan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Valsartan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Valsartan in the presence of existing structural analogues.Use to treat hypertension and reduce blood pressure, heart failure in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Valsartan antihypertensive agent. It is a specific antagonist of angiotensin receptors 2. It has a selective antagonistic effect on AT1 receptors, which are responsible for the realization of the effects of angiotensin 2.

Due to the blockade of AT1 receptors, the plasma concentration of angiotensin 2 increases, which can stimulate unblocked AT2 receptors. Has no agonistic activity against AT1 receptors. The affinity of valsartan for AT1 receptors is about 20,000 times higher than that of AT2 receptors.

Does not inhibit ACE. It does not interact and does not block the receptors of other hormones or ion channels, which are important for the regulation of the functions of the cardiovascular system. Has no effect on the level of total cholesterol, TG, glucose and uric acid in the blood plasma.

The onset of antihypertensive action of valsartan after its administration inwards in a single dose is observed within 2 hours after administration, the maximum effect is achieved within 4-6 hours.

Composition

Valsartan + excipients.

Pharmacokinetics

After oral administration valsartan is rapidly absorbed from the digestive tract, the degree of absorption is characterized by individual differences. Absolute bioavailability averages 23%. With the course application of changes in pharmacokinetic parameters were not noted. When taking valsartan with food, AUC is reduced by 48%, with about 8 hours after taking valsartan in plasma are the same in patients who took it with food and fasting. The decrease in AUC is not accompanied by a clinically significant decrease in the therapeutic effect. When taking valsartan once a day, the cumulation is not very pronounced. The concentrations of valsartan in the blood plasma in women and men were the same. The binding with plasma proteins, mainly with albumins, is 94-97%. It is excreted with feces - 70% and with urine - 30%, mostly unchanged. With biliary cirrhosis or obstruction of the bile ducts, the vascartan AUC increases approximately 2-fold.

Indications

• treatment of hypertension;
• treatment of chronic heart failure (NYHA class 2-4 functional class) in patients,receiving traditional therapy with diuretics, digitalis preparations, as well as with ACE inhibitors or beta-blockers.

Forms of release

Tablets coated with 40 mg, 80 mg, 160 mg.

Capsules 20 mg, 40 mg, 80 mg, 160 mg.

Instructions for use and dosage

Take inside at a dose of 80 mg 1 time per day or 40 mg 2 times a day, daily. If there is no adequate effect, the daily dose can be gradually increased.

The maximum daily dose is 320 mg in 2 divided doses.

Side effect

• arterial hypotension;
• postural dizziness;
• postural hypotension;
• dizziness;
• headache;
• diarrhea;
• nausea;
• increased bilirubin levels;
• impaired renal function;
• increased levels of creatinine and urea nitrogen (especially in chronic heart failure);
• hyperkalemia;
• neutropenia, a decrease in hemoglobin and hematocrit;
• angioedema;
• rash;
• itching;
• serum sickness;
• vasculitis;
• fatigue;
• general weakness;
• cough;
• pharyngitis;
• increased risk of developing viral infections.

Contraindications

• pregnancy;
• increased sensitivity to valsartan.

Application in pregnancy and lactation

Valsartan is contraindicated in pregnancy.

It is not known whether valsartan is excreted in human milk. Use during lactation (breastfeeding) is not recommended.

In experimental studies, it has been shown that valsartan is excreted in breast milk in rats.

Use in children

The safety and effectiveness of valsartan in children is not established, so it is contraindicated in children and adolescents under the age of 18 years.

special instructions

In cases of hyponatremia and / or a decrease in bcc, as well as against the background of therapy with high doses of diuretics, in rare cases valsartan can cause severe arterial hypotension. Before the start of treatment should be done correction of water-salt metabolism.

In patients with renovascular hypertension, which developed again due to stenosis of the renal artery, the level of urea and creatinine in the serum should be regularly monitored during the treatment period. Data on safety of use in patients with SC less than 10 ml / min are absent.

With extreme caution apply in patients with violations of patency of the biliary tract.

Due to the inhibition of RAAS in susceptible patients, changes in renal function are possible.With the use of ACE inhibitors and angiotensin receptor antagonists, oliguria and / or augmentation of azotemia were observed in patients with chronic heart failure of severe course, and acute renal failure with a risk of death was rare.

Impact on the ability to drive vehicles and manage mechanisms

When using valsartan, it is advisable to use caution when driving and controlling machinery.

Drug Interactions

With the simultaneous use of diuretics in high doses, it is possible to develop arterial hypotension.

With the simultaneous use of potassium-sparing diuretics, heparin, biologically active additives or substitutes for salt containing potassium, the development of hyperkalemia is possible.

With simultaneous use with indomethacin, a decrease in the antihypertensive effect of valsartan is possible.

At simultaneous application with lithium carbonate the case of development of lithium intoxication is described.

Analogues of the drug Valsartan

Structural analogs for the active substance:

• Artinova;
• Valaar;
• Wales;
• Wals H (with hydrochlorothiazide);
• Valsartan Zentiva;
• Valsafors;
• Walsakor;
• Valsakor H;
• Vanatex Combi;
• Diovan;
• Duopress;
• Ko Diovan;
• Nortivan;
• Tantordio;
• Tareg.

Similar medicines:

Other medicines: