Nalbuphin - instructions for use, reviews, analogs and forms of release (injections in ampoules for injections Serb 10 mg and 20 mg) of an anesthetic drug for the treatment and relief of pain in oncology in adults, children and in pregnancy

In this article, you can read the instructions for the use of an anesthetic drug Nalbuphine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nalbuphin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nalbuphin in the presence of existing structural analogues.Use to treat and arrest pain in oncology, myocardial infarction in adults, children, as well as during pregnancy and lactation.

Nalbuphine - an opioid analgesic, an opioid receptor antagonist agonist. Activates the endogenous antinociceptive system mainly through opioid kappa receptors and thus disrupts the interneuronal transmission of pain impulses at various levels of the central nervous system, and also changes the emotional color of the pain, affecting the higher parts of the brain.

Has a comparable morphine analgesic effect, has a sedative effect, stimulates the vomiting center, causes miosis, inhibits conditioned reflexes. To a lesser extent than the agonists of opioid mu receptors (morphine, promedol, fentanyl) depresses the respiratory center. Has no significant effect on hemodynamics and on the motility of the gastrointestinal tract.

The analgesic effect develops rapidly: with intravenous administration, after a few minutes; when intramuscular - after 10-15 minutes. The maximum effect is achieved in 1-2 hours, the duration of action is 3-6 hours.

Composition

Nalbuphine + excipients.

Pharmacokinetics

Metabolised in the liver.Unchanged nalbuphine is excreted mainly with urine (about 70%), in the form of metabolites - mainly with bile.

Indications

• severe pain syndrome of various genesis (including in the postoperative period, with myocardial infarction, with gynecological interventions, with malignant neoplasms);
• premedication before inhalation anesthesia;
• as a component of intravenous anesthesia.

Forms of release

Solution for intravenous and intramuscular injection (injections in ampoules for injection) Serb 10 mg and 20 mg.

There are no other dosage forms, be it pills or capsules.

Instructions for use and dosing regimen

Individual. Enter intravenously, intramuscularly and subcutaneously. For adults, the single dose varies from 100 μg / kg to 1 mg / kg. For children, the initial single dose is 300 μg / kg. The frequency of administration depends on the indications and the clinical situation. Duration of application - no more than 3 days.

Side effect

• drowsiness;
• retardation;
• dizziness;
• imbalance;
• headache;
• nervousness;
• depression;
• confusion of consciousness;
• dysphoria;
• difficulty in speaking;
• blurred vision;
• nausea, vomiting;
• dry mouth;
• arterial hypertension or hypotension;
• bradycardia, tachycardia;
• hives;
• increased sweating.

Contraindications

• hypersensitivity to nalbuphine.

Application in pregnancy and lactation

Use during pregnancy is possible only on strict indications.

Use with caution in premature birth and presumed immaturity of the fetus (because nalbuphine penetrates the placental barrier and can cause respiratory depression in the newborn).

Use with caution during lactation (breastfeeding).

Nalbuphine is excreted in mother's milk in very small, clinically insignificant amounts (less than 1% of the administered dose).

Application in elderly patients

With caution should be used in the elderly.

special instructions

With caution should be used for violations of respiratory function (including with obstructive pulmonary disease, emphysema), because Nalbuphine may cause a reduction in the minute volume of respiration by approximately 20-25% (when administered at a dose of 20 mg per 70 kg of body weight), with uremia, in the elderly, with severe depletion.

With caution and under constant supervision, nalbuphine should be used for trauma to the skull (due to the possible development of respiratory depression), increased intracranial pressure and pressure of CSF in the spinal canal.

In renal and hepatic insufficiency, nalbuphine should be thoroughly dosed and provided for the possibility of rapid cessation of administration.

Nalbuphine should not be combined with other opioid analgesics because of the risk of weakening analgesia and the possibility of provoking a withdrawal syndrome in patients with opioid dependence.

Under careful supervision and in reduced doses, nalbuphine should be used against the background of anesthetic agents, hypnotics, anxiolytics, antidepressants and antipsychotics (antipsychotics) in order to avoid excessive CNS suppression and inhibition of respiratory center activity.

Nalbuphine refers to narcotic opioid analgesics and a strict group of records because of the development of habituation with regular use.

Impact on the ability to drive vehicles and manage mechanisms

They are used with caution in outpatient settings in patients who engage in potentially hazardous activities,requiring increased attention and high speed of psychomotor reactions.

Drug Interactions

With simultaneous use with narcosis drugs, hypnotics, sedatives, anxiolytics (tranquilizers), antipsychotic drugs (antipsychotics), antidepressants, antihistamines with sedative effect, ethanol (alcohol), the oppressive effect on the central nervous system increases.

Analogues of the drug Nalbufin

Structural analogs for the active substance:

• Nalbuphine Serb;
• Nalbuphine hydrochloride.

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