Dipyridamole - instructions for use, reviews, analogs and formulations (tablets 25 mg, 50 mg and 75 mg, suspension) drugs for the treatment of thrombosis, embolism and circulatory disorders in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Dipyridamole. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Dipyridamole in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of dipyridamole in the presence of existing structural analogues. Use for the treatment of thrombosis, embolism and circulatory disorders in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Dipyridamole - antiaggregant, angioprotector, immunomodulator. Has a retarding effect on the aggregation of platelets, improves microcirculation.

Has vasodilator effect, reduces the resistance of resistive coronary vessels (mainly arterioles), increases the volume rate of coronary blood flow. Is able to reduce the perfusion of ischemic zones of the myocardium.

The mechanism of action is not finally clarified. It is believed that dipyridamole increases the adenosine content (disrupting its reuptake), and also promotes an increase in the concentration of cAMP due to inhibition of the enzyme PDE.

As a pyrimidine derivative, dipyridamole is an inducer of Interferon and has a modulating effect on the functional activity of the interferon system, increases the decreased production of interferon alfa and interferon gamma by leukocytes of blood. Increases nonspecific resistance to viral infections.

Composition

Dipyridamole + auxiliary substances.

Pharmacokinetics

After oral administration, dipyridamole is completely absorbed from the digestive tract. The binding with plasma proteins is high. Metabolized in the liver and excreted with bile mainly in the form of glucuronides.Excretion can be slowed down by enterohepatic recirculation. In a small amount is excreted in the urine.

Indications

• treatment and prevention of cerebral circulation disorders by ischemic type;
• encephalopathy;
• prevention of arterial and venous thrombosis and their complications;
• prevention of thromboembolism after surgery for prosthetic heart valves;
• prevention of placental insufficiency in a complicated pregnancy;
• disorders of microcirculation of any type (as part of complex therapy);
• prevention and treatment of influenza, ARVI (as an inducer of interferon and immunomodulator).

Forms of release

Tablets coated with 25 mg, 50 mg and 75 mg.

Suspension for oral administration 50 mg.

There are no other medicinal forms, be it capsules or injections in ampoules.

Instructions for use and dosing regimen

Pills

Inside, on an empty stomach, 1 hour before a meal, washing down a glass of water (you can milk).

For prophylaxis and therapy of thromboembolic complications - 75 mg 5-6 times a day, in combination with Acetylsalicylic acid - 3 times a day; with chronic coronary insufficiency - 75-100 mg 3 times a day.

Suspension

Inside.Shake before use!

Take for 1 h before meals. Dosage regimen is set by the doctor individually depending on the severity of the disease and the patient's response to treatment.

If the doctor is not assigned otherwise, the following dosing regimens are recommended: To reduce aggregation of platelets, it is recommended to use dipyridamole 300 mg / day in several doses (2 teaspoonfuls (100 mg) of a spoon 3 times a day). In severe cases, the dose may be increased to 600 mg per day.

For the prevention of influenza and other acute respiratory infections, especially during epidemics, take dipyridamole according to the following scheme: 50 mg (1 teaspoon) per day 1 time per 7 days for 4-5 weeks.

Side effect

• nausea, vomiting;
• diarrhea;
• arterial hypotension;
• tides;
• tachycardia (especially with simultaneous reception of vasodilators);
• dizziness;
• headache;
• skin rash;
• hives;
• myalgia;
• increased bleeding during or after surgery.

Contraindications

• acute myocardial infarction;
• widespread stenosing coronary atherosclerosis;
• unstable angina;
• subaortic stenosis of the aorta;
• Decompensated heart failure;
• severe arterial hypotension;
• severe heart rhythm disturbances;
• tendency to bleeding;
• severe renal failure;
• children's age till 12 years;
• hypersensitivity to dipyridamole.

Application in pregnancy and lactation

The use of dipyridamole during pregnancy, especially in the 2nd and 3rd trimesters, is possible in cases of extreme necessity.

Use in children

Contraindicated in children under 12 years of age (safety and efficacy not determined).

special instructions

Use with caution in patients with arterial hypotension, recent myocardial infarction, heart failure.

There is evidence that intravenous dipyridamole may cause uneven redistribution of blood flow in the coronary vessels and development of the steal syndrome, accompanied by aggravation of symptoms of angina (including depression of the ST segment on the ECG). In this regard, is not recommended iv introduction of dipyridamole.

Drug Interactions

With the simultaneous use of funds that reduce the acidity of the contents of the stomach (antacids, histamine H2-receptor blockers (incl.cimetidine), proton pump inhibitors (including omeprazole), the bioavailability of dipyridamole may decrease.

When used simultaneously with anticoagulants, acetylsalicylic acid, the antiplatelet effect of dipyridamole is enhanced.

With simultaneous use with anticholinergic drugs, memory and attention disorders in elderly patients are possible.

With simultaneous use with beta-blockers, cases of bradycardia and asystole are described with dipyridamole in patients receiving beta-blockers.

With simultaneous use with adenosine, the effect of adenosine is enhanced.

When used simultaneously with dobutamine, there is a risk of developing severe arterial hypotension.

When used simultaneously with caffeine, other xanthine derivatives, the effectiveness of dipyridamole decreases.

For the prevention of relapse, in patients who are often ill with respiratory viral infections, dipyridamole is recommended to be taken as follows: 100 mg (2 teaspoons) 2 times a day once a week for 8-10 weeks.

Analogues of the drug Dipyridamole

Structural analogs for the active substance:

• Courantil;
• Parsedil;
• Persantin;
• Sanomil Sanovel.

Similar medicines:

Other medicines: