Derinat - instructions for use, analogs, reviews and release forms (drops in the nose 0.25%, injections in ampoules for injection) of a medicament for the treatment of influenza, ARVI and other infectious diseases in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Derinath. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Derinata in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Derinata in the presence of existing structural analogs. Use to treat influenza, ARVI and other inflammatory and infectious diseases in adults, children,as well as during pregnancy and lactation.
Derinath - immunomodulator, which affects cellular and humoral immunity. Derinat stimulates reparative processes, has an anti-inflammatory effect, normalizes the tissue state in dystrophic changes in vascular genesis.
The drug activates antiviral, antifungal and antimicrobial immunity, has a high reparative and regenerative effect.
With external application, Derinat helps to heal trophic ulcers, infected wounds and deep burns, greatly accelerating epithelization. Under the action of Derinata, there is an incomplete scar healing of ulcerative defects on the mucous membrane.
Pharmacokinetics
Deoxyribonucleate sodium (active ingredient Derinat) is rapidly absorbed when applied topically and spreads through the lymphatic tract to organs and tissues. Sodium deoxyribonucleate is metabolized in the body. It is excreted mostly by the kidneys and partly by the feces.
Indications
As a monotherapy:
- prevention and treatment of ARVI;
- ARI;
- inflammatory and dystrophic eye diseases;
- inflammatory diseases of the oral mucosa.
As part of complex therapy:
- chronic inflammatory diseases, fungal, bacterial and other infections of mucous membranes in gynecology;
- acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis / including frontal sinusitis,);
- obliterating diseases of the lower limbs;
- trophic ulcers;
- gangrene;
- infected and long-term non-healing wounds (including diabetes mellitus);
- burns;
- frostbite;
- post-radiation necrosis of the skin and mucous membranes;
- hemorrhoids.
Forms of release
Solution for external and topical application 0.25% (drops in the nose).
Solution for intramuscular injection 15 mg / ml.
Instructions for use and dosing regimen
Derinat in the form of a solution for external and topical administration is prescribed depending on the localization of the pathological process.
The drug is prescribed to children from the first day of life and adults.
For the prevention of acute respiratory viral infusion, 2 drops are administered in each nasal passage 2-4 times a day for 1-2 weeks. When symptoms of respiratory disease appear, the drug is injected 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops per each nasal course 3-4 The course duration of therapy is from 5 days to 1 month .
With inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled by 3-5 drops in each nasal passage 4-6 times a day; the duration of the course is 7-15 days.
With inflammatory diseases of the oral cavity, rinse the oral cavity with a solution of the drug 4-6 times a day (1 bottle for 2-3 rinses). The duration of the course of therapy is 5-10 days.
With chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - intravaginal administration of tampons with the drug or irrigation of the vagina and cervix for 5 ml per procedure 1-2 times per day for 10-14 days.
With hemorrhoids, the drug is administered rectally with the help of a microclyster of 15-40 ml. The duration of treatment is 4-10 days.
In ophthalmic practice with severe inflammatory and dystrophic processes, Derinat is instilled in the eye 1-2 drops 2-3 times a day for 14-45 days.
With obliterating diseases of the lower extremities with the aim of achieving a systemic effect, the drug is instilled 1-2 drops into each nasal passage 6 times a day, the course duration is up to 6 months.
With post-ray necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns,frostbites, trophic ulcers of different etiology, gangrene on the affected areas are recommended to impose application dressings (gauze in 2 layers) with the application of the drug 3-4 times a day or carry out treatment of the affected surface with a drug from a nebulizer 10-40 ml 4-5 times a day. The course of treatment - 1-3 months.
Derinat is administered to adults intramuscularly (within 1-2 min) in an average single dose of 75 mg (5 ml solution for intramuscular administration of 15 mg / ml) with an injection interval of 24-72 hours.
Side effect
- in patients with diabetes mellitus, a hypoglycemic effect is noted, which should be taken into account by controlling the level of glucose in the blood;
- with external and local application of the drug, no side effects were identified.
Contraindications
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The patient should be warned that a doctor should be consulted before using the drug during pregnancy and during lactation. If you need to prescribe the drug during pregnancy, you should evaluate the expected benefit for the mother and the potential risk to the fetus.
special instructions
The drug does not have embryotoxic, teratogenic and carcinogenic effects.
Possible subcutaneous administration of the drug.
The drug potentiates the therapeutic effect of basic therapy for peptic ulcer of the stomach and duodenum.
Derinat reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with the achievement of 50% and 70% improvement in a number of complex indicators of disease activity.
With surgical sepsis, the introduction of Derinata into the composition of complex therapy causes a decrease in the level of intoxication, activation of immunity, normalization of hematopoiesis, improves the functioning of organs responsible for the processes of detoxification of the internal environment of the body (including lymph nodes, spleen).
According to recent clinical studies, the effectiveness of Derinata in patients with exacerbation of COPD of varying severity against standard therapy has been proven. Assign intramuscularly 5 ml of a solution of 15 mg / ml after 24-48 h, the course of treatment - 5-10 injections.
Drug Interactions
The use of Derinate in complex therapy allows to increase the efficiency and reduce the duration of therapy, with a significant reduction in the doses of antibiotics and antiviral agents with an increase in the periods of remission.
Derinat increases the effectiveness of antitumor antibiotics anthracycline, cytostatics.
Analogues of drug Derinath
Structural analogs for the active substance:
- Deoxynate;
- Sodium deoxyribonucleate;
- Panagen.
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