Norfloxacin - instructions for use, analogs, reviews and release forms (tablets 200 mg and 400 mg, eye drops and ear drops) of an antibiotic drug for the treatment of cystitis, gonorrhea, blepharitis, conjunctivitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Norfloxacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Norfloxacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Norfloxacin analogues in the presence of existing structural analogues.Use for the treatment of cystitis, gonorrhea, blepharitis, conjunctivitis in adults, children, as well as during pregnancy and lactation. Composition of antibiotic.

Norfloxacin - antimicrobial synthetic agent of a group of fluoroquinolones of a wide spectrum of action. Has a bactericidal effect. Suppressing the DNA-gyrase, violates the process of supercoiling of DNA.

Highly active against most Gram-negative bacteria: Escherichia coli (E. coli), Salmonella spp. (salmonella), Shigella spp. (Shigella), Proteus spp. (Proteus), Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

It is active against some gram-positive bacteria (including Staphylococcus aureus (staphylococcus)).

To norfloxacin resistant anaerobic bacteria are resistant, low-sensitivity Enterococcus spp. and Acinetobacter spp.

Resistant to the action of beta-lactamases.

Composition

Norfloxacin + excipients.

Pharmacokinetics

When ingested absorbed about 30-40%, eating reduces the absorption rate. Binding to plasma proteins is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates through the placental barrier. About 30% is excreted unchanged in urine.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to norfloxacin.

For oral administration:

• diseases of the urinary tract;
• prostate gland;
• GIT;
• gonorrhea;
• prevention of recurrence of urinary tract infections;
• bacterial infections in patients with granulocytopenia;
• "traveler's diarrhea".

For topical application:

• conjunctivitis;
• keratitis;
• keratoconjunctivitis;
• corneal ulcers;
• blepharitis;
• blepharoconjunctivitis;
• acute inflammation of the meibomian glands and dacryocystitis;
• prevention of eye infections after removal of a foreign body from the cornea or conjunctiva, after damage by chemical agents, before and after surgical interventions on the eyes;
• otitis externa;
• acute otitis media;
• chronic otitis media;
• prevention of infectious complications in surgical interventions on the hearing organ.

Forms of release

Tablets coated with 200 mg and 400 mg (sometimes mistakenly called capsules).

Eye drops.

Ear drops.

Instructions for use and dosing regimen

Individual. Single dose for oral administration is 400-800 mg, the frequency of application - 1-2 times a day. The duration of treatment is determined individually.

In ophthalmology and ENT-practice apply topically in the form of drops.

Side effect

• nausea;
• heartburn;
• anorexia;
• diarrhea;
• stomach ache;
• headache;
• dizziness;
• feeling tired;
• sleep disorders;
• irritability;
• sense of anxiety;
• skin rash;
• itching;
• angioedema;
• interstitial nephritis.

Contraindications

• pregnancy;
• lactation (breastfeeding);
• children and adolescence (up to 15 years);
• deficiency of glucose-6-phosphate dehydrogenase;
• increased sensitivity to norfloxacin and other preparations of the quinolone series.

Application in pregnancy and lactation

Norfloxacin is contraindicated in pregnancy and lactation (breastfeeding), because in experimental studies it is established that it causes arthropathy.

Use in children

Contraindicated in childhood and adolescence (up to 15 years).

special instructions

It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe impairment of kidney and liver function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken at least 2 hours before or 2 hours after ingestion of antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate.

Drug Interactions

With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporine, there is an increase in the concentration of the latter in the blood plasma.

When simultaneous administration of norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate, norfloxacin absorption decreases due to formation of chelating with metal ions (the interval between their intake should be at least 4 hours).

With the simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, so with simultaneous use should reduce the dose of theophylline.

Simultaneous administration of norfloxacin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, it is necessary to monitor heart rate, blood pressure, ECG parameters.Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.

Analogues of Norfloxacin

Structural analogs for the active substance:

• Loxon 400;
• Nolycin;
• Norbaktin;
• Norillet;
• Normax;
• Noroksin;
• Norfacin;
• Norfloxacin Lugal;
• Renor;
• Sofazine;
• Chibroxin;
• Utibid.

Analogues for the pharmacological group (quinolones and fluoroquinolones):

• Abaktal;
• Avelox;
• Altsipro;
• Vigamox;
• Glevo;
• Zanotsin;
• Zofloks;
• Quipro;
• Levot P;
• Levofloxacin;
• Lomefloxacin;
• Moxifloxacin;
• Nevigramon;
• The Negroes;
• Norillet;
• Ofloks;
• Ofloxacin;
• Ofloxin;
• Pefloxabol;
• Pipem;
• Plevilox;
• Recipro;
• Siflox;
• Tavanik;
• Uniflox;
• Factual;
• Flexine;
• Floxal;
• Floracid;
• Hayleflex;
• Ciprinol;
• Ciprobay;
• Tsiprolet;
• Ciprosan;
• Ciprofloxacin;
• Tsifran;
• Eleflox;
• Utibid.

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