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Neurobion - instructions for use, analogs, reviews and release forms (tablets, injections in ampoules for injections in solution) drugs for the treatment of lumbago, neuralgia and paresis in adults, children and pregnancy. Composition

Neurobion - instructions for use, analogs, reviews and release forms (tablets, injections in ampoules for injections in solution) drugs for the treatment of lumbago, neuralgia and paresis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Neurobion. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of doctors specialists on the use of Neurobion in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neurobion in the presence of existing structural analogues. Use to treat lumbago, neuralgia and paresis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Neurobion - a complex of B vitamins.The Vitamins - thiamin (B1), pyridoxine (B6) and cyanocobalamin (B12), which are present in the preparation, play a special role as coenzymes in the intermediate metabolism taking place in the central and peripheral nervous system.

 

A special role in the metabolic processes of the nervous system is played by the combined action of vitamins B1, B6 and B12, which justifies their joint application. The combined use of B vitamins accelerates the regeneration of damaged nerve fibers. It is proved that the efficiency of the combination is superior to that of a single component. Like other vitamins, they are essential nutrients that can not be synthesized directly in the body.

 

The therapeutic use of these vitamins in various diseases of the nervous system is aimed at compensating, on the one hand, the existing insufficiency (possibly because of the increased body requirement due to the disease itself) and, on the other hand, to stimulate the natural mechanisms of restoring the function of nerve tissues. Also, the analgesic effect of the vitamin B complex of vitamins has been shown to have a beneficial effect on the therapeutic outcome.

 

Composition

 

Thiamine hydrochloride (vitamin B1) + Pyridoxine hydrochloride (vitamin B6) + Cyanocobalamin (vitamin B12) + excipients.

 

Pharmacokinetics

 

Thiamine

 

After ingestion, thiamine is exposed to a dose-dependent transport, the mechanism of which is of a dual nature: active absorption at a concentration of up to 2 μmol / l and passive diffusion at concentrations above 2 μmol / L. In the liver, thiamine is phosphorylated. In the human body contains about 30 mg of thiamine. Given the rapid metabolism, it is excreted after 4-10 days.

 

Pyridoxine

 

Pyridoxine is absorbed very rapidly, mainly in the upper intestine and is excreted after a maximum of 2-5 hours. The performance of the coenzyme function requires the phosphorylation of pyridoxine. Pyridoxine in phosphorylated form (pyridoxalphosphate) almost 80% binds to blood plasma proteins. In the human body contains about 40-150 mg. In a day with urine, 1.7-3.6 mg is excreted.

 

Cyanocobalamin

 

Cyanocobalamin is absorbed from the digestive tract through 2 mechanisms: 1) release under the action of gastric juice and rapid binding to the internal factor; 2) passive diffusion through the intestinal epithelium irrespective of the internal factor.At doses greater than 1.5 μg, the latter mechanism plays a significant role. In patients with B12-deficient anemia, reabsorption after ingestion is approximately 1% of 100 μg or more. Excess vitamin B12 accumulates in the liver. From the liver it is excreted with bile into the intestine and is largely reabsorbed in the intestinal-hepatic circulation. The metabolic rate of vitamin B12 per day is 2.5 μg.

 

Indications

 

In the complex therapy of diseases of the nervous system of various origins:

  • neuralgia of the trigeminal nerve;
  • paresis of the facial nerve;
  • pain syndrome caused by diseases of the spine (intercostal neuralgia, lumbar syndrome, cervical syndrome, shoulder-brush syndrome, radicular syndrome caused by degenerative changes of the spine);
  • lumbago, sciatica;
  • herpes zoster (shingles).

 

Forms of release

 

Solution for intramuscular injection (injections in ampoules for injection).

 

The tablets covered with a cover.

 

Instructions for use and dosing regimen

 

Ampoules

 

The drug is injected intramuscularly (deep injections into the gluteus muscle).

 

In cases of severe pain, it is advisable to start treatment with intramuscular injection of 3 ml (1 ampoule) a day before the acute symptoms are removed.

 

After reducing the symptoms or in case of moderate pain, the drug is administered 3 ml (1 ampoule) 2-3 times a week for 2-3 weeks.

 

For maintenance therapy, for the prevention of recurrence or continuation of the current course of treatment, it is recommended to take the drug Neurobion orally in the form of tablets.

 

Pills

 

Tablets are taken orally, without chewing, with a small amount of water, during or after a meal.

 

The drug should be taken 1 tablet 3 times a day or as directed by a doctor.

 

The duration of treatment is determined by the doctor and on average is 1-1.5 months.

 

It is recommended to correct the dose of the drug for more than 4 weeks.

 

Side effect

  • sweating;
  • tachycardia;
  • allergic reactions in the form of skin itching and rash;
  • hypersensitivity reactions: exanthema, shortness of breath, anaphylactic shock (after parenteral administration of vitamin B1);
  • acne;
  • eczema;
  • hives;
  • nausea, vomiting;
  • diarrhea;
  • stomach ache.

 

Contraindications

  • children's age (up to 18 years);
  • hypersensitivity to any component of the drug.

 

Application in pregnancy and lactation

 

It is not recommended to use Neurobion during pregnancy and lactation.

 

Use in children

 

Contraindicated in children and adolescents under the age of 18 (due to the high content of active substances).

 

special instructions

 

The drug should not be administered intravenously.

 

Other vitamins, especially cyanocobalamin, can be inactivated in the presence of vitamin B1 degradation products.

 

The clinical picture, as well as laboratory tests with funicular myelosis or pernicious anemia, may lose their specificity when introducing vitamin B12.

 

Overdose

 

After the introduction of vitamin B1 in a dose exceeding the recommended more than 100 times, headache, muscle spasm, muscle weakness, paralysis, arrhythmia, allergic reactions were observed.

 

After the introduction of vitamin B6 in high doses, neuropathies with ataxia, sensitivity disorders, epileptiform seizures with changes in the EEG were observed. After administration of a dose of more than 2 g / day, cases of hypochromic anemia and seborrheic dermatitis have been described.

 

After parenteral administration of vitamin B12 in a high dose, allergic reactions, eczematous skin disorders and a benign form of acne were observed.

 

Treatment:

  • abolish drug intake;
  • if necessary, symptomatic therapy is prescribed, incl. desensitizing.

 

Drug Interactions

 

With simultaneous application with levodopa, vitamin B6 can reduce the antiparkinsonian action of levodopa.

 

Increased demand for vitamin B6 may occur with the simultaneous administration of D-penicylamine and cycloserine.

 

It is not recommended to mix the drug with other drugs in one syringe.

 

Vitamin B1 is destroyed by interaction with solutions containing sulfites.

 

Analogues of the drug Neurobion

 

Structural analogs for the active substance:

  • Milgamma;
  • Milgamma compositum;
  • Neurotrate forte;
  • Polinevrin;
  • Unigamma.

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