Berlition 300 and 600 - instructions for use, reviews, analogs and forms of release (tablets or capsules 300 mg, injections in injections) of the hepatoprotector drug for the treatment of hepatitis, cirrhosis in adults, children and pregnancy
In this article, you can read the instructions for using the drug Berlition 300 and 600. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of hepatoprotector Berlition 300 and 600 in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Berlition 300 and 600 in the presence of existing structural analogs.Use for the treatment of hepatitis, cirrhosis, alcoholic and diabetic polyneuropathy in adults, children, as well as during pregnancy and lactation.
Berlition 300 and 600 - endogenous antioxidant (binds free radicals), is formed in the body by oxidative decarboxylation of alpha-keto acids. As a coenzyme mitochondrial multienzyme complexes is involved in the oxidative carboxylation of pyruvic acid and alpha-keto acids.
Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of the biochemical action is close to the Vitamins of group B. It participates in the regulation of lipid and carbohydrate metabolism, stimulates the exchange of cholesterol, improves liver function.
Has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic action.
Composition
Thioktovaya (Alpha lipoic acid) + auxiliary substances.
Pharmacokinetics
After ingestion, Berlition quickly and completely absorbed from the digestive tract. Admission with food reduces absorption. Bioavailability is 30%. Has the effect of "first pass" through the liver.The formation of metabolites occurs as a result of oxidation of the side chain and conjugation. Thioctic acid and its metabolites are excreted in the urine (80-90%).
Indications
- chronic hepatitis;
- fibrosis and cirrhosis of the liver;
- fatty degeneration of the liver;
- toxic effects of metals;
- diabetic polyneuropathy;
- alcoholic polyneuropathy.
Forms of release
The tablets covered with a cover of 300 mg (sometimes wrongly called capsules).
Concentrate for the preparation of a solution for infusion (Berlition 300) (injections in ampoules for injections).
Concentrate for the preparation of solution for infusion (Berlition 600).
Instructions for use and dosing regimen
Pills
Inside appoint 600 mg (2 tablets) once a day. Tablets are taken on an empty stomach, approximately 30 minutes before the first meal, without chewing and washing down with a sufficient amount of liquid. The duration of the course of treatment is determined by the doctor individually.
Ampoules
Intravenous (jet slowly or drip in the form of a dropper) is administered 300-600 mg per day.
Side effect
- dyspepsia;
- nausea, vomiting;
- heartburn;
- hypoglycemia (due to improved glucose uptake);
- convulsions;
- thrombocytopathy;
- hemorrhagic rash (purpura);
- thrombophlebitis;
- allergic reactions;
- rash;
- itching;
- hives.
Contraindications
- children's age (effectiveness and safety not established);
- pregnancy (there is insufficient experience of the drug);
- breastfeeding (there is insufficient experience in using the drug);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The use of the drug Berlition during pregnancy and during lactation is contraindicated because of the lack of sufficient clinical data to confirm the safety and efficacy of the drug in this category of patients.
Use in children
Contraindicated in children and adolescents under the age of 18 years.
special instructions
The drug solution should be protected from exposure to light, for example, using aluminum foil. The light-shielded solution can be stored for approximately 6 hours. Patients with diabetes require constant monitoring of blood glucose concentration, especially at the initial stage of therapy. In some cases, it is necessary to reduce the dose of insulin or an oral hypoglycemic drug in order to avoid the development of hypoglycemia.
Patients taking the drug Berlition should refrain from drinking alcohol.
Drug Interactions
Thioktovaya (alpha lipoic) acid interacts with ionic metal complexes (for example, with cisplatin). Therefore, with simultaneous admission, it is possible to reduce the effect of cisplatin.
After taking the drug in the morning, apply iron, magnesium, and dairy products (because of the calcium content in them) is recommended after lunch or in the evening.
With the simultaneous use of ethanol (alcohol) and its metabolites can reduce the therapeutic activity of thioctic (alpha lipoic) acid.
With the simultaneous use of Berlition enhances the hypoglycemic action of insulin and oral hypoglycemic agents.
Analogues of the drug Berlition 300 and 600
Structural analogs for the active substance:
- Alpha lipoic acid;
- Lipamid;
- Lipoic acid;
- Liptiokson;
- Neurolephone;
- Octolipen;
- Tiogamma;
- Thiocacid 600;
- Thioctic acid;
- Thiolept;
- Thiolipone;
- Espa Lipon.
Analogues for the pharmacological group (hepatoprotectors):
- Antraliv;
- Berlition 300;
- Berlition 600;
- Bondjigar;
- Brentzialle forte;
- Vitanorm;
- Gepa Merz;
- Gepabene;
- Heptral;
- Covechol;
- Karsil;
- Legalon;
- Liv.52;
- Livedoksa;
- Methionine;
- Metrop;
- Ornitsetil;
- Progepar;
- Milk thistle;
- Resalute Pro;
- Sibektan;
- Silegon;
- Silibinin;
- Sylimar;
- Silymarin;
- Sirepard;
- Thioctic acid;
- Thiolipone;
- Tiotriazolin;
- Tyqveol;
- Urdoks;
- Urso 100;
- Ursodez;
- Ursodeoxycholic acid;
- Ursodex;
- Ursuliv;
- Ursoron Rompharm;
- Ursosan;
- Ursofalk;
- Phosphogliv;
- Phosphontsiale;
- Hepabos;
- Holudexan;
- Erbisol;
- Eslidine;
- Essentiale N;
- Essentiale forte N;
- Essential phospholipids;
- The Essler.
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