Lipoic acid - instructions for use, reviews, analogs and formulations (tablets 12 mg and 25 mg, injections in ampoules for injection 3%) drugs for the treatment of diabetic polyneuropathy and weight loss in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Lipoic acid. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Lipoic acid in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of lipoic acid in the presence of existing structural analogues.Use for the treatment of diabetic polyneuropathy and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Lipoic acid - is an endogenous antioxidant that binds free radicals. Thioktovaya (alpha-lipoic) acid (the active substance of the drug Lipoic acid) is involved in the mitochondrial metabolism of cells, it performs the function of coenzyme in the complex of transformation of substances with a pronounced antitoxic effect. They protect the cell from reactive radicals arising from intermediate metabolism or from the decay of exogenous foreign substances and from heavy metals. Thioctic acid shows a synergism with respect to insulin, which is associated with an increase in the utilization of glucose. In patients with diabetes, thioctic acid leads to a change in the concentration of pyruvic acid in the blood.

Composition

Thioctic acid + auxiliary substances.

Indications

• diabetic polyneuropathy;
• alcoholic polyneuropathy;
• fatty degeneration of the liver;
• cirrhosis of the liver;
• chronic hepatitis;
• hepatitis A;
• intoxication (including salts of heavy metals);
• poisoning with pale toadstool;
• hyperlipidemia (incl.with the development of coronary atherosclerosis - treatment and prevention).

Forms of release

Tablets coated with 12 mg, 25 mg, 200 mg, 300 mg and 600 mg.

Injections in ampoules for injection (3% solution).

Instructions for use and dosage

Intravenous lipoic acid is administered 300-600 mg per day, and this is 1-2 ampoules of 10 ml + 1 ampoule per 20 ml of a 3% solution. The duration of treatment is 2-4 weeks. After that continue supporting therapy in the form of taking tablets. The daily dose of maintenance therapy is 300-600 mg per day.

For the treatment of liver diseases and intoxication, tablets of 25 mg or 12 mg are used. They are swallowed. For adults, the dose is 50 mg up to 4 times a day. Children over 6 years can drink them up to 3 times a day. And so on until a month. If necessary, the course of treatment is repeated after 1 month.

For the treatment of alcohol and diabetic neuropathy, tablets of 200, 300 and 600 mg are used. They are swallowed whole on an empty stomach, washed down with water. half an hour before breakfast, up to 600 mg per day. Treatment begins with parenteral administration.

Side effect

• diplopia;
• convulsions;
• point hemorrhages in the mucous membranes and skin;
• impaired platelet function;
• with rapid administration - increased intracranial pressure;
• dyspeptic phenomena (including nausea, vomiting, heartburn);
• allergic reactions (hives, anaphylactic shock);
• hypoglycemia.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• Children under 6 years old (under 18 years old in the treatment of diabetic and alcoholic polyneuropathy);
• hypersensitivity to thioctic acid.

Application in pregnancy and lactation

Lipoic acid is contraindicated in pregnancy and lactation.

Use in children

Contraindicated in children under the age of 6 (up to 18 years in the treatment of diabetic and alcoholic polyneuropathy).

special instructions

During the period of treatment, regular monitoring of blood glucose concentration (especially at the beginning of therapy) is necessary in patients with diabetes mellitus.

Patients are advised to refrain from taking alcoholic beverages during treatment.

There is an opinion on the possibility of using the drug Lipoic acid for weight loss, but there is no clinical data on the use of the drug to reduce excess weight.

Drug Interactions

With simultaneous use, it is possible to increase the hypoglycemic action of insulin and oral hypoglycemic agents.

When used simultaneously with cisplatin, its effectiveness may be reduced.

Thioctic acid (in the form of a solution for infusions) is incompatible with a solution of Dextrose and Ringer's solution.

Analogues of the drug Lipoic acid

Structural analogs for the active substance:

• Alpha lipoic acid;
• Berlition;
• Lipamid tablets;
• Liptiokson;
• Neurolephone;
• Octolipen;
• Tiogamma;
• Tioctacid;
• Thioctic acid;
• Thiolept;
• Thiolipone;
• Espa Lipon.

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