Mirolyut - instructions for use, analogs, reviews and release form (tablets of 200 mcg) of the drug to induce abortion or medical abortion in women. Composition and duration of action

In this article, you can read the instructions for using the drug Mirolyut. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Mirolyut in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mirolyut in the presence of existing structural analogs. Use for abortion or medical abortion in women. Composition and interval of action or intake of the drug.

Mirolyut - a synthetic derivative of prostaglandin E1. It induces contraction of smooth muscle fibers of myometrium and expansion of the cervix. The ability of Misoprostol (the active ingredient of the drug Mirolut) to stimulate uterine contractions facilitates the opening of the cervix and the removal of the contents of the uterine cavity.

The drug has a weak stimulating effect on the smooth muscles of the gastrointestinal tract. Misoprostol in high doses inhibits the secretion of gastric juice.

Miroljut has no clinically significant effect on the level of prolactin, gonadotropins, TSH, STH, T4, cortisol, creatinine, platelet aggregation, lung function, and the state of the cardiovascular system.

Composition

Misoprostol + excipients.

Pharmacokinetics

When administered orally, it is quickly absorbed. Simultaneous reception with food reduces the bioavailability of misoprostol (fatty foods significantly reduce absorption without affecting the duration of absorption). Do not cumulate. Metabolised in the gastrointestinal tract and liver to the pharmacologically active diesterified metabolite - misoprostol acid. It is excreted mainly through the digestive tract and kidneys (less than 1%).

Indications

• interruption of pregnancy in early periods (up to 42 days amenorrhea) in combination with mifepristone (medical abortion).

Forms of release

Tablets 200 mcg.

Instructions for use and reception scheme

The drug should be used for abortion in combination with Mifepristone only in specialized institutions that have appropriately trained medical personnel who have the capacity to provide emergency surgical gynecological and blood transfusion care. The use of the drug requires the prevention of Rh-conflict and other common activities associated with abortion.

The drug is prescribed 400 μg (2 tablets) 36-48 hours after taking 600 mg (3 tablets) of mifepristone.

Side effect

• nausea, vomiting;
• flatulence;
• diarrhea;
• dizziness;
• headache;
• cramping pain in the lower abdomen.

Contraindications

• diseases of the cardiovascular system;
• liver and kidney disease;
• diseases associated with prostaglandin dependence, or contraindications to the use of prostaglandins (glaucoma, bronchial asthma, arterial hypertension);
• Endocrinopathy and endocrine system diseases (incl.diabetes mellitus, adrenal dysfunction);
• hormone-dependent tumors;
• anemia;
• lactation period (breastfeeding);
• use of intrauterine contraceptives (prior to use, remove IUD);
• suspicion of ectopic pregnancy;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug can be used in pregnant women only for abortion. It is necessary to inform patients about the potential danger of miroluta (teratogenic effect).

If it is necessary to use the drug during lactation, breastfeeding should be stopped for 7 days from the moment of taking mifepristone while performing medical abortion and for 5 days from the time of taking misoprostol.

special instructions

When used to interrupt pregnancy at an early age, Mirolut should be used only in combination with mifepristone. In combination with mifepristone misoprostol should be used only for the intended purpose and under the supervision of a doctor and only in specialized medical institutions that have the capacity to provide emergency surgical gynecological and blood transfusion care.The use of the drug requires the prevention of rhesus-conflict and other common activities conducted with abortion.

Before the appointment of misoprostol, the patient should be informed in detail about the effect and possible side effects of the drug. The patient should be observed in the conditions of the medical institution for 4-6 hours before taking the drug. During and after taking the drug, the patient should receive timely medical attention in the event of massive bleeding or other complications. After taking the drug in patients, as a rule, there is a slight vaginal bleeding, in some cases, prolonged. At very early gestation, abortion is possible after taking mifepristone, but in this case, it is also necessary to take misoprostol tablets to optimize the results of medical abortion. After taking misoprostol in about 80% of women, abortion occurs within 6 hours and about 10% of women within 1 week. Patients should be re-examined in the same treatment facility 8-15 days after the drug is administered. If necessary, an ultrasound or a level of chorionic gonadotropin in the blood serum should be performed.If there is a suspicion of incomplete abortion or pregnancy, it is necessary to conduct a comprehensive medical examination in a timely manner.

In case of incomplete abortion or continuing pregnancy, estimated on the 10-14th day after taking mifepristone, it is necessary to carry out vacuum-masking followed by a histological examination of the aspirate with an assessment of the effect of the drug on the formation of congenital malformations in the fetus.

Within 1 week after using misoprostol, you should stop taking Acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (NSAIDs).

It is released by prescription.

Drug Interactions

Long-term use of rifampicin, isoniazid, anticonvulsants, antidepressants, cimetidine, acetylsalicylic acid, Indomethacin and preparations of the Phenobarbital group, smoking more than 10 cigarettes a day stimulates the metabolism of misoprostol, reducing its concentration in the blood serum.

Analogues of the drug Mirolut

Structural analogs for the active substance:

• Misoprostol;
• Saitotec.

Analogues on the pharmacological group (medical abortion):

• Mifepristone;
• Pencrofton;
• Resonative;
• Enzaprost F.

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