Vestibo - instructions for use, analogs, reviews and release forms (tablets 8 mg, 16 mg and 24 mg) of the drug for the treatment of Meniere's disease, labyrinthitis and accompanying dizziness, tinnitus in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Vestiibo. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Vestibo in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Vestibo with existing structural analogues. Use to treat Meniere's disease, labyrinthitis and accompanying dizziness,noise in the ears of adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Vestiibo - a synthetic analog of histamine. It is a weak agonist of histamine H1 receptors and a rather potent antagonist of histamine H3 receptors. Has a histamine-like and vasodilating effect. Affects the cochlear blood flow and central vestibular apparatus.
The action of the drug includes vasodilation in the inner ear (indirectly through histamine H3 and H1 receptors), an inhibitory effect on the vestibular nuclei (via histamine H3 receptors), and impulsive activity of the ampullar receptors. By direct agonistic action on the histamine H1 receptors of the inner ear vessels and precapillary sphincters of the microcirculatory bed located in the vascular stria, as well as indirectly through histamine H3 receptors, improves the microcirculation and permeability of the inner ear capillaries, normalizes the endolymph pressure in the labyrinth and snail, increases blood flow in the basilar artery.
Has a pronounced central effect, being an antagonist of histamine H3 receptors in the nuclei of the vestibular nerve.Normalizes conductivity in polysynaptic neurons of vestibular nuclei at the level of the brainstem. Mediating indirectly on histamine H3 receptors, it increases the serotonin content in the brain stem, which reduces the activity of the vestibular nuclei.
Helps eliminate violations from both the vestibular and cochlear apparatus: reduces the frequency and intensity of dizziness, reduces tinnitus, helps improve hearing in cases of its decline.
Betagistin (the active substance of the drug Vestihibo) stimulates histamine H1 receptors, so it does not have a sedative effect and does not cause drowsiness.
Composition
Betahistine dihydrochloride + excipients.
Pharmacokinetics
After oral administration, Vestibo is rapidly absorbed from the digestive tract. Binding to plasma proteins is low. Virtually completely excreted in the urine in the form of a metabolite (2-pyridylacetic acid) for 24 hours.
Indications
- edema of the labyrinth of the inner ear;
- vestibular and labyrinthine disorders, incl. dizziness, noise and pain in the ears, headache, nausea, vomiting, hearing loss;
- vestibular neuritis;
- labyrinthite;
- benign positional dizziness (including after neurosurgical operations);
- Meniere's disease;
- vertebrobasilar insufficiency, posttraumatic encephalopathy, atherosclerosis of cerebral vessels (as part of complex therapy).
Forms of release
Tablets 8 mg, 16 mg and 24 mg.
Instructions for use and dosing regimen
The drug in tablets of 8 mg should be prescribed 1 tablet 3 times a day.
The drug in tablets of 16 mg should be prescribed 1 tablet 3 times a day.
The drug in tablets of 24 mg should be prescribed for 1 / 2-1 tablets 2 times a day.
The maximum daily dose is 48 mg. Treatment is long.
Tablets should be taken orally while eating, without chewing, squeezed with a small amount of liquid.
Side effect
- dyspepsia (nausea, vomiting);
- skin rash;
- angioedema.
Contraindications
- pheochromocytoma;
- bronchial asthma;
- peptic ulcer of the stomach and duodenum in the phase of exacerbation;
- 1 trimester of pregnancy;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The drug is contraindicated for use in the first trimester of pregnancy.
Use in children
Caution should be given to children.
special instructions
The therapeutic effect of the drug in a number of cases appears only a few months after the start of treatment.
With caution should prescribe the drug with peptic ulcer of the stomach or duodenum in the history, in the 2 and 3 trimesters of pregnancy, as well as children.
Drug Interactions
Antihistamines with simultaneous intake reduce the effect of Vestibo.
Analogues of the drug Vestibo
Structural analogs for the active substance:
- Asnithon;
- Betaver;
- Betagistin;
- Betaserc;
- Betacentrine;
- Vasoserk;
- Vestap;
- Denoise;
- The micrometer;
- Tagist.
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