Mikospor - instructions for use, reviews, analogues and forms of release (ointment Set for nails, cream and solution or spray 1% for external use) of a drug for the treatment of fungus, candidiasis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Mycospores. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mycospores in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Micospores in the presence of existing structural analogues.Use for the treatment of fungus nails, feet and other mycoses in adults, children, as well as during pregnancy and lactation.

Mycospores - has fungicidal action against dermatophytes (in particular, with respect to Trichophyton spp.). When yeast fungi, for example, Candida species are affected, at a concentration of 1-4 μg / ml, the predominantly fungistatic effect of bifonazole is noted (the active substance of the preparation Mikospor); for the fungicidal effect, a concentration of bifonazole of 20 μg / ml is required. Bifonazole also active against Corynebacterium minutissimum (MIC 0.5 to 2 mg / ml) Gram-positive cocci, with the exception of enterococci (MIC 4 to 16 ug / ml).

Resistant strains of fungi are very rare. Studies have not confirmed the development of secondary resistance in the primary sensitive strains.

Mycospore inhibits the biosynthesis of ergosterol at two different levels, which distinguishes it from other antifungal drugs and other azole derivatives. This double action leads to structural and functional damage to the cytoplasmic membrane of fungi.

Composition

Bifonazole + auxiliary substances (solution and cream).

Bifonazole + Urea + excipients (Ointment Mikospor Set).

Pharmacokinetics

Mycosorpus penetrates well into the affected layers of the skin. After 6 hours after application, concentrations in different layers of skin reach from 1000 μg / cm3 in the upper layer of the epidermis (in the stratum corneum) to 5 μg / cm3 in the papillary layer. Thus, all the concentrations obtained are within the range of antifungal activity. When applied to intact skin, an insignificant amount of bifonazole is absorbed (0.6-0.8% of the dose of the drug); the concentration level of bifonazole in the blood plasma is always below the detection limit (ie <1 ng / ml). Minor absorption is detected only after applying a solution of bifonazole on the inflamed skin (2-4% of the dose of the drug). Thus, since very low concentrations of bifonazole are created in the blood plasma at its place of application (usually no higher than 5 ng / ml), then no systemic effects are observed. The duration of stay in the skin (determined by the protective effect against fungal infection in guinea pigs) is 36-48 hours. Bifonazole penetrates the placental barrier in rats.

Indications

Fungal skin diseases caused by dermatophytes, yeast-like, mold fungi, as well as Malassezia furfur and Corynebacterium minutissimum:

mycosis stop (dermatophytosis of the skin of the foot and interdigital dermatophytosis of the feet);
mycosis of the hands (dermatophytosis of the skin of the hands and interdigital dermatophytosis);
dermatophytosis of smooth skin of the body;
dermatophytosis of the inguinal region;
superficial candidiasis of the skin;
onychomycosis (nail fungus)
pityriasis lichen;
erythrasma.

Forms of release

Solution for external use 1% (sometimes mistakenly called a spray).

Cream for external use 1%.

Ointment for external use (in a set for the treatment of nails) (Mycospores Set).

Instructions for use and how to use them

Ointment

Outwardly. In the absence of other prescriptions, the ointment is applied to the infected nail once a day in an amount sufficient to cover the entire surface of the nail with a thin layer. Then the processed nail is pasted with adhesive tape and left under the bandage for 24 hours, after which the bandage is changed. After removal of the patch, the treated surface is immersed in warm water for about 10 minutes and then gently removed with a scraper the softened part of the infected nail.Treated in this way, the nails are carefully dried, again applied to the ointment and sealed with a patch. Do not cover with ointment skin areas adjacent to the nail. In case of signs of irritation, the skin around the nail before applying the patch can be treated with zinc-containing paste.

Change bandages are produced every day. The treatment is continued until the softened nail plate infected with the fungus ceases to be removed by the scraper and the nail bed becomes smooth. This usually takes 7-14 days, depending on the extent of infection and the thickness of the nail.

The drug acts only on the infected nail plate, without affecting the healthy areas.

After removal of the affected nail plate, the attending physician should check whether the onycholysis is completed, if necessary, completely cleaning the nail bed and prescribing the final antifungal therapy. The final antifungal therapy of the nail bed should be performed with the help of the preparation Mycospores cream for external use once a day for 4 weeks.

Solution

Externally, the solution is applied a thin layer on the affected skin areas 1 time per day, preferably overnight,and gently rub.

To achieve a satisfactory result, treatment should be continuous.

The duration of therapy is usually:

with foot mycoses (dermatophytosis of the foot skin and interdigital dermatophytosis of the feet): 3 weeks,
with mycosis of the hands (dermatophytosis of the skin of the hands and interdigital dermatophytosis), skin of the body (smooth skin dermatophytosis) and skin folds (inguinal dermatophytosis): 2-3 weeks,
with pityriasis, ehratrazme: 2 weeks,
with superficial candidiasis of the skin: 2-4 weeks.

For the treatment of a surface approximately equal to the area of the palm, a few drops of the solution (about 3 drops) are sufficient.

Cream

Externally, the cream is applied a thin layer on the affected skin areas 1 time per day, preferably at night, and gently rub.

To achieve a satisfactory result, treatment should be continuous.

The duration of therapy is usually:

with foot mycoses (dermatophytosis of the foot skin and interdigital dermatophytosis of the feet): 3 weeks,
with mycosis of the hands (dermatophytosis of the skin of the hands and interdigital dermatophytosis), skin of the body (smooth skin dermatophytosis) and skin folds (inguinal dermatophytosis): 2-3 weeks,
with pityriasis, ehratrazme: 2 weeks,
with superficial candidiasis of the skin: 2-4 weeks.

To treat the surface of the skin approximately equal to the palm, a small amount of cream is sufficient (a column of cream about 1 cm long).

Side effect

pain in the application site;
peripheral edema (at the site of application);
contact dermatitis;
allergic dermatitis;
erythema;
itching;
rash;
hives;
blisters;
peeling and dry skin;
eczema;
skin irritation;
burning sensation of the skin.

Contraindications

hypersensitivity to bifonazole or any other component of the drug.

Carefully:

pregnancy and lactation;
childhood.

Application in pregnancy and lactation

Pregnancy

Absorption of bifonazole for external use of the drug is negligible. Research data show that Mycosorp does not have any negative effect on the body of the mother and fetus. However, the use of the drug during this period is possible if the potential benefit to the mother exceeds the potential risk to the fetus or the baby.

Lactation

It is not known whether bifonazole penetrates breast milk in women. Absorption of bifonazole for external use of the drug is negligible.However, the use of the drug during this period is possible if the potential benefit to the mother exceeds the potential risk to the fetus or the baby.

Fertility

The safety data obtained from preclinical studies suggest that the use of bifonazole does not have any negative effect on male and female fertility.

Use in children

There were no separate studies in children. Based on the review of clinical data, there is no evidence of adverse side effects in the use of the drug in children. However, in children younger than 1 year of age, Mikospor should be used only under the supervision of a doctor.

special instructions

Use with caution in patients who are hypersensitive to other antifungal drugs from the imidazole derivative group (econazole, clotrimazole, miconazole).

When sensitivity is increased in cetostearyl alcohol, it is recommended to use bifonazole dosage forms that do not contain cetostearyl alcohol (eg, Mycospore solution for external use 1%) instead of cream.

Avoid contact with eyes.

Drug Interactions

Absorption of bifonazole for external use of the drug is negligible. Cases of interaction with other drugs are unknown.

Analogues of the drug Mikospor

Structural analogs for the active substance:

Beefasam;
Bifonazole;
Bifonazole cream 1%;
Bifonazole powder 1%;
Bifonazole solution 1%;
Bifosin;
Mycospores Set.

Analogues for the pharmacological group (antifungal agents):

Amicon;
Amphotericin B;
Amfocil;
Antifungole;
Batrafen;
Binafin;
Voriconazole;
Ginezole 7;
Gynofort;
Diflucan;
Zalain;
Irunin;
Itraconazole;
Candide;
Ketoconazole;
Clion D 100;
Clotrimazole;
Lamisyl;
Levorin;
Livarol;
Loceril;
Mikamin;
Mikozolone;
Mycoterbine;
Natamycin;
Neo Penotran;
Nizoral;
Nystatin;
Orungal;
Pimafucin;
Rumikoz;
Safotsid;
Terbisyl;
Terbinafine;
Trozid;
Flucosan;
Fluconazole;
Flucostat;
Fukortsin;
Fulcin;
Fungoterbine;
Ekalin;
Exifin;
Exoderyl;
Eraksis.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: fungus, mycosis, lichen, thrush, onychomycosis, nail fungus, dermatophytosis, skin fungus, mycosis of brushes, candidiasis, pityriasis, erythrasma, candidiasis of the skin