Cavinton - instructions for use, reviews, analogs and formulations (tablets 5 mg, fort 10 mg, injections for injections and droppers) for the treatment of stroke and encephalopathy in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Cavinton. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cavinton in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cavinton in the presence of existing structural analogs.Use for the treatment of strokes, encephalopathies and other vascular disorders in adults, children, as well as during pregnancy and lactation.
Cavinton - a drug that improves cerebral circulation and brain metabolism. Active substance Vinpocetine.
Improves the metabolism of the brain, increasing the intake of glucose and oxygen by brain tissue. Increases the resistance of neurons to hypoxia; enhancing glucose transport to the brain, through the blood-brain barrier; translates the process of the decay of glucose into an energetically more economical, aerobic pathway; increases the levels of adenosine monophosphate (AMP) and cyclic guanosine monophosphate (cGMP) of the brain. Increases the concentration of ATP in the brain tissues; enhances the metabolism of noradrenaline and serotonin of the brain; stimulates the ascending branch of the noradrenergic system, has an antioxidant effect.
Reduces platelet aggregation and increased blood viscosity; increases the deforming ability of erythrocytes and blocks the utilization of adenosine by red blood cells; helps to increase the oxygen release of red blood cells.
Strengthens the neuroprotective effect of adenosine.
Increases cerebral blood flow; reduces the resistance of cerebral vessels without a significant change in the systemic blood circulation (BP, minute volume, heart rate, OPSS).
Does not have the effect of "stealing", increases blood supply, especially in ischemic areas of the brain with low perfusion.
Composition
Vinpocetine + auxiliary substances.
Indications
- reduction in the severity of neurological and mental symptoms in various forms of cerebral circulatory insufficiency (ischemic stroke, restorative stage of hemorrhagic stroke, consequences of a stroke, transient ischemic attack, vascular dementia, vertebrobasilar insufficiency, cerebral arteriosclerosis, posttraumatic and hypertensive encephalopathy);
- chronic vascular diseases of the choroid and retina (eg, thrombosis / occlusion / central artery or retinal vein);
- for the treatment of perceptual hearing loss, Meniere's disease, idiopathic tinnitus.
Forms of release
Tablets 5 mg.
Cavinton Fort 10 mg.
Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).
Instructions for use and dosage
Pills
Tablets are taken orally after eating.
The daily dose is 15-30 mg (5-10 mg 3 times a day). The initial daily dose is 15 mg. The maximum daily dose is 30 mg. The therapeutic effect develops about a week after the start of the drug. The course of treatment - 1-3 months.
In diseases of the kidneys and liver, the drug is prescribed in the usual dose, the absence of cumulation allows for long-term treatment.
Ampoules
The drug is intended for intravenous drip infusion (dropper). Enter slowly, the rate of infusion should not exceed 80 drops / min.
It is forbidden to enter intramuscularly and intravenously without dilution.
For the preparation of infusion, physiological saline or solutions containing Dextrose (Salsol, Ringer, Rindex, Reomacrodex) can be used. Infusion solution with Cavinton should be used within the first 3 hours after preparation.
The usual initial daily dose is 20-25 mg in 500 ml of the infusion solution.Depending on the tolerability, within 2-3 days the dose can be increased to no more than 1 mg / kg per day. The average duration of treatment is 10-14 days.
The average daily dose at a body weight of 70 kg is 50 mg (in 500 ml infusion solution).
With liver and kidney disease, dose adjustment is not required.
At the end of the course of intravenous therapy, it is recommended to continue Cavinton Forte tablets (1 tablet 3 times a day) or Cavinton (2 tablets 3 times a day).
Side effect
- ECG change (ST depression, QT interval prolongation);
- tachycardia;
- extrasystole (causal connection with taking the drug is not proven, because in the natural population these symptoms are observed with the same frequency);
- change in blood pressure (more often decrease);
- redness of the skin;
- sleep disorders (insomnia, increased drowsiness);
- dizziness;
- headache;
- general weakness (these symptoms may be manifestations of the underlying disease);
- dry mouth;
- nausea;
- heartburn;
- skin allergic reactions;
- increased sweating.
Contraindications
- acute phase of hemorrhagic stroke;
- severe form of ischemic heart disease;
- severe arrhythmias;
- pregnancy;
- lactation period;
- age under 18 years (due to insufficient data);
- known hypersensitivity to vinpocetine.
Application in pregnancy and lactation
The drug is contraindicated in pregnancy and lactation.
Use in children
Contraindicated in children under 18 years of age (due to insufficient data on the use of this age group).
special instructions
The presence of the syndrome of the prolonged QT interval and the use of drugs that cause prolongation of the QT interval requires periodic monitoring of the ECG.
Infusion solution Cavinton contains sorbitol (160 mg / 2 ml), therefore, in the presence of diabetes it is necessary to periodically check the blood glucose level.
In case of fructose intolerance or a deficiency of fructose 1,6-diphosphatase, Vinpocetine should be avoided.
Impact on the ability to drive vehicles and manage mechanisms
There is no information on the effect of vinpocetine on the ability to drive and work machinery.
Drug Interactions
With simultaneous application, no interaction with beta-blockers (chloranolol, pindolol), clopamid, glibenclamide, digoxin, acenocoumarol or hydrochlorothiazide is observed.
In rare cases, concomitant use with alpha-methyldopa is accompanied by a certain increase in the hypotensive effect, when using this combination, regular monitoring of blood pressure is necessary.
Despite the lack of data confirming the possibility of interaction, it is recommended to exercise caution when concurrently with the administration of central nervous, antiarrhythmic action.
Concentrate for the preparation of solution for infusions and Heparin are chemically incompatible, therefore it is forbidden to administer them in one infusion mixture, however, it is possible to simultaneously treat with anticoagulants and vinpocetine.
Concentrate for the preparation of a solution for infusions is incompatible with infusion solutions containing an amino acid, so they can not be used to dilute Cavinton.
Analogues of Cavinton
Structural analogs for the active substance:
- Bravinton;
- Vero-Vinpocetine;
- Vinpoton;
- Vinpocetine;
- Vinpocetine forte;
- Vincetin;
- Cavinton forte;
- Teletext.
Similar medicines:
Other medicines:
- Enterofuril - instructions for use, reviews, analogs and formulations (capsules 100 mg and 200 mg, suspension or syrup for ingestion) drugs for the treatment of diarrhea (diarrhea) in adults, children and pregnancy
- Diflucan - instructions for use, reviews, analogs and formulations (capsules 50 mg, 100 mg, 150 mg, suspension powder, ampoules) of the drug for treatment of candidiasis (thrush) in adults, children and pregnancy
- ATSTS - instructions for use, analogs, reviews and release forms (powder or granules for the preparation of syrup 100 mg, effervescent tablets 100 mg, 200 mg,600 mg long) of a drug for the treatment of bronchitis in adults, children and pregnancy