Next - instructions for use, analogs, reviews and release forms (pain medication tablets) for the treatment of pain, neuralgia and lowering of temperature in adults, children and pregnancy. Interaction with alcohol

In this article, you can read the instructions for using the drug Next. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nekst in their practice. A big request is to add more feedback about the pain medication: the medicine helped or did not help get rid of the disease, which complications and side effects were observed, possibly not stated by the manufacturer in the annotation. Analogues of Next if there are existing structural analogues. Use for the treatment of pain, neuralgia and lowering of temperature in adults, children, as well as during pregnancy and lactation. Interaction of the drug with alcohol.

Next - combined preparation, has analgesic, anti-inflammatory and antipyretic effect.

Paracetamol is a non-narcotic analgesic, has an antipyretic and analgesic effect due to blockade of cyclooxygenase in the central nervous system and exposure to pain centers and thermoregulation.

Ibuprofen is a non-steroidal anti-inflammatory agent that has analgesic, anti-inflammatory and antipyretic effects associated with a non-selective inhibition of cyclooxygenase activity regulating the synthesis of prostaglandins.

The components of the drug affect both the central and peripheral mechanisms of the formation of the pain syndrome. Directed, complementary action of the two components has a rapid therapeutic effect and a pronounced analgesic effect.

Composition

Ibuprofen + Paracetamol + excipients.

Pharmacokinetics

Paracetamol

Absorption is high. Penetrates through the blood-brain barrier. Metabolised in the liver, with the formation of both active and inactive metabolites. Primarily excreted by the kidneys in the form of metabolites - glucuronides and sulfates, 3% - unchanged.

Ibuprofen

It is well absorbed from the digestive tract.The connection with plasma proteins is 90%. The concentration of the drug in the synovial fluid exceeds the content in the plasma. Exposed to the systemic and post-systemic metabolism in the liver. It is excreted by the kidneys (in an unchanged form not more than 1%) and to a lesser extent - with bile.

Indications

• headache (including migraine);
• toothache;
• algodismenorea (painful menstruation);
• neuralgia;
• myalgia;
• back pain;
• joint pain, pain syndrome with inflammatory and degenerative diseases of the musculoskeletal system;
• pain with bruises, sprains, dislocations, fractures;
• post-traumatic and postoperative pain syndrome;
• feverish conditions (including influenza and colds).

Forms of release

The tablets covered with a cover.

Instructions for use and dosing regimen

Inside, after eating.

Adults: 1 tablet 3 times a day. The maximum daily dose is 3 tablets.

Children over 12 years of age (body weight over 40 kg): 1 tablet 2 times a day.

Duration of treatment no more than 3 days as an antipyretic agent and no more than 5 days - as an anesthetic. Continuation of treatment with the drug is possible only after consulting a doctor.

Side effect

• headache;
• dizziness;
• sleep disorders;
• anxiety;
• depression;
• tachycardia;
• increased blood pressure;
• heart failure;
• dyspnea;
• bronchospasm;
• abdominal pain;
• nausea, vomiting;
• heartburn;
• decreased appetite;
• diarrhea;
• constipation;
• flatulence;
• aphthous stomatitis;
• pancreatitis;
• hearing impairment;
• ringing or noise in the ears;
• visual impairment;
• blurred vision or diplopia;
• dryness and irritation of the eyes;
• acute renal insufficiency;
• nephrotic syndrome;
• cystitis;
• skin rash;
• itching;
• allergic rhinitis;
• angioedema;
• multi-form exudative erythema (including Stevens-Johnson syndrome);
• toxic epidermal necrolysis (Lyell's syndrome);
• anemia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia, eosinophilia;
• hemolytic anemia;
• aplastic anemia;
• methemoglobinemia;
• pancytopenia.

Contraindications

• hypersensitivity to the components of the drug;
• erosive and ulcerative diseases of the digestive tract (in the phase of exacerbation), gastrointestinal bleeding;
• severe hepatic and / or renal insufficiency;
• disorders of blood clotting (hemophilia, prolonged bleeding time, a tendency to bleeding, hemorrhagic diathesis);
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, incl. in the anamnesis;
• condition after aortocoronary bypass surgery;
• confirmed hyperkalemia;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy (3rd trimester);
• children under 12 years.

Application in pregnancy and lactation

If you need to use the drug in the first and second trimester of pregnancy, you should be careful - the application is only possible on the prescription of the doctor in cases where the potential benefit exceeds the possible risk. The use of the drug in the 3 trimester of pregnancy is contraindicated.

If breastfeeding is necessary, breast-feeding should be discontinued.

Use in children

Contraindicated in children under 12 years.

special instructions

It should be avoided simultaneous application of the drug with other drugs containing paracetamol and / or non-steroidal anti-inflammatory drugs.

When using the drug for more than 5-7 days, it is necessary to monitor the peripheral blood and the functional state of the liver.

Paracetamol distorts the results of laboratory studies of glucose and uric acid in the blood plasma.

When symptoms of NSAID-gastropathy appear, careful monitoring is performed, including esophagogastroduodenoscopy, a blood test with determination of hemoglobin and hematocrit, and analysis of feces for latent blood.

If it is necessary to determine 17-ketosteroids, Next should be discarded 48 hours before the study.

Against the background of taking the drug patients should refrain from all activities that require increased attention, rapid mental and motor reaction.

During the period of treatment, alcohol and alcohol-containing beverages are not recommended.

Drug Interactions

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which allows the development of severe intoxication in overdose.

Inhibitors of microsomal oxidation (incl.cimetidine) reduce the risk of hepatotoxic action.

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

The combination of Ibuprofen with ethanol (alcohol), glucocorticosteroids increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.

Simultaneous use of paracetamol with ethanol increases the risk of acute pancreatitis.

Paracetamol and ibuprofen increase the effect of anticoagulants of indirect action and reduce the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Ibuprofen reduces the hypotensive activity of vasodilators, natriuretic and diuretic - Furosemide and hydrochlorothiazide.

Antacids and colestyramine reduce the absorption of ibuprofen.

Ibuprofen enhances the effect of oral hypoglycemic agents and insulin.

Ibuprofen increases the concentration in the blood of digoxin, lithium and methotrexate.

With concomitant administration with acetylsalicylic acid, ibuprofen reduces its anti-inflammatory and antiaggregant effect.

Cefamandol, cefaperazone, cefotetan, valproic acid, plikamycin increase the frequency of hypoprothrombinemia.

Analogues of the medicinal product

Structural analogs for the active substance:

• Brustan;
• Ibuklin Junior;
• Ibuklin;
• Hyrumat.

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