Betagistin - instructions for use, analogs, reviews and release forms (tablets 8 mg, 16 mg and 24 mg) drugs for the treatment of dizziness, headache and Meniere's syndrome in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Betagistin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of experts on the use of Betagistin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Betagistin analogues in the presence of existing structural analogues. Use to treat dizziness, headache and Meniere's syndrome in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Betagistin - an antagonist of histamine H1 receptors in the vessels of the inner ear and an antagonist of histamine H3 receptors in the vestibular nuclei of the central nervous system. By relaxing precapillary sphincters of the vessels of the inner ear improves blood circulation in the vascular stria of the inner ear. It dose-dependently reduces the generation of action potentials in the neurons of the lateral and medial vestibular nuclei. Accelerates the recovery of the vestibular function after unilateral vestibular neurectomy, speeding up and facilitating central vestibular compensation (due to antagonism with histamine H3 receptors). It alleviates symptoms in Meniere's syndrome and vestibular dizziness. A stable therapeutic effect occurs after 14 days.

Composition

Betahistine dihydrochloride + excipients.

Pharmacokinetics

Absorbed quickly, binding to plasma proteins is low, less than 5%. Metabolized to inactive metabolites: 2-pyridylacetic acid (the main metabolite) and demethylbetahistine. Almost completely (85-90%) is excreted by kidneys in the form of a metabolite (2-pyridylacetic acid) for 24 hours. The excretion of betahistine and demethylbetahistine by the kidneys is insignificant.Only a small part of betagistin and its metabolites are excreted by the intestine.

Indications

• treatment and prevention of vestibular vertigo of various etiologies;
• syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea, vomiting;
• disease and Meniere's syndrome.

Forms of release

Tablets 8 mg, 16 mg and 24 mg.

Instructions for use and dosing regimen

Inside, with food.

Tablets 8 mg: 1-2 tablets 3 times a day.

Tablets 16 mg: 1/2 tablet 3 times a day.

Tablets 24 mg: 1 tablet 2 times a day.

The course of treatment is determined individually. Improvement is usually noted at the beginning of therapy, a stable therapeutic effect occurs after two weeks of treatment and may increase over several months of treatment. Treatment is long. Duration of drug intake is selected individually.

Side effect

• nausea, vomiting;
• dyspepsia;
• anaphylactic reactions;
• angioedema;
• skin rash;
• hives;
• angioedema;
• abdominal pain;
• bloating;
• itching.

Contraindications

• children under 18 years of age (due to lack of data);
• pregnancy;
• lactation period;
• hypersensitivity to one of the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy, because there is insufficient data to assess the effect of the drug on pregnant women and the fetus. During the lactation period, the drug should not be used, or during breastfeeding it is necessary to stop breastfeeding.

Use in children

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established);

special instructions

The therapeutic effect in a number of cases increases within a few months from the start of treatment.

With caution take with peptic ulcer of the stomach or duodenum (in the anamnesis), pheochromocytoma, bronchial asthma.

Impact on the ability to drive vehicles and manage mechanisms

Betagistin does not have a sedative effect and does not affect the ability to drive a car or work on machines and mechanisms.

Drug Interactions

Terfenadine reduces the effect of betagistin (possible return of labyrinthine symptoms); Care should be taken when concomitant use is indicated.

Against the background of hydroxyzine, the effect of betahistine is weakened.

Analogues of the drug Betagistin

Structural analogs for the active substance:

• Asnithon;
• Betaver;
• Betagistin hydrochloride;
• Betahistine dihydrochloride;
• Betaserc;
• Betacentrine;
• Vasoserk;
• Vestibo;
• Vestap;
• Denoise;
• The micrometer;
• Tagist.

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