ATSTS - instructions for use, analogs, reviews and release forms (powder or granules for the preparation of 100 mg syrup, effervescent tablets 100 mg, 200 mg, 600 mg long) of a drug for the treatment of bronchitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug ACC. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of ATSs in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of ATS in the presence of existing structural analogues. Use for the treatment of bronchitis and dry cough in adults, children,as well as during pregnancy and lactation. Various forms of release of the drug for liquefaction of sputum.

ACC mucolytic drug. The presence of sulfhydryl groups in the structure of the Acetylcysteine ​​molecule promotes rupture of disulfide bonds of acid mucopolysaccharides of sputum, which leads to a reduction in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the preventive use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Composition

Acetylcysteine ​​+ excipients.

Indications

• diseases of the respiratory system, accompanied by increased formation of viscous difficult-to-detach mucus (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);
• acute and chronic sinusitis;
• otitis media.

Forms of release

Powder or granules for the preparation of syrup 100 mg.

Syrup 100 ml.

Effervescent tablets 100 mg, 200 mg, 600 mg long.

Solution for Injection ATSTS inject - 100 mg and 300 mg in 1 ml.

Instructions for use and dosage

Powder or effervescent tablets

Adults and adolescents over 14 years of age are recommended to prescribe the drug 200 mg 2-3 times per day (ATSTS in the form of granules for the preparation of oral solution / orange / 100 mg and 200 mg) or 200 mg 3 (ACS in the form of granules for preparation solution for ingestion 200 mg) or 600 mg 1 time per day (ATSTS in the form of granules to prepare a solution for oral administration of 600 mg).

Children aged 6 to 14 years are advised to take 100 mg 3 times daily or 200 mg twice a day (ACS in the form of granules for oral solution / orange / 100 mg and 200 mg), or 200 mg 2 times a day (ATSTS in the form of granules for the preparation of a solution for oral administration of 200 mg).

For children aged 2 to 5 years, the drug is recommended to take 100 mg 2-3 times per day (ACS in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg).

There is insufficient data on the dosage of the drug in newborns.

In cystic fibrosis, children older than 6 years are recommended to take the drug at 200 mg 3 times per day (ACS in the form of granules for the preparation of oral solution / orange / 100 mg and 200 mg or ATSTS in the form of granules to prepare a solution for oral administration of 200 mg ).

Children aged 2 to 5 years - 100 mg 4 times a day (ATS in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg).

Patients with a body weight of more than 30 kg with cystic fibrosis, if necessary, can increase the dose to 800 mg per day.

With sudden short-term catarrhal diseases, the duration of admission is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be used for a longer period to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Rules for preparing the preparation

ACC in the form of granules for the preparation of oral solution / orange / 100 mg and 200 mg: 1/2 or 1 sachet (depending on the dose) is dissolved in water, juice or cold tea and taken after meals.

ACS in the form of granules for the preparation of a solution for oral administration of 200 mg and ATSTS in the form of granules for the preparation of a solution for oral administration of 600 mg: 1 packet is dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, leave the prepared solution for 3 hours.

Syrup

Adults and adolescents older than 14 years are prescribed 10 ml of syrup 2-3 times a day (400-600 mg of acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times a day or 10 ml of syrup 2 times a day (300-400 mg of acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times a day (200-300 mg of acetylcysteine).

In cystic fibrosis, children older than 6 years of drug should take 10 ml of syrup 3 times a day (600 mg of acetylcysteine); children aged 2 to 6 years - 5 ml of syrup 4 times a day (400 mg of acetylcysteine).

With short-term catarrhal diseases, the duration of admission is 4-5 days. In chronic bronchitis and cystic fibrosis, the drug should be used for a longer period to prevent infections. For long-term illnesses, the duration of therapy is determined by the attending physician.

The drug is taken orally after a meal. Additional fluid intake enhances the mucolytic effect of the drug.

Syrup ATSTS take with a measuring syringe or a measuring cup, located in the package. 10 ml of ACS syrup corresponds to 1/2 cup or 2 filled syringes.

Using a measuring syringe

1. Open the lid of the vial by pressing it and turning it counterclockwise.

2. Remove the plug with the syringe from the syringe, insert it into the neck of the vial and press it against the stop.The stopper is designed to connect the syringe with the vial and remains in the neck of the vial.

3. The syringe must be firmly inserted into the plug. Carefully turn the bottle upside down, pull the syringe plunger down and collect the required amount of syrup (ml). If air bubbles are visible in the syrup, press the piston against the stop, then refill the syringe. Then return the vial to its original position and remove the syringe.

4. Syrup from a syringe should be poured on a spoon or directly into the baby's mouth (in the cheek area, slowly, so that the child can swallow the syrup). When taking syrup, the child should be in a vertical position.

5. After use, wash the syringe with clean water.

Ampoules for injections

Adults are prescribed intravenously or intramuscularly 300 mg (1 ampoule) 1-2 times a day.

Children aged 6 to 14 years are prescribed IV or IV 150 mg (1/2 ampoules) 1-2 times a day.

For children under 6 years of age, oral therapy is preferred, however, in the presence of indications and the need for parenteral administration, the daily dose is 10 mg / kg body weight.

Children under the age of 1 year in / in the introduction of the drug is possible only for vital indications in a hospital.

The duration of therapy is determined individually.

With chronic bronchitis and cystic fibrosis, the use of ACTS INJECT for a long time can be combined with taking the drug inside to prevent infections.

The mucolytic effect of acetylcysteine ​​increases with increasing fluid intake.

The rules of injection

With the / m introduction with a shallow injection and with the presence of hypersensitivity, there may be a light and fast burning, so it is recommended to inject the drug in the prone position and deep into the muscle.

For intravenous administration, the first dose should be diluted with 0.9% sodium chloride solution or 5% Dextrose solution in a ratio of 1: 1. The drug should, if possible, be administered as an infusion.

In / in the injection should be done slowly (within 5 minutes).

Side effect

• headache;
• noise in ears;
• stomatitis;
• diarrhea;
• vomiting;
• heartburn;
• nausea;
• blood pressure drop;
• tachycardia;
• the development of pulmonary hemorrhage as a manifestation of the hypersensitivity reaction;
• bronchospasm (mainly in patients with a hyperreactive bronchial system in bronchial asthma);
• skin rash;
• itching;
• hives.

Contraindications

• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• hemoptysis;
• pulmonary hemorrhage;
• pregnancy;
• lactation period (breastfeeding);
• Children under 2 years of age (a preparation in the form of granules for the preparation of oral solution / orange / 100 mg and 200 mg, syrup and ACC 200);
• children's age till 6 years (the preparation in the form of granules for preparation of a solution for intake of 200 mg);
• children's age till 14 years (the preparation in the form of granules for preparation of a solution for oral administration 600 mg and ATSTS Long);
• hypersensitivity to acetylcysteine ​​and other components of the drug.

Application in pregnancy and lactation

Due to the lack of data, the use of the drug in pregnancy is contraindicated.

For syrup: use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Use in children

Contraindicated in children under 2 years of age (a drug in the form of granules for the preparation of oral solution / orange / 100 mg and 200 mg, syrup and ATSTS 200),up to 6 years (a drug in the form of granules for the preparation of a solution for ingestion of 200 mg), up to 14 years (a preparation in the form of granules for the preparation of oral solution 600 mg and ATSTS Long).

special instructions

In bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be administered with caution under systematic control of bronchial patency.

With the use of acetylcysteine, very rarely reported cases of severe allergic reactions, such as Stevens-Johnson syndrome and Lyell's syndrome. If skin and mucous membrane changes occur, the patient should immediately stop taking the medication and consult a doctor.

It is not recommended to prescribe the drug to patients with renal and / or liver failure to avoid additional formation of nitrogenous compounds.

When dissolving the drug should use glassware, avoid contact with metals, rubber, oxygen, easily oxidizable substances.

Do not take the drug immediately before bedtime (the preferred time of reception is before 6 pm).

With the development of side effects should be canceled taking the drug.

ATSTS (in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg) 100 mg corresponds to 0.24 XE, 200 mg to 0.23 XE.

Impact on the ability to drive vehicles and manage mechanisms

Information on the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions are absent.

Drug Interactions

With the simultaneous use of acetylcysteine ​​and antitussive drugs due to suppression of the cough reflex, a dangerous stagnation of mucus may occur (use the combination with caution).

With the simultaneous administration of ATSTS with vasodilators and nitroglycerin, vasodilating effect may be enhanced.

Synergy of acetylcysteine ​​with bronchodilators is noted.

ATSTS is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, Tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken inside no earlier than 2 hours after taking acetylcysteine.

Upon contact of acetylcysteine ​​with metals, rubber, sulphides with a characteristic odor are formed.

Analogues of drug ATSTS

Structural analogs for the active substance:

• N-AC-ratopharm;
• N-acetylcysteine;
• Acestin;
• Acetylcysteine;
• Acetylcysteine ​​SEDIKO;
• Acetylcysteine ​​solution for inhalation 20%;
• Acetylcysteine ​​injection 10%;
• Mukobene;
• The mukonist;
• Mukonakes;
• H-AC-ratopharm;
• Fluimucil;
• Exomuk 200.

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