Amelotex - instructions for use, analogs, reviews and release forms (tablets 7.5 mg and 15 mg, injections in ampoules for injections 1.5 ml, gel, suppositories) drugs for the treatment of arthritis and arthritis in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Amelotex. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Amelotex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Amelotex in the presence of existing structural analogues. Use for the treatment of arthrosis and rheumatoid arthritis in adults, children,as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Amelotex - non-steroidal anti-inflammatory drug (NSAID), has anti-inflammatory, antipyretic, analgesic effect.

Selectively inhibits the enzymatic activity of cyclooxygenase-2. Suppresses the synthesis of prostaglandins in the area of ​​inflammation to a greater extent than in the mucous membrane of the stomach or kidneys. Less often causes erosive and ulcerative lesions of the gastrointestinal tract.

Refers to the class of oxycomams; a derivative of enolic acid.

Pharmacokinetics

Binding to plasma proteins - 99%. Passes through the histogematic barriers, penetrates into the synovial fluid. It is excreted equally through the intestines and kidneys, mainly in the form of metabolites. Through the intestine unchanged output of less than 5% of the daily dose in the urine as unchanged drug is detected only in trace amounts.

Indications

• rheumatoid arthritis;
• osteoarthritis (arthrosis);
• ankylosing spondylitis (Bekhterev's disease);
• inflammatory and degenerative diseases of the joints, accompanied by pain syndrome.

Forms of release

Tablets 7.5 mg and 15 mg.

Solution for intramuscular injection (injections in ampoules for injection) 1.5 ml.

Gel for external use (sometimes mistakenly called ointment or cream).

Candles rectal 7.5 mg and 15 mg.

Instructions for use and how to use (how to stab the drug)

Pills

The drug is taken orally during meals once a day. The recommended dosage regimen for rheumatoid arthritis is 15 mg per day. Depending on the therapeutic effect, the dose can be reduced to 7.5 mg per day.

With osteoarthritis - 7.5 mg per day. If the dose is ineffective, it can be increased to 15 mg per day.

With ankylosing spondylitis 15 mg per day.

The maximum daily dose should not exceed 15 mg.

In patients with an increased risk of side effects, as well as in patients with severe renal failure who are on hemodialysis, the dose should not exceed 7.5 mg per day.

Ampoules

Intramuscularly, deeply - 7.5-15 mg once a day.

Patients with a slight or moderate decrease in renal function (QC greater than 25 ml / min), as well as with cirrhosis in a stable clinical condition, dose adjustment is not required. The initial dose in patients with an increased risk of side effects is 7.5 mg per day.

The maximum daily dose is 15 mg, in patients with severe renal failure who are on hemodialysis 7.5 mg.

Gel

Outwardly. Do not use inside.

A strip of gel about 4 cm long (2 grams) is applied twice a day with a thin layer on a clean dry skin over the lesion and slightly rubbed for 2-3 minutes.

The duration of the course of therapy is determined individually, it can vary depending on the site of the lesion and the observed therapeutic effect and is no more than 4 weeks.

Rectal Candles

Use 7.5-15 mg once a day.

The maximum daily dose is 15 mg.

Side effect

• nausea, vomiting;
• eructation;
• abdominal pain;
• constipation or diarrhea;
• flatulence;
• stomatitis;
• erosive and ulcerative lesions of the gastrointestinal tract;
• esophagitis;
• gastritis;
• colitis;
• gastrointestinal bleeding (latent or obvious);
• dizziness;
• headache;
• noise in ears;
• confusion of consciousness;
• drowsiness;
• bronchospasm;
• anemia, leukopenia, thrombocytopenia;
• peripheral edema;
• increased blood pressure;
• blood rushes to the skin of the face and upper chest;
• palpitation;
• increased urea concentration in blood serum;
• acute renal insufficiency;
• interstitial nephritis;
• albuminuria, hematuria;
• conjunctivitis;
• blurred vision;
• itching;
• skin rash;
• hives;
• photosensitization;
• bullous eruptions;
• erythema multiforme;
• toxic epidermal necrolysis;
• angioedema;
• anaphylactoid, anaphylactic reactions;
• possible burning and pain at the injection site.

Contraindications

• hypersensitivity to the active substance or ancillary components;
• contraindicated in the period after aortocoronary bypass surgery;
• uncompensated heart failure;
• complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including in the anamnesis);
• erosive and ulcerative changes in the mucosa of the stomach or duodenum, active gastrointestinal bleeding;
• inflammatory bowel disease (ulcerative colitis, Crohn's disease);
• cerebrovascular bleeding or other bleeding;
• severe hepatic impairment or active liver disease;
• marked renal failure in patients not undergoing dialysis (QC less than 30 ml / min);
• progressive kidney disease, incl. confirmed hyperkalemia;
• pregnancy;
• lactation period (breastfeeding);
• children's age till 15 years.

Application in pregnancy and lactation

Amelotex is contraindicated in pregnancy and lactation (breast-feeding).

Application in elderly patients

Used with caution in old age.

Use in children

Contraindicated in children and adolescents under the age of 15 years.

special instructions

In the event of peptic ulcers or gastrointestinal bleeding, the development of side effects from the skin and mucous membranes, the drug should be discarded.

In patients with reduced BCC and reduced glomerular filtration (dehydration, chronic heart failure, surgical operations), there may be a clinically pronounced chronic renal failure, which is completely reversible after discontinuation of the drug (in these patients, daily diuresis and renal function should be monitored).

With a persistent and significant increase in transaminases and changes in other indicators of liver function, Amelotex should be discarded and control tests performed.

In patients with an increased risk of side effects, treatment starts with a dose of 7.5 mg.

In the terminal stage of chronic renal failure in patients on dialysis, the dose should not exceed 7.5 mg per day.

Precautions: to reduce the risk of adverse events should use the minimum effective dose of the lowest possible short course in ischemic heart disease, cerebrovascular disease, congestive heart failure, dyslipidaemia / hyperlipidemia, diabetes, peripheral arterial disease, smoking, CC less than 60 ml / min, anamnesis on the development of ulcerative lesions gastrointestinal tract, in the presence of infection Helicobacter pylori, in the elderly, long-term use of NSAIDs, frequent alcohol consumption, severe somatic eskih diseases, concomitant therapy following drugs: anticoagulant (e.g., warfarin), antiplatelet agents (e.g. acetylsalicylic acid, clopidogrel) glucocorticosteroids (GCS) for ingestion (e.g. prednisolone), selective serotonin reuptake inhibitor (such as citalopram, fluoxetine, paroxetine, sertraline ).

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased concentration and speed of psychomotor reactions (with dizziness and drowsiness).

Drug Interactions

When used simultaneously with other non-steroidal anti-inflammatory drugs (NSAIDs), the risk of ulcerative gastrointestinal lesions and gastrointestinal bleeding increases.

Increases the concentration of lithium in plasma; reduces the effectiveness of intrauterine contraceptives, antihypertensive drugs.

Indirect anticoagulants, ticlopidine, heparin, thrombolytics increase the risk of bleeding; Methotrexate enhances myelodepressant effect; diuretics increase the risk of kidney dysfunction; cyclosporine increases nephrotoxicity; colestyramin accelerates excretion. Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Analogues of the drug Amelotex

Structural analogs for the active substance:

• Arthrosan;
• Bee-ksikam;
• Lem;
• M Kam;
• Matarin;
• Medsikam;
• Melbeck;
• Melbek forte;
• Meloks;
• Meloksam;
• Meloksikam;
• Meloflam;
• Meloflex Rompharm;
• Mesipol;
• Mixol Aud;
• Mirlocks;
• Movalis;
• Movasin;
• Movix;
• Oxycamox;
• Exen Sanovel.

Analogues on the curative effect (agents for the treatment of arthrosis):

• Ambien;
• Apizarthron;
• Artradol;
• Arthrosylen;
• Aertal;
• Hydrocortisone;
• Dexalgin;
• Diqlovit;
• Diclosan forte;
• Dicloran plus;
• Diclofenac;
• Dimexide;
• Dolgit;
• Indomethacin;
• Ketonal;
• Ketoprofen;
• Ketorol;
• Xsefokam;
• Longidase;
• Meloksam;
• Meloksikam;
• Midokalm;
• Movalis;
• Movix;
• Nyz;
• Naklofen;
• Nanoplast forte;
• Nimulid;
• Noltrex;
• Piroxicam;
• Rapten Duo;
• Sirdalud;
• Structum;
• Teraflex;
• Fendivia;
• Finalal;
• Flamax;
• Chondroxide;
• Celebrex;
• Elbona.

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