Phenibut - instructions for use, analogs, reviews and release forms (tablets 250 mg) drugs for the treatment of anxiety and neurotic disorders in adults, children and pregnancy
In this article, you can read the instructions for using the drug Fenibut. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Phenibut in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Phenibut in the presence of existing structural analogues. Use to treat anxious and neurotic disorders, alcoholism in adults, children, as well as during pregnancy and lactation.
Fenibut - nootropic agent, is gamma-amino-beta-phenylbutyric acid hydrochloride. It facilitates GABA-mediated transmission of nerve impulses to the central nervous system (direct effect on GABA receptors), also has a tranquilizing, psychostimulating, antiaggregant and antioxidant effect.
Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral circulation (increases the volume and linear speed of cerebral blood flow, reduces the tone of the vessels of the brain, improves microcirculation, and has antiaggregant effect). Promotes the reduction or disappearance of feelings of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect.
Does not affect cholino- and adrenergic receptors.
It prolongs the latent period and shortens the duration and severity of nystagmus.
Reduces the manifestations of asthenia and vasovegetative symptoms (including headache, a feeling of heaviness in the head, sleep disorders, irritability, emotional lability), increases mental performance.
It improves psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions).
At the course reception increases physical and mental efficiency, improves memory, normalizes sleep; improves the condition of patients with motor and speech disorders. In patients with asthenia, the state of health improves from the first days of therapy; increases interest and initiative (motivation of activity) without sedative action and excitement. When used after severe head injury, it increases the number of mitochondria in the perifocal areas and improves the course of bioenergetic processes in the brain.
With neurogenic lesions of the heart and stomach normalizes the processes of lipid peroxidation. In elderly people does not cause congestion and excessive lethargy, a relaxing aftereffect is most often absent. Improves microcirculation in the tissues of the eye, reduces the inhibitory effect of ethanol on the central nervous system. Malotoxic.
Pharmacokinetics
Absorption is high, it penetrates well into all tissues of the body and across the blood-brain barrier (about 0.1% of the injected dose penetrates the brain tissue, and to a much greater extent in young and elderly people). Evenly distributed in the liver and kidneys.Metabolized in the liver - 80-95%, metabolites are pharmacologically inactive. Do not cumulate (does not accumulate in the body). About 5% is excreted by the kidneys unchanged, in part - with bile.
Indications
- asthenic and anxiety-neurotic states;
- anxiety;
- fear;
- obsessive-compulsive disorder;
- psychopathy;
- stuttering and tics in children;
- enuresis;
- retention of urine in the background of myelodysplasia;
- Insomnia and nightmares in the elderly;
- prevention of anxiety conditions that arise before surgical interventions and painful diagnostic studies (premedication);
- Meniere's disease;
- dizziness associated with dysfunctions of the vestibular analyzer of various genesis (including in the otogenous labyrinthitis, vascular and traumatic disorders);
- prevention of motion sickness with kinetosis;
- primary open-angle glaucoma (as part of combination therapy);
- as an auxiliary therapy in the treatment of alcoholism (for the relief of psychopathological and somatovegetative disorders with abstinence syndrome);
- treatment of pre-delirious and delirious states with alcoholism (in combination with conventional detoxification agents).
Forms of release
Tablets 250 mg.
Instructions for use and dosage
Inside, regardless of food intake. The dose, the frequency of treatment and the duration of treatment depend on the indications, age of the patient, tolerability. A single dose for adults varies from 20 mg to 750 mg, for children from 20 mg to 250 mg.
Side effect
- increased irritability
- excitation
- anxiety
- dizziness
- headache
- drowsiness
- nausea (at the first reception)
- skin rash
- itching.
Contraindications
- increased sensitivity to Phenibutus.
Application in pregnancy and lactation
Use with caution in pregnancy, during lactation.
special instructions
C use with caution in erosive and ulcerative lesions of the digestive tract, liver failure.
With prolonged use, it is necessary to monitor the liver function and the peripheral blood picture.
It is not effective at the expressed phenomena of motion sickness (including indomitable vomiting, dizziness).
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period it is necessary to refrain from potentially dangerous activities requiring increased attention and high speed of psychomotor reactions.
Drug Interactions
Extends and enhances the effect of sleeping pills, narcotic analgesics, antiepileptic, antipsychotic and anti-Parkinsonian drugs.
Analogues of the drug Fenibut
Structural analogs for the active substance:
- Anvifen.
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