En DE FR ES PL
Concor - instructions for use, reviews, analogs and forms of release (5 mg, 10 mg, 2.5 mg Kor) medications for the treatment of blood pressure, CHD, heart failure in adults, including during pregnancy. Side effect

Concor - instructions for use, reviews, analogs and forms of release (5 mg, 10 mg, 2.5 mg Kor) medications for the treatment of blood pressure, CHD, heart failure in adults, including during pregnancy. Side effect

In this article, you can read the instructions for using the drug Concor. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Concor in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Concor in the presence of existing structural analogues. Use for the treatment of hypertension, IHD, stable angina and heart failure in adults,as well as during pregnancy and lactation. Side effect and the use of alcohol with medicine.

 

Concor - selective beta1-adrenoblocker, without its own sympathomimetic activity, does not have a membrane-stabilizing action.

 

Has only a slight affinity for beta2-adrenoreceptors of smooth muscles of bronchi and vessels, as well as for beta2-adrenoreceptors involved in the regulation of metabolism. Therefore, Bisoprolol (the active substance of the Concor preparation) generally does not affect the resistance of the respiratory tract and the metabolic processes in which beta2-adrenergic receptors are involved.

 

The selective effect of the drug on beta 1-adrenergic receptors persists beyond the therapeutic range.

 

Bisoprolol does not have a pronounced negative inotropic effect.

 

Bisoprolol reduces the activity of the sympathoadrenal system by blocking the beta 1-adrenergic receptor of the heart.

 

With a single oral intake in patients with IHD without signs of chronic heart failure, bisoprolol reduces heart rate, reduces stroke volume of the heart and, as a result, reduces the ejection fraction and myocardial oxygen demand. With prolonged therapy, the initially increased OPSS decreases.Reduction of renin activity in blood plasma is considered as one of the components of antihypertensive action of beta-blockers.

 

The maximum effect of the drug is achieved 3-4 hours after ingestion. Even with the appointment of bisoprolol 1 time per day, its therapeutic effect persists for 24 hours due to the fact that its T1 / 2 from the blood plasma is 10-12 hours. As a rule, the maximum decrease in blood pressure is achieved 2 weeks after the start of treatment.

 

Pharmacokinetics

 

After ingestion, Concor almost completely (> 90%) is absorbed from the digestive tract. Eating does not affect bioavailability. Bisoprolol clearance is determined by the balance between excretion by the kidneys in an unchanged form (about 50%) and metabolism in the liver (about 50%) to metabolites that are also excreted by the kidneys.

 

Indications

  • arterial hypertension;
  • IHD: stable angina;
  • chronic heart failure.

 

Forms of release

 

Tablets coated with 5 mg and 10 mg.

 

Tablets coated with 2.5 mg (Concor Cor).

 

Instructions for use and dosage

 

The drug is taken orally once a day. Tablets should be taken with a small amount of liquid in the morning before breakfast, during or after it.Tablets should not be chewed or ground into a powder.

 

Arterial hypertension and angina pectoris

 

The dose is selected individually, primarily taking into account the heart rate and the patient's condition.

 

As a rule, the initial dose is 5 mg once a day. If necessary, the dose can be increased to 10 mg once a day. In the treatment of hypertension and angina, the maximum recommended dose is 20 mg once a day.

 

Chronic heart failure

 

The standard treatment regimen for chronic heart failure includes the use of ACE inhibitors or angiotensin 2 receptor antagonists (in the case of intolerance to ACE inhibitors), beta-blockers, diuretics and, optionally, cardiac glycosides. At the beginning of the treatment of chronic heart failure, Concor requires a special phase of titration under regular medical supervision.

 

A precondition for the treatment with Concor is a stable chronic heart failure without signs of exacerbation.

 

Treatment with Concor begins with the following titration scheme.Individual adaptation may be required depending on how well the patient tolerates the prescribed dose, i.e., the dose can be increased only if the previous dose is well tolerated.

 

To ensure the appropriate titration process at the initial stages of treatment, it is recommended to use bisoprolol in the dosage form of a 2.5 mg tablet.

 

The recommended initial dose is 1.25 mg once a day. Depending on the individual tolerability, the dose should be gradually increased to 2.5 mg, 3.75 mg, 5 mg, 7.5 mg and 10 mg once daily. Each subsequent increase in the dose should be carried out at least 2 weeks later. If the increase in the dose of the drug is poorly tolerated by the patient, then a dose reduction is possible.

 

The maximum recommended dose for the treatment of chronic heart failure is 10 mg once a day.

 

During titration, regular monitoring of blood pressure, heart rate and degree of symptoms of chronic heart failure is recommended. The worsening of the symptoms of the course of chronic heart failure is possible already from the first day of application of the drug.

 

If the patient does not tolerate the maximum recommended dose of the drug, then the possibility of a gradual dose reduction should be considered.

 

During the titration phase or after it, temporary deterioration of the course of chronic heart failure, arterial hypotension or bradycardia is possible. In this case, it is recommended, first of all, to correct the doses of concomitant therapy. It may also require a temporary reduction in the dose of Concor or its cancellation. After stabilization of the patient's condition, a repeated titration of the dose should be performed, or the treatment should be continued.

 

Duration of treatment for all indications

 

Treatment with Concor is usually long-term.

 

Older patients do not need a dose adjustment.

 

Because There is not enough data on the use of Concor in children, it is not recommended to prescribe the drug to children under 18 years of age.

 

To date, there is insufficient data on the use of Concor in patients with chronic heart failure in combination with type 1 diabetes mellitus, expressed by impaired renal and / or liver function,restrictive cardiomyopathy, congenital heart disease or heart valve disease with severe hemodynamic disorders. Also, sufficient data have not yet been obtained regarding patients with chronic heart failure with myocardial infarction during the last 3 months.

 

Side effect

  • bradycardia (in patients with chronic heart failure);
  • exacerbation of symptoms of chronic heart failure (in patients with chronic heart failure);
  • a feeling of cold or numbness in the limbs;
  • marked decrease in blood pressure (especially in patients with chronic heart failure);
  • orthostatic hypotension;
  • dizziness;
  • headache;
  • loss of consciousness;
  • depression;
  • insomnia;
  • hallucinations;
  • reduction of tearing (should be considered when wearing contact lenses);
  • hearing impairment;
  • conjunctivitis;
  • bronchospasm in patients with bronchial asthma or obstructive airways disease in the anamnesis;
  • nausea, vomiting;
  • diarrhea, constipation;
  • muscle weakness;
  • muscle cramps;
  • violation of potency;
  • itching;
  • rash;
  • hyperemia of the skin;
  • allergic rhinitis;
  • asthenia (in patients with chronic heart failure);
  • increased fatigue.

 

Contraindications

  • acute heart failure;
  • chronic heart failure in the stage of decompensation, requiring treatment with drugs with a positive inotropic effect;
  • cardiogenic shock;
  • AV-blockade of 2 and 3 degrees, without the pacemaker;
  • SSSU;
  • sinoatrial blockade;
  • marked bradycardia (heart rate <60 bpm);
  • marked decrease in blood pressure (systolic blood pressure <100 mmHg);
  • severe forms of bronchial asthma and COPD in history;
  • severe violations of peripheral arterial blood circulation, Raynaud's disease;
  • pheochromocytoma (without simultaneous use of alpha-blockers);
  • metabolic acidosis;
  • age under 18 years (insufficient data on efficiency and safety);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The use of Concor in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.

 

Beta-adrenoblockers reduce blood flow in the placenta and can affect the development of the fetus.Blood flow in the placenta and uterus should be carefully monitored, and the growth and development of the unborn child should be monitored, and alternative therapeutic measures taken in case of undesirable manifestations in relation to pregnancy or fetus. You should carefully examine the newborn after delivery. In the first 3 days of life, bradycardia and hypoglycemia may occur.

 

There is no data on bisoprolol and breast milk. Concor is not recommended for women during lactation. If you need to use the drug during lactation, breastfeeding should be discontinued.

 

special instructions

 

The patient should not abruptly discontinue treatment and change the recommended dose without first consulting a doctor, as this can lead to a temporary deterioration in the heart. Treatment should not be interrupted suddenly, especially in patients with ischemic heart disease. If discontinuation of treatment is necessary, the dose should be reduced gradually.

 

Three - and tetracyclic antidepressants, antipsychotics (antipsychotics), ethanol (alcohol), sedative and hypnotic drugs increase the depression of the central nervous system.

 

At the initial stage of treatment with Concor, patients need constant medical supervision.

 

Caution should be used in patients with diabetes mellitus with significant fluctuations in blood glucose (symptoms of severe hypoglycemia, such as tachycardia, palpitations or excessive sweating may be masked), in patients on a strict diet, with desensitizing therapy, AV-blockade 1 degree , Prinzmetal angina, violations of peripheral arterial blood flow of mild and moderate degree (at the beginning of therapy there may be an increase in symptoms), with psoriasis (including anamn eze).

 

Respiratory system: with bronchial asthma or COPD, simultaneous application of bronchodilating agents is indicated. In patients with bronchial asthma, an increase in airway resistance may be required, which requires a higher dose of beta2-adrenomimetics.

 

Allergic reactions: beta-adrenoblockers, including Concor preparation, can increase sensitivity to allergens and the severity of anaphylactic reactions due to weakening of adrenergic compensatory regulation under the action of beta adrenoblockers. Epinephrine (epinephrine) therapy does not always produce the expected therapeutic effect.

 

When conducting general anesthesia, the risk of blockade of beta-adrenergic receptors should be considered. If it is necessary to discontinue therapy with Concor before surgery, it should be done gradually, and completed 48 hours before the general anesthesia. An anesthetist should be warned that the patient is taking Concor.

 

In patients with pheochromocytoma, Concor can be prescribed only against the background of the use of alpha-blockers.

 

When treated with Concor, the symptoms of hyperthyroidism may be masked.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Concor does not affect the ability to drive vehicles according to the results of the study in patients with ischemic heart disease. However, due to individual reactions, the ability to drive a car or work with technically complex machinery can be disrupted. This should be paid special attention at the beginning of treatment, after changing the dose, as well as with the simultaneous use of alcohol.

 

Drug Interactions

 

The effectiveness and tolerability of bisoprolol may be affected by the simultaneous use of other drugs.This interaction can also occur when two drugs are taken in a short time. The physician should be informed about the use of other medicines, even if the application is carried out without a prescription.

 

Unrecommended combinations

 

Treatment of chronic heart failure

 

Class 1 antiarrhythmics (eg, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone), while being used with bisoprolol may reduce AV conduction and contractility of the heart.

 

All indications for the use of the drug Concor

 

Blockers of slow calcium channels like Verapamil and, to a lesser extent, diltiazem, with simultaneous application with bisoprolol can lead to a decrease in myocardial contractility and disturbance of AV conduction. In particular, intravenous administration of verapamil to patients taking beta-blockers can lead to severe arterial hypotension and AV blockade. Hypotensive agents of central action (such as clonidine, methyldopa, moxonidine, rilmenidine) can lead to a decrease in heart rate and a decrease in cardiac output, as well as to vasodilation due to a decrease in the central sympathetic tone.Abrupt cancellation, especially before the abolition of beta-blockers may increase the risk of developing "ricochet" hypertension.

 

Combinations requiring special care

 

Treatment of arterial hypertension and angina

 

Antiarrhythmic drugs of the first class (eg, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone) with simultaneous application with bisoprolol may reduce AV conduction and contractility of the myocardium.

 

All indications for the use of the drug Concor

 

Slow calcium channel blockers, dihydropyridine derivatives (eg, nifedipine, felodipine, amlodipine) with simultaneous use with bisoprolol may increase the risk of developing hypotension. In patients with chronic heart failure, the risk of subsequent deterioration of the contractile function of the heart can not be ruled out.

 

Antiarrhythmic drugs of the third class (for example, amiodarone), when used concomitantly with Concor, may increase the disturbance of AV conduction.

 

The action of beta-blockers for topical application (eg, eye drops for the treatment of glaucoma) can enhance the systemic effects of bisoprolol (lowering blood pressure, reducing heart rate).

 

Parasympatomimetics with simultaneous application with bisoprolol may increase the disturbance of AV conduction and increase the risk of developing bradycardia.

 

When used concomitantly with the drug Concor may increase hypoglycemic action of insulin or hypoglycemic agents for oral administration. Symptoms of hypoglycemia, in particular tachycardia, can be masked or suppressed. Such interaction is more likely when using non-selective beta-blockers.

 

Means for general anesthesia can increase the risk of cardiodepressive action, leading to arterial hypotension.

 

Cardiac glycosides with simultaneous application with bisoprolol may lead to an increase in the timing of the impulse, and thus to the development of bradycardia.

 

Nonsteroidal anti-inflammatory drugs (NSAIDs) are able to reduce the hypotensive effect of Concor.

 

Concurrent use of Concor with beta-adrenomimetics (eg, isoprenaline, dobutamine) can lead to a decrease in the effect of both drugs.

 

The combination of bisoprolol with adrenomimetics that affect alpha and beta-adrenergic receptors (eg, norepinephrine,epinephrine) can enhance the vasoconstrictor effects of these drugs, due to the effect on alpha-adrenergic receptors, leading to an increase in blood pressure. Such interaction is more likely when using non-selective beta-blockers.

 

Antihypertensives, as well as other agents with a possible antihypertensive effect (for example, tricyclic antidepressants, barbiturates, phenothiazines) can enhance the hypotensive effect of bisoprolol.

 

Mefloquine with simultaneous application with bisoprolol can increase the risk of bradycardia.

 

MAO inhibitors (with the exception of MAO B inhibitors) can enhance the antihypertensive effect of beta-blockers. Simultaneous application can also lead to the development of hypertensive crisis.

 

Analogues of Concor drug

 

Structural analogs for the active substance:

  • Aritel;
  • Aritel Cor;
  • Bidop;
  • Biol;
  • Biprol;
  • Bisogamma;
  • Bisocardium;
  • Bisomore;
  • Bisoprolol;
  • Bisoprolol-Lugal;
  • Bisoprolol-Prana;
  • Bisoprolol-ratopharm;
  • Bisoprolol-Teva;
  • Bisoprolol hemifumarate;
  • Bisoprolol fumarate;
  • Concor Cor;
  • Corbis;
  • Cordinorm;
  • Coronale;
  • Niperten;
  • Thyrez.

Similar medicines:

Other medicines:
Reviews (98):
Guests
jungle
A good modern drug against pressure and ischemia. If there are problems at the same time with both, and with the other (usually go together), then the best medicine and not come up. Packing costs 300 rubles. Take pills in the form of hearts you need 1 time per day. Dosage is different and appoint a doctor, self-medication is best not to deal with.
Guests
Svetlana
The drug helps, but why doctors always write out expensive and that there are cheap analogs, are silent? Or the analogue is worse? Konkor at us costs 380 rubles, and Bisoprolol 60 rubles. If there is no difference, why pay more? Or is something wrong? I can not understand this.
Administrators
admin
Svetlana, there are drugs, among which cheap generics (analogs) are worse than expensive ones. In a specific example on two drugs, I did not particularly notice the difference in the appointment. Both medications helped equally, and if there was a side reaction to bisoprolol, then she was also present at Concor.
Guests
Goose
Has had the misfortune of a 12-day reception of Bisoprolol instead of a perennial Concor. This is how to change seats after a Mercedes in Zaporozhets - a double dose (5mg B. instead of 2.5mg K.) did not lower the pulse below 70-80 (at K. 55-65 is stable) and a two-time reception. So, this rubbish is B.
Guests
Love
The drug is very helpful and with angina pectoris, but you must carefully apply and choose for yourself a dosage.
Guests
ilham
Have you seen a decrease in libido?
Administrators
admin
ilham, Violation of potency is noted as one of the side effects of the drug Concor. So this is quite acceptable, but it is not worth it to be tolerated, but it is better to consult a doctor who prescribes this drug.
Guests
lads
I accept 3 years. Have appointed or nominated from a tachycardia. It became better, but there was shortness of breath, conjunctivitis. I'm trying to get down slowly.
Guests
Tatyana
Concor with enapom appointed, the pressure was, the pressure decreased, but the pulse became low, the concor is good, apparently, you only need to select the right dose!
Guests
Svetlana
I accept Concor Cor 2 years, I was discharged from tachycardia, at the beginning I was tortured by dreams - no nights without sleep, it seemed to be tightening up - or maybe just became calmer. But the pressure is 120 to 80, and after physical exertion, flight, stress. If I forget to drink a pill, then I immediately feel it.
Visitors
VeteranDolga
I accept Concor about 3 years, perfectly reduces heart rate, especially after a meal., 5 ml. a day after lunch. Sleep normal, but the potency, it seems to me, the drug still somehow affects. And in general, the drug is very good.
Guests
Vasya
Raises the potency perfectly.
Guests
Olesya
And at me for the first time for all my years of a life the menstrual cycle was broken, more precisely-these tablets have provoked again "that", that one week ago has stopped ... Anything, except for Concor I did not use. Perhaps this is not associated with it, I did not find anything similar in side-effects, but I decided to write it all, suddenly someone also had it.
Administrators
admin
Olesya, Such drugs as Concor, affecting the vascular component and regulation, can lead to violations of the menstrual cycle, even if this is not explicitly stated in the instructions.
Guests
tamara
At the onset of menopause, attacks of tachycardia became more frequent, the pressure jumped, the doctor prescribed cancers, drank somewhere six months, and then the pharmacist offered a cordonorm, cheaper, I take this drug for 3 years, there is no difference, and in price it is very noticeable)))
Guests
Tatyana
I drink 15 days. Attached by a cardiologist in a dose of 5 mg to reduce blood pressure (max 160/100) and to reduce the huss (max.102). The pulse does not exceed 80, the pressure does not exceed 130/75, but there is dizziness. I began to feel like on a ship, not only when walking, but lying and sitting. I also take vazobral on 1 tab. and a cardiomagnesium 75 mg.
Administrators
admin
TatyanaIf dizziness is very uncomfortable, then you need to change the treatment schedule.If you wrote that the head is spinning a day or two after the start of treatment, then this is normal for drugs that regulate the rhythm or pressure, but for two weeks as in your case, such symptoms should have passed. So this is the reaction of your body to one of the drugs, maybe to Concor.
Guests
Basil.
I accept Concor more than 3 years. Doprimanalsya. Hello Diabetes. Sugar 12 on an empty stomach.
Guests
Guru
The pressure normalizes quickly, but the pulse drops to 40. The doctor canceled says it's dangerous!
Guests
lemon_chik
Vasily agrees with you at me similarly, and even a terrible eruption on legs, at last, itself has found out, that from konkora.
Guests
zinaide
I take lapaz plus. Can I take Concor?
Administrators
admin
zinaide, These are two different drugs. Lozap plus - blocker of angiotensin 2 receptors + diuretic, and Concor - beta-blocker. So contact the therapist, and it is better to the cardiologist to assess the need for such a replacement.

If you want to take both drugs together, they are combined and in the instructions there is no indication of negative mutual side effects when taken together. One has only to pay attention to that Concor also slightly reduces blood pressure, so that there is not too rapid a drop in such a combination.
Guests
Angelina
I accept the concor from 2006 on tachycardia (pulse during the attack 100-140уд.) Prescribed by the arrhythmic doctor. All these 8 years against the background of the concore felt good (pulse 60-80уд "). At the beginning of January this year, against the background of concor again began to worry tachycardia with breathing 1-2 times a day. The slightest load and immediately tachycardia (100-120). What to do?...
Administrators
admin
Angelina, Visit a doctor. At best, Conkor's usual dosage was no longer sufficient; at the worst, a new disease or heart condition was added, which leads to outbreaks of tachycardia.
Guests
Larissa
Due to inflammation of the stomach, I could not drink a usual dose of concord for two days.On the first day I could not understand why my head and terrible anxiety split. On the employee's day a similar "breaking". Nearly died. No, gentlemen, Europeans, drink your own medication yourself, and we will save ourselves.
Guests
Sergey Leonidovich 63 b.r.
The drug is good. Took a few years. There were almost no side changes. Only the time of getting used a couple of weeks. Before taking the medication, there were all signs of IHD, although the monitoring did not confirm anything. After the beginning of the reception, life improved qualitatively. Over time, the pain resumed, the ECG deteriorated. Have written Betalok ZOK. Sensations at first were not ordinary, as if there was no heart at all. The ECG became worse, and the doctor said, you see, now it's better. I think they deliberately calm everyone and never tell the truth. To see at cardiologists it so is got.
Administrators
admin
Sergey Leonidovich 63 b.r., I think with malice, no one tells you this. Yes, some doctors are incompetent and instead of solving the problem blunder it. Sometimes diagnoses and their combinations of patients really puzzle even experienced doctors, for example, an allergy to all medicines and something you need to treat the patient.You have to pick up gradually, but all this time the patient will suffer and nothing can be done about it.
Guests
Savia Zinnatovna
Concor I take more than 5 years (5 mg). Discomfort did not feel. Only recently I feel that the drug is not enough for 24 hours. For the evening, the pressure is rising again. I tried to add a dose, ie, 10 mg, the heart rate decreases, less than 60.
Visitors
Anatoly
At me from 3 up to 10 times a month there is an arrhythmia. Previously, too, was, but without inconvenience, but now quite unpleasant sensations. Doctors either can not catch it on a cardiogram, there is no cure. Friends advised concor 5 mg, 1 time per day. Attacks became less frequent. I take 3 months, tried to quit. After 2 days I felt pain in the heart. I heard that I need a break in the reception, but it turned out worse. Do I need to drink all my life?
Administrators
admin
Anatoly, Usually, drugs to reduce pressure and regulate heart rhythm take a very long or lifelong (if they are suitable for the patient and do not give side effects).You could see this in your own experience, when they canceled Concor and the negative reactions returned. I advise nevertheless to address to the cardiologist, he should catch a failure of a rhythm, for this purpose it is possible to spend daily monitoring and then already to diagnose and appoint treatment of a concrete problem.
Guests
Anife
I accept Concor 2.5 years. The pressure does not increase. There were no side effects. Only I take in the evening, because in the morning the pressure after taking was low.
Guests
Irina
I accept Concor 2.5 for almost a month and amlipin 5 on the floor of the pill, the pressure drops to 105/70, (it was 150, 160/105 and the crisis is 210/110), but with low pressure, too, I do not feel very well: my head is spinning. Probably, it is necessary to stay on one thing.
Guests
boris
I accept Concor 2 years, sugar rose to 12, the potency completely disappeared. I accept, together with cordaflex, the pressure became normal.
Guests
Love
2 years I accept Concor 2.5 and in the evening Noliprel 2.5. There was a strong cough and chest pain. With the cancellation of noliprel, there is not enough for a day of a concourse. In the evening, the pressure rises.
Visitors
F.Andrey
Hello. The therapist has appointed or nominated to me konkor and enalapril from pressure (on reception was 170-100), and at me an atherosclerosis of the bottom extremities of 2 tbsp. Should I take Concor or is it better to replace it with another drug?
Administrators
admin
F.AndreyAnd why did not you like Konkor in the treatment scheme? Many hypertensive patients have concomitant sclerotic vascular disease, but no one has yet complained to Concor. In addition to standard situations, when the drug is not suitable and there are side effects, stated in the instructions, then you have to cancel or change the medicine. But from the latter no one is immune, even a person with healthy blood vessels.
Visitors
F.Andrey
Thanks for the answer. Since I use concor, distance of walking began to decrease, for a year from 500 m to 250 m. I used to not pay attention to contra-indications, I recently read it, so I turned to you.
Guests
hope for
Hello dear comrades! The cardiologist to me has appointed or nominated konkor 5 mg, enalapril 10 mg 2 times a day, krestor 10 mg 1 tab. in the evening. Became to take side effects appeared a lot: dizziness, lost sleep, nausea, diarrhea.
Guests
olga
Concor is a very strong drug. If there are no chronic disorders or the initial disease is not worth such a drug to drink. At me during reception at once the palpitation 55 strokes in a minute decreased. Strong pains were in the breasts. A menopause disorder has occurred. And I continued to drink, not knowing what was happening to me. It's the doctor's appointment. That's how we are treated for a fee. I stopped drinking Concor with caution. It's impossible to stop sharply. Be very careful in taking this medication. I wish everyone good health.
Visitors
michaelal
I have an old mother. She is 85 years old. In my whole life, I almost did not get sick. Is that a cold, and then rarely. But recently she felt sick. They called an ambulance. It turned out, high blood pressure. 210 \ 85. Have appointed or nominated treatment - tablets. In the morning, cardiomagnesium, concor 2.5, indapamide 2.5 and mexidol 0.125. In the evening, Concor 2.5, mexidol 2.5 and waltz - 80.Is it too much immediately? Moreover, as I understand, some perform the same function. Is it possible to exclude at least a concor? All these drugs are taken within 3 months. During this time, she was under pressure a couple of times, as we noticed when the weather changed.
Administrators
admin
michaelalSo I did not understand - it did not hurt anything, it takes a bunch of drugs from pressure and to regulate the heart rhythm or it takes 3 months all this complex after the pressure jump and it (the pressure) still jumps, then it is necessary either to increase the dosage, or to change preparations on others. In general, with such a bouquet of medicines, you only need to see a full-time doctor, not an ambulance, but a district doctor who observes your mother for correction of therapy, because pressure jumps at her age are very dangerous and can lead to deplorable consequences, of which the most formidable are stroke and a heart attack. Remotely we will not solve anything, too age patient and there will be many nuances for treatment (this is from experience).
Guests
SergeyM
I drink concor 2.5 on half a tablet daily in the morning for 2 years.Often there is a giddiness, an internal dyscomfort (disturbance any). The therapist has written out to me these tablets not looking, ie. measured the pressure, wrote something and wrote out a prescription. Everything says, now drink for life. And before that, I had a pressure of 160/110. The attitude of the therapists, as to the unsubscribe, needs to be completed in 10 minutes, the diagnosis and prescriptions are prescribed by template, without any analysis, go and "eat" that they wrote out.
Guests
zachary
I accept Concor 2.5 since the 90s and I do not observe any side effects. The drug is good, I have no complaints against it.
Administrators
admin
Question from the site visitor Sv1970 moved to the required section:
In connection with the transition to reception Concorcore (after anaprilina, from which they went for some reason), I have a question: as read in the instructions, Concor-Cor can cause heart failure? Can he cause dyspnea at rest with a dry cough? We took 1.25 in the morning, take 3 months, feel normal, but twice there were attacks of CH, which had never happened before. Maybe, of course, a coincidence, but maybe,It is the drug that aggravated the situation? The attending physician ordered to drink it further, moreover - added 2.5 mg of Concor-Cora at night, atoris 10 mg, riboxin with panangin, and Accecaradol. I ask to resolve doubts - could the drug cause CH, and whether to continue taking it in a dose, now it turns out, 3.75 mg? Thank you!

Sv1970, All right to you appointed doctor, because Concor Cor is used to treat chronic heart failure, which apparently had a place to be in the patient. A worsening of the symptoms of the disease, probably due to an insufficient dosage of the drug, this time and corrected the attending physician, increasing the dose of tablets. Side effects in the form of increased symptoms of insufficiency when taking Concor are possible, but in the first hours or days of taking this medication, and not after a week or a month. In any case, a detailed picture of the patient's health and treatment should be obtained from his doctor. While special moments do not trust him I'm from the description of the problem I do not see.
Visitors
Sv1970
Thank you very much for your reply! Yes, the doctor is very good, just a lot of patients, and not always remember what to ask, questions arise only afterwards.Accept Concor Cor in the prescribed dosage from yesterday evening, while shortness of breath and dry cough persists. Please, answer, can shortness of breath and cough persist for 2 days, incl. - and at rest? The doctor said that these symptoms will go away by themselves, thanks to the reception of blockers ... Will they pass? And how to relieve the condition, because it has never happened before? It's just very contradictory responses from patients about this drug, which differ drastically. Thank you in advance, and all the best!
Administrators
admin
Sv1970, Two days is no time for which you can evaluate the work of the drug. Dyspnoea may be due to the disease, and the effect of taking the drug. If the doctor raises the dosage, then he sees that the patient's insufficiency progresses. Cough can also be a consequence of the disease, and a consequence of the side effects of Conkor. So listen to your doctor, and evaluate the results will be at least after a couple of weeks of treatment.
Guests
Irina
I accept Concor 1,5 years in a dosage of 2,5 mg in the morning.Last time the pressure began to jump both in the big party (150/100), and in the smaller (97/60). Prior to receiving Concor, rapid heartbeats were observed at rest. With the beginning of the reception they left. But the pulse is usually low, 55-46 beats / min.
Guests
Konstantin is 46 years old.
Pressure was 160 \ 100, the doctor appointed a concor, after taking in the morning the upper dropped to 135, and the bottom one is 100 and higher. On a morning pre-trip medical examination, I am sometimes not allowed. In the evening, the pressure is 130 \ 94. Pulse is 60-70. That is, from the lower pressure, concor is not helping. I tried a bunch of pills, I do not know what to do. Can, what will advise?
Administrators
admin
Konstantin is 46 years old., Concor - beta adrenoblocker and primarily affects the heart rate or heart rate and to a lesser extent lowers blood pressure, so the purpose of this drug to adjust blood pressure is not entirely correct, if there is no concomitant tachycardia (an increase in heart rate or heart rate). Depending on the indications and contraindications in a particular patient, it is preferable to prescribe ACE inhibitors (Enalapril, Lysinopril and many other drugs) to lower blood pressure.calcium channel blockers (Nifedipine, Amlodipine), angiotensin 2 receptor antagonists (Lozartan, Telmisartan and others). I advise you to see a doctor for diagnosis and appointment appropriate to the current state of therapy.
Guests
Konstantin 46 years old
Thanks for the detailed answer. Now I understand everything, complex therapy is indispensable. You need to pick up the old recipe. There everything is there. I ignored the recipe, since the side effects were annoying.
Guests
Руслан, 29 years old
This is some kind of kapets! He took Cordaron for a week, but later the doctor decided to spare the thyroid gland and, having lowered the daily dose of Cordarone, added Concor Cori - 1 tab. 2.5mg once a day. On the third day there were red rashes on the hands, on the fourth - I sprinkled everything, as with a chicken pox, everything itches. Thank God, my face and hands are clean, so I can go to work. The trusted doctor from the insurance advised to stop taking everything and drink activated carbon, but does not work. Tomorrow I go to argue with a doctor and think of something. One pleases, for two weeks not one extrasystole has not felt.
Guests
Larissa Dmitrievna
In October, the pressure jumped to 200/100 (and always was 120/80). I am 65 years old. The doctor appointed Concor 2.5 mg and Prestarium 5.0. I drink two months. Only today I read side effects. The muscles began to ache. Weakness in the legs. I can not climb three steps. Only with the help of hands. Tortigated at night. I drink at night 2 tablets. magnerota - the effect is weak - all the same cramps in the muscles. On Saturday I go to the cardiologist - or to cancel a preparation, or to replace. But I think that one prestarium is enough. The pressure is 110/75, the pulse is 65 - 70.
Guests
Small
Assigned concor and motherwort, pressure 150 per 100. Is it worth it to drink? I bought and I think.
Administrators
admin
Small, Pressure increased. Tincture of motherwort has a weak sedative effect. The choice of medicine should be asked by your doctor and follow his recommendations.
Guests
Galina
I drink one year. There was a tachycardia. Last time there was an allergy. And very strong. My eyes itch. Hands are burning.The larynx seems to be squeezing. And the sternum hurts. Inner trembling. Could this be from the Concor? Or is the reason for the other?
Administrators
admin
GalinaProbably the reason is different. Allergic reactions from tablets develop immediately, or in a not very distant future, especially from Concor, which must be taken regularly. A year is too long to form a response. In occasion of allergy manifestations indicated in the question, contact an allergist for diagnosis and treatment.
Administrators
admin
Feedback from the site visitor gulff moved to the required section:
Concor must be drunk for life. It is right.
Guests
Tatyana Sh.
I accept Concor from August 2016. I am 47 years old. From time to time pressure jumped, in July there was an attack, the upper one rose to 195. The therapist prescribed Concor. It seems that tolerance is good, but an incomprehensible allergy to the face returned. After reading the reviews, I realized that she returned just after she began to take Concor. Violation of the menstrual cycle is attributed to the approaching menopause.And again: I became like "feel the heart", especially if I lie on my left side. But the pressure is stable 115/70, the heart rate is about 65, which suits me. Now I do not know how to be: continue to drink it, or go to the doctor?
Administrators
admin
Tatyana Sh., Allergy to medicines is bad in any case, it is not known what kind of reaction it can manifest later if taken in spite of its small manifestations. But the heart needs to be examined - ultrasound, ECG, biochemistry with cardiac indicators for a start.

Otherwise, I prefer ACE inhibitors (Enalapril, lisinopril and their commercial counterparts) as first-line drugs to reduce pressure, but blockers, which include Concor, are more preferable with accompanying problems with rhythm (for example, in the presence of tachycardia). So, taking into account the existing problems, the doctor's consultation is shown to you.
Visitors
Gapon Marina
Hello. My brother is 42 years old. After the second jump in the month of pressure to 210, the doctor prescribed Concor 5 mg, Indap 2.5 mg, Enap 2.5 mg twice daily, and asparagus.He said to drink a month, then gradually reduce the dosage and get away from them. Tell me, please, are these drugs not taken for life? And how long will the effect last for a month?
Administrators
admin
Gapon MarinaAt that age, I did not observe patients who managed to get away from the constant intake of antihypertensive drugs. Up to 30 years this is still possible (and very rare), but with regard to your brother, tablets are likely to have to be taken for life. Correct dosages and the number of medications taken during the treatment is possible and permissible. Your brother is given the lowest possible dosages, so in this regard, the appointment is adequate.
Administrators
admin
Site visitor question musche moved to the required section:
Hello. After a hypertensive crisis, I was assigned ravel sr 1.5 and concor 1.25, I take 2 weeks, the pressure is low 90 to 60. Can I take ravel half a tablet, and then gradually eliminate it?
musche, Diuretic drug Ravel is quite permissible to cancel after a short use,It is only necessary to follow at this time for the values ​​of blood pressure and, in case of an increase, to select with the doctor adequate supportive antihypertensive therapy.
Visitors
Gorbushka
Good afternoon! My mom has been drinking concor-cor 2.5 since 2014. The pressure is normal, there are no complaints, but the pulse has dropped to 60 and there were from this ailment, fatigue, weakness, headaches. Mom decided to take it every other day. So he drinks since the summer of 2016. I did not pay attention to the symptom, but now it became stronger and the question arose whether it could not be with the fact that it took a day or even at the reception itself of this drug. Symptoms: pruritis, allergic drying, red swollen spots like a sting of a wasp, pain in the sternum. Blocks the reception of Sedalgina, passes immediately. At the same time when the drug was prescribed the doctor could not take into account that the mother had chronic bronchitis (it is possible that he had already transferred to asthma already) so there was one case, from a cough she lost consciousness, and periodically the whistle can not clear her throat. Here we do not know to which doctor to go for a start on what can happen from Concor Cor, or is it allergic to something, or even an immune disorder.
Administrators
admin
Gorbushka, Your mom should contact the therapist for delivery of a minimum of tests (I would start with ECG, blood biochemistry and X-ray of the lungs, also it is worth checking the respiratory function of the FVD). After this, it will be clear what is the cause of pain in the chest (heart or lungs).

An allergic reaction may well be at the reception of Concor, so for the time of the examinations, I would replace the drug with another and test this hypothesis. If it takes Concor Cor to reduce blood pressure, I would recommend another remedy (for example, from the ACE inhibitors group: Enalapril, Lysinopril and others), although if the age patient is quite likely that there are problems with the rhythm and a blocker has been assigned, the replacement of the medicine should also be made through the attending physician who sees the patient's medical history, it is better if it is a cardiologist.
Guests
Inna
Hello. My son is 29 years old. The son has a prolapse of the heart valve. Every year a commission passes and this year on ultrasound, the cardiologist saw a slight increase in the ventricle from the readings of the previous year. Has sent to the pathologist, have measured pressure 160/97.Quickly wrote out the concor. But something I, somehow do not like such a fast appointment. Without a full survey, I think it can not be appointed? Have also appointed a magneter and eradby 40. Tell me, please, what to do?
Administrators
admin
Inna, From the pressure of your son, Edarby is prescribed. Concor could be used, but if the pulse is OK, I would be careful not to prescribe this medicine to a young man due to a possible negative effect on potency. This point is debatable and the appointment of a beta-blocker, if there is no emergency, can only be after a thorough examination of the state of the heart and a rigorous justification.
Guests
Inna
I am very grateful to you for the answer. Thank you very much!
Guests
Evgeny Nikolaevich
Somewhere a couple of years ago, a doctor prescribed me a concor in place of a losap and a diroton. However after long reception this preparation has very strongly planted to me pulse (to 37-45 impacts), and pressure all the same was high. Therefore, I stopped taking the concourse and went back to the lopaz.By the way, after the failure of the concourse, the pressure jumped to 200. Therefore, "get off" from him should be gradually.
Guests
Anastasia
At you the incomplete instruction, is still konkor 2,5 mg. To me 32 years and to me registered concord 2,5 mg. It helped, of course, well, but a lot of side effects ...
Administrators
admin
Anastasia, It's just a separate dosage form of Concor, which has a prefix Kor and here it contains 2.5 mg of active ingredient. Has brought necessary explanations in the instruction.
Guests
Silvia
Hello. Tell me please. I accept Concor 2.5 on a floor of a tablet in the morning, has mixed a signal of a reminder and has drunk once again in the evening. When can I drink the next dose to enter the desired rhythm of the reception? Thank you.
Administrators
admin
SilviaThe next Concor tablet should be taken as usual in the morning of the next day in which the error occurred. There is no need to make an extra break.Also measure just in case several times the pulse for the development of bradycardia (pulse reduction).
Visitors
igor140
Heard a rumor, concor promotes the development of ischemic disease. Is there any reason to believe?
Administrators
admin
igor140, This is a rumor. About the worsening of symptoms of heart failure (as manifestations of side effects) in a relatively small percentage of patients taking Concor, you can still speak, but to promote the development of IHD this drug can not. At least statistically, this effect was not detected during the use of the drug.
Visitors
Natha Berne
Hello. I take 2 years of concor, 1/4 tablets and allapinin 1 tablet a day because of ventricular extrasystole and tachycardia. I am 48 years old. Periodically there are dizziness and unsteadiness of gait. The annotation says that concor is not taken together with antiarrhythmic drugs of the 1st class. But the cardiologist says to drink them together.Can I take these drugs together in a similar dosage? Thank you.
Administrators
admin
Natha Berne, Yes, there is such, but also in the instructions to Allapinin it is written: "When sinus tachycardia appears against the background of long-term use of the drug shows the use of beta-blockers in low doses." Given the minimum possible dosage of Concor in your case, such a combination can be considered justified.
Visitors
dinamit
For many years (about 10), without any side effects, Concor 2.5 was taken, then increased to 5.0. Over the past year, twice there was a hypertensive crisis, there was a cough, a cardiogram showed a violation of intrapartum conduction. The cardiologist appointed Valz 80 + Carvedilol 25 in the morning and Carvedilol 25 in the evening. I drink 3 months. The heart is much better, there is no cough, but the pressure is often lower (100/65/68), the upper happens and 86. The doctor advises to drink coffee without sugar in such cases and is satisfied with its purpose, and I had weakness, mild dizziness, even diarrhea .I try to correct - to reduce the dose of one drug, then another, the pressure jumps from here. Perhaps, all it was necessary to increase the dose of the usual Concor preparation to 10 mg and all? Is there a combination of Vals + Concor?
Administrators
admin
dinamitTo prescribe drugs to reduce blood pressure and then coffee? I would allow such an option as a one-time mechanism, but not on an ongoing basis, which, as I understood from the question, has a place to be in your case.

Carvedilol has a broader blocking spectrum, but judging from the description in conjunction with the Valz preparation, Concor can also be used in your case. The main antihypertensive agent in your scheme is still Wales, not blockers. I would try, but I would like to know the rationale of the attending physician, there may be some other side effects or vice versa that led him to replace Concor with Carvedilol. Ask him next time about it.
Visitors
dinamit
Thank you very much for your detailed answer. If all doctors had so much time for the patient, how many problems could be solved on the spot. The next appointment is appointed in a year, apparently, not everything is so scary. I'll try WALZ + CONCORN.
Visitors
Natalia 08042015
Hello, dear admin. Consult, please.
A man, 76 years old, hypertension (now up to 190 per 100), angina, aortic stenosis.
In your opinion, is it possible to receive concor-cortex? Causes concern for the following reasons:
-Pulse normal (60-65), if it is still injurious, there may be a poor state of health,
-in side effects on the instructions indicated a possible increase in bilirubin (there are gallstones, we are afraid of another attack of cholecystitis, when it happened, metronidazole was injected into the tuberculosis, nearly perished from its side effects)
- on ekg there is a blockade (anterior branch of the left leg of the bundle Gies), is there any danger that the concor, and so reducing the conductivity of the heart, will worsen it even more?
- because of aortic stenosis drank vasodilators, will not the possible vasoconstrictive effect of the beta blocker be harmful?
The question is not for self-medication. A full-time cardiologist offers one option for concorcor.
Thank you in advance for your reply.
Administrators
admin
Natalia 08042015As a means of preventing attacks of angina pectoris, Corcor Coron is a good remedy, so in the case of this patient it is necessary to evaluate the pros and cons.The disadvantages are many, if you take into account this array of concomitant pathology, then I would choose another medicine, another question that the patient had already taken to combat angina and attacks, is there space for other appointments (since there is no other motivation than the fight against angina pectoris in terms of the appointment of this drug, I do not see, but if I just lower the blood pressure, then I would choose another antihypertensive drug without a blocking property).
Visitors
Natalia 08042015
If it is possible, I would like to know your opinion, the appointment of drugs of which class (in the sense of not blockers) is possible in this case?
Administrators
admin
Natalia 08042015, This is a whole section of cardiology, and rather big. Everything depends on the class, such as angina pectoris (in general, whether it is angina), possible concomitant diseases and conditions. It can be in addition to blockers, calcium channel antagonists (Verapamil, Diltiazem and other agents), nitrates (Nitroglycerin and the like), additional drugs that affect the state of the heart and blood vessels (pressure, high cholesterol, weight and hormone control) .Angina pectoris is not a disease, it is a way of life for older people.
Guests
Denis110282
Drank concor daily for 5 mg, last week reduced the dose to 2.5. There was a feeling of dizziness and mild nausea.
Guests
Mara
I do not understand why the doctor assigned me this medicine - I could not get an explanation from him. The drug, as far as I understand it, is serious enough and it should not be prescribed in a hurry. At me yesterday for the first time in a life pressure has jumped out for 140, today almost norm. Prior to this, there were occasional small races, but quickly passed and it was at least six months ago. The pulse is high, but it's been my whole life. ECG is the norm.
Guests
lads
Good evening. Saw a tenor 50 mg, and then 100 mg for 7-8 years. Last year there was a dry cough, which is not removed in any way. I read that many after the tenorik also suffer with him and went to the doctor. Have appointed or nominated concor 10 mg in the evening and indapamid 2.5 in the morning. I drink a week and every day I have a pressure of 150 -160, a pulse above 60 does not rise.Again, the cough has tortured and sneezed 5-6 times in a row, behind the sternum pulls. I do not know what to do. The doctor says that you need to get used to it and the pressure stabilizes. Now, the pressure is 167 for 93 pulses.
Administrators
admin
Site visitor question m1298 moved to the required section:
To me 38. Having accepted Concor Cor 2.5mg one tablet in the morning all the day noticeably felt better, the pulse is normal, pressure too. My previous condition: the pressure during the day varied min 122/78 maximum 150/95. And the worst thing is that the heart could not calm down, lying at least 85-90, if you suddenly jump up it can jump to 130 beats / min, then 115 standing while walking to work at a normal step of 120ud / min. A year ago I was engaged in cardio performing walking at the pulse of 120-130 exercise performed with a pulse-meter for 40-60min was practiced 3 times a week. Within 5 years. My condition at that time was a pulse lying 60-70 sitting 70-80, standing 80-90. For the pulse to rise to 120 bpm, I almost had to run. In the autumn, my hernia of the lumbar spine became very painful, I hardly moved, training had to be postponed, then my heart began to hurt painfully on my left side.I have a very big desire to go back to training sensibly, I'd like to do push-up from the floor before and turn-up. Tell me please, I will not set records, can I eventually return to training? And at what maximum pulse can now work? Or am I now disabled permanently.
m1298Begin not with the reception of Concor, but with the diagnosis, for this, give the minimum set of tests to identify possible cardiac pathology: ultrasound of the heart and kidneys, a biochemical blood test with cardiac parameters, write for a week as the pulse changes (if there is an automatic pulse meter, so even better) and consult a cardiologist. Perhaps, after correcting the current indices of drugs, you can return to the training rhythm, it can be less intense, but it's better than without movement.
Guests
Galina
The drug is good, as prescribed by the doctor I accept it from 2014. I am now 70 years old. Increased pressure began after 50 years, I believe that this was also related to the move to the highland region of Yakutia. From medicines I accept konkor 2,5 in the morning and for the night cardiomagnet.Of the side effects sometimes muscle spasms are observed, perhaps it is for other reasons. Palpitation is 60-64, but the pressure sometimes rises 176-92. Most importantly, what worries me, I do not feel any pressure increase at all. I feel fine. Just measure it for order. Thank you for your answers, I read them all.
Visitors
Nikodim
Hello. The instructions say that it is necessary to cancel the reception of Concor for 2 weeks if it does not fit. I take 1.25 mg once a day. Concor Cor, it's half a tablet, it's less likely to break it. How correctly to reduce a dose of reception in that case? Thank you.
Administrators
admin
NikodimSuch a dosage can be canceled at the same time, there should not be any side effects (except the return of the symptoms of the underlying disease, if no substitution treatment is prescribed). This item concerns high dosages of the Concor Cor preparation, for example, with 5 mg, go stepwise to 2.5 mg or with 10 mg stepwise switch to 5 mg, then to 2.5 mg and then later to cancel. By the way, Concor Cor 2.5 mg is the minimum dosage, and the tablets are covered with a film membrane, so it is not necessary to divide them in half.
Visitors
Nikodim
Doctor, thank you for your advice. As I understand from the description of the tests, the reception of Concor will affect the indications of the analysis of the aldosterone-renin ratio. Tell me, when and how to cancel Concor (I accept Concor Cor on 1/2 tablets) before giving the analysis, so as not to suffer health problems (heart rate jumps without Concor)? Thank you.
Administrators
admin
Nikodim, No special regimens and / or abolition of beta-blockers and Concor Cora in particular before the delivery of tests is required. Hand over against the background of taking the drug, only the doctor analyzing the indices should know what is being taken at the time of delivery of the medication (sometimes in commercial centers when passing tests, this information is entered in the order form for the analysis).
Guests
Prokhorova Alla Gennadievna
I drank this concor cor 3 years in a row. The young woman prescribed the doctor, because she went up to the floor in the clinic, entered the office, did not catch her breath, and she measured her pulse along with the pressure. Has there and then registered. I took a sip of the year, I come to her, I ask when I stop taking it, and she's life to me. Okay, I was fine with him, until I scrubbed my legs all the way up.I canceled myself sharply. Here 2 years I do not accept, and my legs are still knee-length combed I can not cure. She still did not warn that this Concor with alcohol can not be prevented, and I regularly washed it with a pint from utretsa.
Guests
Olga
The doctor prescribed Konkor, but after the first drink I started to press in my chest. I began to gasp, I thought I just missed the air, opened the window, the air went, but it got worse. Begin to put pressure on my throat, I did not understand anything, went swelling. I've never had any allergies in my life.
Guests
Olga
Dear doctor, please tell me, can I take Concor Cor following a day? At reception every day even 12.5 mg of the CARDIAC CONTRACTIONS RATE FREQUENTLY sometimes up to 49, but absolutely without this preparation I can not do, at reception in day like it's OK. Am I doing the right thing? Thank you for your reply.
Administrators
admin
OlgaYou need to adjust the dosage or try another beta-blocker. Because with the reception of Concor Cor in a day you will have a non-linear concentration of the drug in the blood, that is, there will be peaks that can harm the heart and blood vessels.It is necessary to adjust the dosage. About 12.5 mg is probably wrong, because the minimum dosage of Concor Kor tablets is 2.5 mg and it can be divided up to 1.25 mg in half, if this is done in your case, then a replacement for another drug is indicated: bisoprolol, Atenolol and their commercial counterparts. Concor leave for the worst of times, it helps you, just too strong.
Visitors
Natalia 08042015
Tell me, please, whether concor is compatible with trental (pentoxifylline), will not it hinder each other? The question is not for self-medication. There are appointments to the father from two different doctors (cardiologist and neurologist). If possible, the same for the cordon (nicorandil) - is it compatible with pentoxifylline? And then there is nowhere to ask about the cordon (a good tool, we would give him feedback if there is a page).
Administrators
admin
Natalia 08042015, All three drugs can be used in one treatment regimen. According to the instructions, there should not be any additional negative side effects when they are used together.

Rules for publishing reviews and visitor questions