Ketoprofen - instructions for use, analogs, testimonials and release forms (tablets 100 mg and 150 mg, gel or ointment 2.5% and 5% Vramed, injections in ampoules for injections) drugs for the treatment of joint pain and bruises in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Ketoprofen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ketoprofen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ketoprofen in the presence of existing structural analogs. Use for the treatment of joint pain with gout, arthritis and bruises in adults, children, as well as during pregnancy and lactation.
Ketoprofen - is a non-steroidal anti-inflammatory drug, a derivative of propionic acid. Has analgesic and antipyretic effect. Severity of anti-inflammatory effect is insignificant. Due to inhibition of cyclooxygenases 1 and 2 and, in part, lipoxygenase, ketoprofen inhibits the synthesis of prostaglandins and bradykinin, stabilizes the lysosomal membranes. Ketoprofen does not adversely affect the condition of the articular cartilage.
Composition
Ketoprofen + auxiliary substances.
Pharmacokinetics
With external application, it is absorbed extremely slowly and practically does not accumulate in the body. Bioavailability of ketoprofen is about 5%. Binding to blood plasma proteins (mainly with albumin) is 99%. Metabolized by conjugation with glucuronic acid. Active metabolites are not formed. It is excreted mainly by the kidneys in the form of metabolites.
Indications
Inflammatory and degenerative diseases of the musculoskeletal system:
- rheumatoid arthritis;
- seronegative arthritis: ankylosing spondylitis - Bechterew's disease, psoriatic arthritis, reactive arthritis (Reiter's syndrome);
- gout, pseudogout;
- osteoarthritis;
Pain syndrome:
- tendonitis, bursitis, myalgia, neuralgia, sciatica;
- headache and toothache;
- post-traumatic and postoperative pain syndrome;
- pain syndrome in cancer;
- algodismenorea.
Uncomplicated injuries, in particular sports, dislocations, sprains or rupture of ligaments and tendons, bruises, post-traumatic pains.
In the combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis).
Forms of release
Gel for external use 2.5% and 5% (sometimes mistakenly called ointment).
Tablets of 100 mg and 150 mg.
Solution for infusion and intramuscular injection (injections in ampoules for injection).
Other dosage forms, be it a cream or a candle, do not exist for this trade name.
Instructions for use and how to use them
Gel
Outwardly.
Adults and children from the age of 12 are given a small amount of gel (3-5 cm) 2-3 times a day with a thin layer, followed by a long and careful rubbing into the inflamed or painful areas of the body.
Children from 6 to 12 years are given no more than 1-2 cm of gel, not more than 2 times a day.The duration of the course of treatment should not exceed 14 days without consulting a doctor.
Can be used in phonophoresis.
Pills
Dosage is set individually, taking into account the severity of the course of the disease. For oral administration for adults, the initial daily dose is 300 mg in 2-3 divided doses. For maintenance treatment, the dose depends on the dosage form used. To treat acute conditions or arrest the exacerbation of a chronic process, 100 mg is administered as a single intramuscular injection.
The maximum dose for ingestion is 300 mg per day.
Ampoules
Intramuscularly in the form of infusions, intramuscularly.
A minimum effective dose should be used with the minimum possible short course.
In / in the infusion of ketoprofen should be carried out only in a hospital.
For short-term intravenous infusions, 100-200 mg (1-2 ampoules) of ketoprofen is dissolved in 100 ml of a 0.9% solution of sodium chloride (physiological solution) and injected for 0.5-1 h; it is possible to re-introduce after 8 hours. For continuous intravenous infusions, 100-200 mg (1-2 ampoules) of ketoprofen is dissolved in 500 ml of the infusion solution (saline solution, Ringer's solution, glucose solution) and injected for 8 hours; After 8 h infusion can be repeated.
Ketoprofen can be used in combination with central action analgesics. For combined use, ketoprofen is mixed with morphine and dissolved in physiological saline or Ringer's solution and injected every 8 hours.
Because of the photosensitivity, the vials with the infusion solution of ketoprofen should be stored wrapped in dark paper or foil. In the form of IM injections of 100 mg (1 ampoule) 1-2 times a day. The daily dose should not exceed 200 mg. Injections should be done deeply. Treatment should not exceed 2 days. If necessary, the continuation of therapy goes to taking oral forms.
Side effect
- skin reactions (itching, urticaria);
- rhinitis;
- dyspnea;
- bronchospasm;
- angioedema;
- anaphylactoid reactions;
- dyspepsia (nausea, diarrhea or constipation, flatulence, vomiting, decreased or increased appetite);
- abdominal pain;
- stomatitis;
- dry mouth;
- ulceration of the mucosa of the gastrointestinal tract;
- exacerbation of Crohn's disease;
- gastrointestinal bleeding;
- headache;
- dizziness;
- drowsiness;
- fatigue;
- nervousness;
- nightmarish dreams;
- migraine;
- peripheral polyneuropathy;
- hallucinations;
- disorientation and speech disorder;
- noise in ears;
- change in taste;
- blurred vision;
- conjunctivitis;
- tachycardia;
- arterial hypertension;
- peripheral edema;
- impaired renal function;
- interstitial nephritis;
- hematuria;
- formation of infiltrate, abscess, necrosis of adipose tissue at the site of injection;
- hemoptysis;
- menometrorrhagia;
- agranulocytosis, anemia, thrombocytopenia, purpura.
Contraindications
- hypersensitivity to the active substance or ancillary components;
- complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses, and intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (including in history);
- erosive and ulcerative changes in the gastric mucosa or duodenum, active gastrointestinal bleeding, cerebrovascular or other bleeding;
- inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the phase of exacerbation;
- hemophilia and other bleeding disorders;
- Decompensated heart failure;
- liver failure;
- expressed renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease,confirmed hyperkalemia;
- period after aortocoronary shunting;
- pregnancy, lactation;
- children age up to 18 years - for injections, up to 6 years - for gel, up to 15 years - for tablets.
Application in pregnancy and lactation
Contraindicated in pregnancy and lactation.
Application in elderly patients
Use with caution in old age.
Use in children
Contraindicated in childhood and adolescence under 18 years (injection form). Up to 6 years (for gel). Up to 15 years (for tablets).
special instructions
During treatment, it is necessary to monitor the picture of peripheral blood and the functional state of the liver and kidneys. If there are signs of liver damage (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, darkening of urine, increased level of "liver" transaminases), stop taking the drug and consult a doctor. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.
Reception of ketoprofen can mask signs of an infectious disease.
Do not use ketoprofen at the same time as other non-steroidal anti-inflammatory drugs (NSAIDs).
Ketoprofen can alter the properties of platelets, but does not replace the preventive effect of Acetylsalicylic acid in cardiovascular diseases.
The use of ketoprofen can adversely affect female fertility and is not recommended for women planning a pregnancy. After 2 weeks of using the drug, it is necessary to monitor the indicators of liver function ("transaminase").
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Drug Interactions
Ketoprofen can weaken the action of diuretics and antihypertensives and increase the effect of oral hypoglycemic and some anticonvulsants (phenytoin).
Joint use with other NSAIDs, glucocorticosteroids, ethanol (alcohol), corticotropin can lead to the formation of ulcers and the development of gastrointestinal bleeding, an increased risk of kidney dysfunction.
Simultaneous administration with oral anticoagulants, heparin, thrombolytic agents, antiaggregants increases the risk of bleeding.Increases hypoglycemic action of insulin and oral hypoglycemic drugs (dose recalculation is necessary). Increases the concentration in the plasma of cardiac glycosides, blockers of slow calcium channels, lithium preparations, cyclosporine, methotrexate. To avoid sediment, ketoprofen and Tramadol should not be mixed in a single vial.
Analogues of the drug Ketoprofen
Structural analogs for the active substance:
- Arketal Rompharm;
- Arthrosylen;
- Artrum;
- Bystrumgel;
- Bystrumcaps;
- Valusal;
- Ketonal;
- Ketonal Duo;
- Ketonal uno;
- Ketoprofen Vramed;
- Ketoprofen MB;
- Ketoprofen Organic;
- Ketoprofen Verte;
- Ketoprofen Eskom;
- Ketosphere;
- OCI;
- Oruvel;
- Profenide;
- Fastum gel;
- Febrofide;
- Flamax;
- Flamax forte;
- Fleksen.
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