Papaverin - instructions for use, reviews, analogs and formulations (40 mg tablets, 20 mg suppositories, injections (injections)) for the treatment of spasms in adults, children and pregnancy

In this article, you can read the instructions for using the drug Papaverine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Papaverine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Papaverin analogues in the presence of existing structural analogues. Use to treat spasms in adults, children, as well as during pregnancy and lactation.

Papaverine - Myotropic antispasmodic.Reduces the tone of smooth muscles of internal organs (GIT, respiratory, urinary, genital system) and blood vessels. It causes an enlargement of the arteries, promotes an increase in blood flow, incl. cerebral. Has hypotensive effect.

In high doses reduces the excitability of the heart muscle and slows intracardiac conduction.

When used in average therapeutic doses, the effect on the central nervous system is poorly expressed.

Pharmacokinetics

Bioavailability is 54%. Well distributed in the body, it penetrates through the histohematological barriers. Metabolised in the liver. It is excreted by the kidneys in the form of metabolites. Completely removed from the blood during dialysis.

Indications

• spasms of smooth muscles of the abdominal cavity organs, bronchi, peripheral vessels, cerebral vessels, kidneys;
• angina pectoris (as part of combination therapy).

As an aid for premedication.

Forms of release

Tablets of 40 mg.

Candles for rectal administration 40 mg.

Solution for injections (injections in ampoules) 20 mg / ml.

Instructions for use and dosage

Inside - 40-60 mg 3-5 times a day. Rectal - 20-40 mg 2-3 times a day.

With intramuscular,subcutaneous or intravenous administration, a single dose for adults is 10-20 mg; the interval between administrations is not less than 4 hours. For elderly patients, the initial single dose is not more than 10 mg. For children aged 1 to 12 years, the maximum single dose is 200-300 mg / kg.

Side effect

• nausea;
• constipation;
• drowsiness;
• increased sweating;
• arterial hypotension;
• development of AV blockade, cardiac arrhythmias (with rapid administration).

Contraindications

• AV blockade;
• glaucoma;
• severe hepatic impairment;
• advanced age (risk of hyperthermia);
• children up to 6 months;
• hypersensitivity to papaverine.

Application in pregnancy and lactation

During pregnancy and lactation (breastfeeding), the safety and effectiveness of papaverine is not established.

special instructions

Use with caution in conditions after traumatic brain injury, with chronic renal failure, with adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, and shock states.

Intravenous should be administered slowly and under the supervision of a doctor.

During the treatment should be excluded from drinking alcohol.

Drug Interactions

With simultaneous use with anticholinergics, anticholinergic effects may be enhanced.

It is believed that with simultaneous use with alprostadil for intracavernous administration, there is a risk of developing priapism.

There are reports of a decrease in the effectiveness of levodopa when it is used simultaneously.

Reduces the hypotensive effect of methyldopa.

Analogues of the drug Papaverin

Structural analogs for the active substance:

• Papaverine is a bouffant;
• Papaverine hydrochloride;
• Papaverine hydrochloride MS;
• Papaverine hydrochloride injection 2%;
• Papaverine hydrochloride tablets for children 0.01 g;
• Candles with papaverine hydrochloride 0.02.

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