Cerepro - instructions for use, analogs, reviews and release forms (capsules or tablets 400 mg, injections in ampoules for injection 4 ml) drugs for the treatment of cerebral circulation, attention in adults, children and pregnancy
In this article, you can read the instructions for using the drug Cerepro. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Cerepro in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cerepro in the presence of existing structural analogues.Use for the treatment of cerebral circulation disorders, concentration of attention, memory in adults, children, as well as during pregnancy and lactation.
Cerepro - holinomimetik central action, which contains 40.5% of metabolically protected choline (metabolic protection contributes to the release of choline in the brain). Upon ingestion, it is cleaved under the action of enzymes on choline and glycerophosphate: choline participates in the biosynthesis of acetylcholine, one of the main neurotransmitter mediators; glycerophosphate is a precursor of phospholipids (phosphatidylcholine) neuronal membrane. The drug provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation; increases the linear velocity of blood flow on the side of traumatic brain injury, contributes to the normalization of spatiotemporal characteristics of spontaneous bioelectrical activity of the brain; has a positive effect on the cognitive and behavioral responses of patients with cerebral vascular diseases.
The drug improves brain function, affecting the pathogenetic factors of the involutionary psychoorganic syndrome, changes the phospholipid composition of neuronal membranes and reduces cholinergic activity. Dosolependently stimulates the release of acetylcholine, participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission, plasticity of neuronal membranes, receptor function.
Composition
Choline alfoscerate (glycerylphosphoryl choline hydrate) + excipients.
Pharmacokinetics
After ingestion, absorption is 88%. Easily penetrates the blood-brain barrier (BBB) (with oral intake, the concentration in the brain reaches 45% of the level in the blood plasma). In the organism of choline, alphoscerate under the action of enzymes is biotransformed to choline and glycerophosphate (providing pharmacological effects of the drug). 85% is excreted by light in the form of carbon dioxide; The remaining part (15%) is excreted in urine and feces.
Indications
- acute and recovery periods of severe craniocerebral trauma (including in cases of impaired consciousness, coma);
- disorders of cerebral circulation according to the ischemic type (acute and recovery period) and hemorrhagic type (recovery period), with focal hemispheric symptoms or symptoms of brain stem damage;
- psychoorganic syndrome on the background of degenerative and involuntary changes in the brain and the consequences of cerebrovascular insufficiency;
- cognitive disorders (impaired mental function, memory, confusion, disorientation, decreased motivation, initiative and ability to concentrate), incl. with dementia and encephalopathy;
- senile pseudomelanchia, changes in the emotional and behavioral sphere: emotional lability, increased irritability, decreased interest.
Forms of release
Capsules 400 mg (sometimes mistakenly called pills).
Solution for intravenous and intramuscular injection in ampoules of 4 ml (injections).
Instructions for use and dosing regimen
Capsules
In acute conditions, the drug is given in / m or / in (slowly) in a daily dose of 1 g (1 ampoule) for 10-15 days, then switch to oral intake of the drug in a daily dose of 1.2 g (800 mg (2 capsules) morning and 400 mg (1 capsule) during the day) for 6 months.
In chronic conditions, the drug is administered orally 400 mg (1 capsule) 3 times a day. The duration of therapy is 3-6 months.
Capsules are recommended to be taken before meals.
Ampoules
The drug is administered intramuscularly at a dose of 1 g (1 ampoule) per day or intravenously (slowly) at a dose of 1 g to 3 g per day.
With intravenous administration, the contents of 1 ampoule (4 ml) are diluted in 50 ml of physiological solution, the infusion rate is 60-80 drops / min.
Duration of treatment is 10-15 days, but if necessary, the treatment can be continued until the appearance of positive dynamics and the ability to switch to taking capsules.
Side effect
- nausea (as a consequence of dopaminergic activation);
- allergic reactions.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy and lactation (breastfeeding).
In experimental studies, there was no mutagenic and teratogenic effect of the drug, as well as an effect on reproductive functions.
Use in children
With caution should be used in children and adolescents under 18 years (due to the lack of data on the effectiveness and safety of the drug)
special instructions
If there is nausea after taking the drug should reduce the dose.
Impact on the ability to drive vehicles and manage mechanisms
Cerepro does not affect the speed of psychomotor reactions.
Drug Interactions
The drug interaction of Cerepro is not established.
Analogues of the drug Cerepro
Structural analogs for the active substance:
- Glaser;
- Gliatilin;
- Glycerylphosphorylcholine hydrate;
- Delecite;
- Noochlin Rompharm;
- Phosal;
- Choline alphoscerate;
- Holilitil;
- Cereton.
Analogues for the pharmacological group (nootropics):
- Amylonosar;
- Aminalon;
- Vinpotropil;
- Gamalon;
- Ginkyo;
- Gliatilin;
- Glycine;
- Gopantam;
- Idebenon;
- Intelland;
- Cortexin;
- Cortexin for children;
- Lucetsam;
- Mexipridol;
- Mexiprim;
- Minisem;
- Noben;
- Hoenopt;
- Nootropil;
- Noocetam;
- Omaron;
- Pantogam;
- Pantokaltsin;
- Pikamilon;
- Piraben;
- Piracesine;
- Piracetam;
- Pyriditol;
- Semax;
- Stamine;
- Tenoten;
- Tenoten for children;
- Thiocetam;
- Fezam;
- Fenibut;
- Phenotropil;
- Cebrilysin;
- Ceraxon;
- Cerebrosolate;
- Cerebrolysin;
- Cereton;
- Energol;
- Encephabol;
- The escotrope.
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