Neovir - instructions for use, analogs, reviews and release forms (tablets of 125 mg, injections in ampoules for injection in a solution №5) preparation for the treatment of herpes, hepatitis, HIV and CMV in adults, children and pregnant

In this article, you can read the instructions for using the drug Neovir. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of neovir in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neovir in the presence of existing structural analogs. Use for the treatment of herpes, hepatitis, HIV and cytomegalovirus in adults, children, as well as during pregnancy and lactation.

Neovir - immunostimulating drug.Has antiviral activity against DNA and RNA genomic viruses. Has a pronounced anti-chlamydial effect. The activity of the drug is related to its ability to induce the formation in the body of high titers of endogenous interferons, especially Interferon alpha.

Intramuscular administration of Neovir in a dose of 250 mg according to the detected serum concentrations of interferon is equivalent to the administration of 6-9 million IU of recombinant interferon alfa.

Neovir activates bone marrow stem cells, T-lymphocytes and macrophages. It shows immunomodulating activity, normalizing the balance between subpopulations of T-helper and T-suppressor cells. In a number of diseases, neovir is able to reduce the production of tumor necrosis factor (HIV infection, herpes) in the body and activate natural killer cells (for tumor diseases). Significantly increases the activity of polymorphonuclear leukocytes.

In HIV infection, neovir has an immunomodulating effect: it increases the absorption activity of blood serum, increases the ability of leukocytes to synthesize interferon alfa, stimulates the formation of active forms of oxygen by phagocytes.

Peak activity of interferons in the blood and tissues is observed a few hours after the introduction of neovir and persists for 16-20 hours.

Composition

Oxodihydroacridinylacetate sodium (kridanimod) + auxiliary substances.

Pharmacokinetics

With intramuscular injection, the bioavailability of neovir is more than 90%. After 5 hours, only insignificant concentrations of the active substance are detected, and after 6 hours the drug is not detected in the blood plasma. After 15-30 min after Neovir administration, serum interferon titers start to increase in the plasma. After 24 hours, the concentration of serum interferons remains high enough, and returns to the initial values ​​after 46-48 hours. It is not metabolized. It is excreted by the kidneys unchanged.

Indications

As an immunostimulating agent in combination therapy:

• prevention and treatment of influenza and other acute respiratory diseases (including against the background of immunodeficiency states);
• infections caused by the Herpes simplex virus type 1 and 2 (oral and genital herpes) and the Varicella zoster virus (including those with immune system disorders);
• cytomegalovirus infection in immunocompromised individuals;
• radiation immunodeficiency;
• treatment of HIV infection;
• encephalitis and encephalomyelitis of viral etiology;
• acute and chronic hepatitis B and C;
• urethritis, epididymitis, prostatitis, cervicitis and salpingitis of chlamydial etiology;
• venereal lymphogranuloma;
• oncological diseases;
• multiple sclerosis;
• Candidiasis of the skin and mucous membranes.

Forms of release

Solution for intramuscular injection (injections in ampoules for injection) № 5.

Tablets coated with 125 mg.

There are no other medicinal forms, whether candles or ointments.

Instructions for use and dosing regimen

Ampoules

The solution for injections is administered intramuscularly, a single dose is 250 mg (1 ampoule) or 4-6 mg / kg body weight. If necessary, a single dose of neovir can be increased to 500 mg.

The course of treatment, if there are no specific instructions, consists of 5-7 I / m injections in single doses at an interval of 48 hours. The course dose depends on the clinical picture. The duration of the course is 8-12 days. With prolonged and prophylactic use, the interval between neovir administration is 3-7 days.

In HIV infection, injection solution is used as part of combination therapy. The course of treatment consists of 10 intravenous injections of 250 mg with an interval betweeninjections 48 hours after the course of therapy take a break 2 months. The number of repeat courses is not limited.

Pills

Inside. Single therapeutic dose - 750 mg; if necessary, single dose is increased to 1500 mg. The course of treatment (if there are no specific instructions) - 5-7 tablets taken in single doses with an interval of 48 hours, the course dose depends on the clinical picture. The duration of the course is 8-12 days. For prolonged or prophylactic use, an interval between taking the tablets is 3-7 days.

Side effect

• low-grade fever;
• allergic reactions;
• local rapidly passing soreness at the site of administration of the drug.

Contraindications

• renal failure of severe degree (QC less than 30 ml / min);
• autoimmune diseases;
• pregnancy;
• lactation (breastfeeding);
• childhood;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

Use in children

Contraindicated in childhood.

special instructions

With poor tolerance or pain in the place of intramuscular injection, it is recommended to inject neovir together with 2 ml of 0.25-0.5% solution of novocaine.

Use with caution in elderly patients.

Drug Interactions

During the time of clinical trials and the use of the drug in clinical practice, incompatibility or potentiation of the drug effect during interaction with other drugs was not recorded.

Information on the physico-chemical incompatibility of Neovir with other drugs is not available.

Analogues of the drug Neovir

The neovir does not have structural analogs for the active substance.

Analogues for the pharmacological group (antiviral drugs):

• Avonex;
• Algiers;
• Alfaron;
• Alfaferon;
• Amizon;
• Amiksin;
• Anaferon;
• Anaferon child;
• Arbidol;
• Arviron;
• Arpetolide;
• Arpefly;
• Acyclovir;
• Valaciclovir;
• Valtrex;
• Virolex;
• Viferon;
• Gevisos;
• Genferon;
• Gerpevir;
• Herpferon;
• Groprinosin;
• Zovirax;
• Isoprinosine;
• Ingavirin;
• Interferon;
• Intron A;
• Inferon;
• Kagocel;
• Lavomax;
• Lokferon;
• Midantan;
• Moliksan;
• Oxolin;
• Oxolin Ointment;
• Orvire;
• Panavir;
• Reaferon;
• Relenza;
• Remantadine;
• Ribavirin;
• Rimantadine;
• Roferon A;
• Tamiflu;
• Tyloron;
• Famvir;
• Famciclovir;
• Fenistil Pencivir;
• Cyclovir;
• Erazaban.

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