Lactulose - instructions for use, reviews, analogs and formulations (syrup 50%) drugs for the treatment of constipation and hepatic encephalopathy in adults, children (including infants and newborns) and during pregnancy. Composition

In this article, you can read the instructions for using the drug Lactulose. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Lactulose in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lactulose in the presence of existing structural analogues. Use to treat constipation and hepatic encephalopathy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Lactulose - laxative.It causes a change in the flora of the colon (an increase in the number of lactobacilli), which leads to an increase in acidity in the lumen of the colon and stimulates its peristalsis. Along with this, the volume increases and the feces softens. As a result, a laxative effect develops, without direct influence on the mucosa and smooth musculature of the large intestine. Under the influence of lactulose, there is also absorption of ammonia in the large intestine, a decrease in the formation of nitrogen-containing toxic substances in its proximal part and, accordingly, their absorption into the vena cava system. Has the ability to inhibit the growth of salmonella in the colon. Does not reduce the absorption of Vitamins and is not addictive. Virtually not absorbed from the intestine.

Composition

Lactulose + excipients.

Pharmacokinetics

After oral administration of lactulose by passage passes into the large intestine, where it is metabolized by bacteria that break down the sugar. As a result, simple organic acids are formed, mainly lactic acid and, to a lesser extent, acetic and formic acid. A small amount of lactulose is absorbed and excreted in the urine unchanged.

Indications

• chronic constipation;
• hepatic encephalopathy;
• salmonellosis (with the exception of generalized forms);
• digestive disorders associated with putrefaction as a result of food poisoning (in newborns, infants and children under 10 years old).

Forms of release

A syrup of 50%.

Instructions for use and how to use them

The dose is set individually. With hepatic encephalopathy, adults are prescribed up to 45-90 ml of syrup in 2-3 doses (up to 90-190 ml per day), according to other indications - 15-45 ml per day. Children older than 1 year - 5-15 ml per day, less than 1 year - 5 ml per day.

Side effect

• at the first admission in therapeutic doses, there may be abdominal pain and flatulence (usually go through 48 hours after the first intake or with subsequent administration);
• nausea, vomiting;
• anorexia;
• an unpleasant aftertaste.

Contraindications

• galactosemia;
• hypersensitivity to lactulose.

Application in pregnancy and lactation

Possible use in pregnancy and lactation (breastfeeding) according to indications.

Use in children

Possible use in children (including infants and newborns) in age-related dosages.

special instructions

Do not use for pain in the abdomen, nausea, vomiting without verification of the diagnosis.

Use with caution in patients with gastro-cardial syndrome. In such cases, treatment should begin with low doses and increase them gradually to avoid the development of flatulence.

Use with caution in patients with diabetes mellitus, especially with inflammatory bowel disease.

With long-term treatment (more than 6 months), the level of potassium, chlorine and carbon dioxide in the blood plasma should be regularly monitored.

If diarrhea occurs, you should stop taking lactulose.

Drug Interactions

At simultaneous application with antibiotics of a wide spectrum of action reduction of therapeutic efficiency of a lactulose is possible.

With the simultaneous use of lactulose, it can disrupt the release of active substances from enteric-soluble drugs with pH-dependent release because it lowers the pH of the intestinal contents.

Analogues of the drug Lactulose

Structural analogs for the active substance:

• Good luck;
• Dufalac;
• Lactulose is crystalline;
• Lactulose Poli;
• Lactulose Stade;
• The Legend;
• Lievoyk;
• Lizalak;
• Normase;
• Portalac;
• Romfalak.

Similar medicines:

Other medicines: