Sibazon - instructions for use, reviews, analogs and forms of release (5 mg tablets, injections in ampoules for injection in a solution of 0.5%) drugs for the treatment of neurosis, epileptic status, motor agitation in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Sibazon. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Sibazone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Sibazon in the presence of existing structural analogs.Use for the treatment of neurosis, epileptic status, motor agitation in adults, children, as well as during pregnancy and lactation.

Sibazon - a tranquilizer, a benzodiazepine derivative. Has anxiolytic, sedative, anticonvulsant, central muscle relaxant effect. The mechanism of action is associated with increased inhibitory effect of GABA in the central nervous system. The miorelaksiruyuschee effect is due also to the inhibition of spinal reflexes. Can cause an anticholinergic effect.

Composition

Diazepam + excipients.

Pharmacokinetics

Suction fast. Binding to plasma proteins is 98%. It penetrates through the placental barrier, into the cerebrospinal fluid, and is excreted in breast milk. Metabolised in the liver. It is excreted by the kidneys - 70%.

Indications

• neuroses;
• borderline states with the phenomena of tension, anxiety, anxiety, fear;
• sleep disorders;
• motor excitation of various etiologies in neurology and psychiatry;
• abstinence syndrome in chronic alcoholism;
• spastic conditions associated with damage to the brain or spinal cord;
• myositis, bursitis, arthritis accompanied by tension of skeletal muscles;
• status epilepticus;
• premedication before anesthesia;
• as a component of combined anesthesia;
• facilitating labor activity;
• premature delivery;
• premature placental abruption;
• tetanus.

Forms of release

Tablets 5 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection) 0,5%.

Instructions for use and dosage

The dose is calculated individually, depending on the patient's condition, clinical picture of the disease, sensitivity to the drug.

When administered orally, the average single dose for adults is 5-15 mg. In some cases, with expressed excitement, fear, anxiety, a single dose is increased to 20 mg. The daily dose is usually 15-45 mg, the maximum daily dose is 60 mg. The daily dose of the drug is divided into 2-3 doses.

Average recommended doses for different conditions

As an anxiolytic - 5-10 mg 2-4 times a day.

With alcoholic withdrawal syndrome - 10 mg 3-4 times a day in the first 24 hours, followed by a decrease to 5 mg 3-4 times a day.

Older patients and weakened patients receive the drug at lower doses, which are 1/2 or 2/3 of the average.

Neurology: spastic conditions of central origin in degenerative neurological diseases - 5-10 mg 2-3 times a day.

Clinic of internal diseases: 5 mg 2-3 times a day, if necessary and taking into account the tolerance - up to 10 mg 4 times a day.

Menopausal and menstrual disorders: 5 mg 2-3 times a day.

Anaesthesiology, surgery: premedication - on the eve of surgery, in the evening - 10-20 mg.

Pediatrics: prescribed with a gradual increase in dose (starting with low doses and slowly increasing them to the optimal dose, well tolerated by the patient), a daily dose (can be divided into 2-3 doses, with the main, largest dose being taken in the evening) for children from 7 years and older - 5 mg. The maximum daily dose is 10 mg.

Side effect

• drowsiness;
• dizziness;
• muscle weakness;
• confusion of consciousness;
• depression;
• visual impairment;
• headache;
• tremor;
• sense of anxiety;
• sleep disorders;
• hallucinations;
• hiccough;
• memory impairment;
• constipation;
• nausea;
• dry mouth;
• salivation;
• increased or decreased libido;
• urinary incontinence;
• with parenteral application, some decrease in blood pressure is possible;
• skin rash.

Contraindications

• severe myasthenia gravis;
• severe chronic hypercapnia;
• indication in the history of alcohol or drug dependence (except acute withdrawal);
• increased sensitivity to diazepam and other benzodiazepines.

Application in pregnancy and lactation

Do not use Sibazon in the first trimester of pregnancy, except in cases of extreme necessity. It should be borne in mind that with the use of Diazepam in pregnancy, a significant change in the fetal heart rate is possible.

When used in obstetrics in doses recommended for the relief of labor, in newborns, more often in premature babies, temporary hypotension, hypothermia, and respiratory failure are possible.

With regular admission during lactation, breastfeeding should be discontinued.

Use in children

It is necessary to avoid the use of Sibazone in newborns, since they have not yet fully formed the enzyme system involved in the metabolism of diazepam.

special instructions

With extreme caution apply in patients with cardiac and respiratory insufficiency, organic changes in the brain (in such cases, it is recommended to avoid parenteral diazepam administration), with angle-closure glaucoma and predisposition to it, with myasthenia gravis.

Special care is required in the use of Sibazone, especially at the beginning of treatment, in patients who have received long-term antihypertensive drugs of central action, beta-adrenoblockers, anticoagulants, cardiac glycosides.

If you cancel therapy, the dose should be reduced gradually. With sudden withdrawal of diazepam after prolonged use, anxiety, agitation, tremors, convulsions are possible.

Diazepam should be abolished with the development of paradoxical reactions (acute arousal, anxiety, sleep disturbances and hallucinations).

After intramuscular injection of Sibazone, an increase in the activity of CK in the blood plasma is possible (which should be taken into account in the differential diagnosis of myocardial infarction).

Avoid intraarterial administration.

During the treatment period, do not drink alcohol.

Impact on the ability to drive vehicles and manage mechanisms

Sibazon can cause a slowdown in the rate of psychomotor reactions, which should be taken into account by patients involved in potentially hazardous activities.

Drug Interactions

When used simultaneously with drugs that exert a depressant effect on the central nervous system (incl.with neuroleptics, sedatives, hypnotics, opioid analgesics, means for anesthesia), the oppressive effect on the central nervous system, on the respiratory center, expressed arterial hypotension increases.

With simultaneous use with tricyclic antidepressants (including with amitriptyline), it is possible to increase the oppressive effect on the central nervous system, increase the concentration of antidepressants, and increase cholinergic action.

Patients who received long-term antihypertensive drugs of central action, beta-blockers, anticoagulants, cardiac glycosides, degree and mechanisms of drug interaction are unpredictable.

With simultaneous use with muscle relaxants, the effect of muscle relaxants is increased, the risk of apnea increases.

With simultaneous use with oral contraceptives, it is possible to enhance the effects of Sibazone. Increased risk of development of breakthrough bleeding.

With simultaneous use with bupivacaine may increase the concentration of bupivacaine in blood plasma; with Diclofenac - may increase dizziness; with Isoniazid - a reduction in the excretion of diazepam from the body.

Drugs that induce induction of liver enzymes, incl.antiepileptic drugs (carbamazepine, phenytoin), can accelerate the excretion of diazepam.

With simultaneous use with caffeine, the sedative and, perhaps, the anxiolytic effect of diazepam decreases.

With simultaneous application with clozapine, arterial hypotension, respiratory depression, loss of consciousness are possible; with levodopa - suppression of antiparkinsonian action is possible; with lithium carbonate - a case of development of a coma is described; with Metoprolol - reduction of visual acuity, deterioration of psychomotor reactions are possible.

With simultaneous application with paracetamol, a decrease in the excretion of diazepam and its metabolite (desmethyldiazepam) is possible; with Risperidone - cases of ZNS development are described.

With simultaneous use with rifampicin, Sibazone excretion is increased due to a significant increase in its metabolism under the influence of rifampicin.

Theophylline in low doses, distorts the sedative effect of diazepam.

With the simultaneous use in rare cases, diazepam inhibits metabolism and enhances the effect of phenytoin. Phenobarbital and phenytoin can accelerate the metabolism of diazepam.

With simultaneous application of fluvoxamine increases the concentration in the blood plasma and side effects of diazepam.

With simultaneous use with cimetidine, omeprazole, disulfiram, an increase in the intensity and duration of action of diazepam is possible.

With the simultaneous intake of ethanol (alcohol), ethanol-containing drugs, the oppressive effect on the central nervous system (mainly the respiratory center) increases, and a syndrome of pathological intoxication may also occur.

Analogues of the drug Sibazon

Structural analogs for the active substance:

• Apaurin;
• Valium Rosh;
• Diazepabene;
• Diazepam;
• Diazepec;
• Diapam;
• Relanium;
• Relium;
• Seduxen.

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