Tussin - instructions for use, reviews, analogs and forms of release (syrup plus) medications for cough, including dry with colds, flu and ARVI in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Tussin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Tussin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tussin in the presence of existing structural analogs. Use to treat cough, including dry colds, flu and ARVI in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Tussin - mucolytic and expectorant, reduces the viscosity of phlegm, facilitates its removal and promotes the transition of non-productive cough to productive. The duration of action for a single admission is 3.5-4 hours.

Guaifenesin has an expectorant effect due to increased secretion of liquid components of bronchial mucus, depolymerization of acid mucopolysaccharides, increased activity of ciliated epithelium.

Dextromethorphan suppresses excessively intense afferent impulses from the mucous membrane of the respiratory tract, increases the cough threshold, reducing the intensity of dry irritating cough. Dextromethorphan is a D-isomer of levofanol, it is close to codeine by the force of action, but it does not possess analgesic properties, does not inhibit the respiratory center and the activity of the ciliary epithelium. The duration of the antitussive action is 5-6 hours.

Composition

Guaifenesin + excipients (Tussin).

Guaifenesin + Dextromethorphan hydrobromide + excipients (Tussin Plus).

Pharmacokinetics

Guaifenesin is quickly absorbed from the digestive tract (after 25-30 minutes after ingestion). Penetrates into tissues containing acidic mucopolysaccharides.Metabolised in the liver. It is excreted by the lungs (with phlegm) and by the kidneys in the form of inactive metabolites.

Dextromethorphan is rapidly absorbed into the digestive tract and its effect begins to manifest after 15-30 minutes. Dextromethorphan is metabolized, primarily, by liver enzymes, undergoing O-demethylation, N-demethylation and partial binding to glucuronic acid and sulfates. In humans, (+) - 3-hydroxy-r4-methylmorphinan, (+) - 3-hydroxymorphine and traces of the non-metabolized drug can be detected in the urine after oral administration.

Indications

Cough with difficulty in sputum in inflammatory diseases of the upper respiratory tract:

• with acute viral infections and colds;
• with influenza;
• with acute laryngitis, pharyngitis, tracheitis, bronchitis.

Forms of release

Syrup.

There are no other dosage forms, whether it's a pill or a solution.

Instructions for use and dosing regimen

Syrup Tussin

Apply no more than 4-6 single doses during the day. The drug should be used after meals.

Single dose: for children from 2 to 6 years - 1/2 -1 teaspoon (50-100 mg) with an interval of 6-8 hours. Children from 6 to 12 years - 1-2 teaspoons (100-200 mg) 3- 4 times a day.Children from 12 years and adults - 2-4 teaspoons (200-400 mg) 3-4 times a day.

Syrup Tussin Plus

Take inside after eating with a teaspoon or measuring cup.

For adults and children over 12 years - 2 teaspoons every 4 hours.

For children (6-12 years) - 1 teaspoon every 4 hours.

Side effect

• dyspepsia (nausea, vomiting);
• diarrhea;
• exacerbation of peptic ulcer of the stomach and duodenum;
• dizziness;
• headache;
• drowsiness or insomnia;
• increased excitability (especially in children);
• allergic reactions (skin rash, hives, hyperthermia).

Contraindications

• severe organic diseases of the central nervous system;
• peptic ulcer of the stomach and duodenum;
• gastric bleeding (in the anamnesis);
• moist cough with abundant sputum discharge;
• simultaneous administration of drugs containing substances included in the preparation Tussin Plus;
• children under 2 years (Tussin), and up to 6 years (Tussin Plus);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Use with caution in pregnancy and lactation.

Use in children

Tussin Plus is contraindicated for children under 6 years of age, Tussin for children under 2 years.

special instructions

It is recommended to take a sufficient amount of liquid during treatment.

It is possible to stain the urine pink.

The results of the determination of 5-hydroxyindoleacetic acid in urine (with the use of nitrosonaphthol reagent) can be falsely inflated due to the influence of guaifenesin metabolites on color (gwayfenesin should be discontinued 48 hours before urine collection for this test).

Guaifenesin and its metabolites can cause a discolouration in the determination of vanillylmandelic acid in the urine and falsely elevate the test results with it on catechins (taking guaifenesin should be discontinued 48 hours before urine collection for this test).

Tussin Plus is supplied with a dispensing cup with 1 TSP = 1 teaspoon = 5 ml.

Impact on the ability to drive vehicles and manage mechanisms

During the period of treatment, care should be taken when performing work that requires concentration of attention, increased speed of motor and mental reactions, and also to refrain from drinking alcohol.

Drug Interactions

Tussin Plus is compatible with bronchodilators, antimicrobial agents, cardiac glycosides.

Tussin Plus is not prescribed simultaneously with antitussive (including containing codeine) and mucolytic agents.

Incompatible with drugs that inhibit MAO (including furazolidone, procarbazine, selegiline), which can cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial bleeding, drowsiness, nausea, spasms , tremor.

Amiodarone, fluoxetine, quinidine, inhibiting the cytochrome P450 system, can increase the concentration of the drug in the blood.

Tobacco smoke can lead to increased secretion of glands on the background of inhibition of cough reflex.

Analogues of the drug Tussin

Structural analogs for the active substance:

• Coldrex bronchus;
• Sinethos.

Analogues for the pharmacological group (antitussives):

• Alex Plus;
• Bronhitusen Vramed;
• Broncholine sage;
• Broncholitin;
• Bronchoton;
• Bronchocine;
• Glycodine;
• Grippostad Good Night;
• Kodelak;
• Kodelak Broncho;
• Kodelak fito;
• Kodelmikst;
• Codipron;
• Codterpine;
• Co -anol;
• Neo Codion;
• Neo Codion for adults;
• Neo Codion for children;
• Padeviks;
• Paracodamol;
• Rengalin;
• Tedein;
• Terasil D;
• Tercodin;
• Terpinkod;
• Tussin plus;
• Fervex from a dry cough.

Similar medicines:

Other medicines: