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Three Regol - instructions for use, analogs, testimonials and release forms (a set of tablets of 21 and 28 (21 + 7) pieces) of the contraceptive drug for contraception in women, including during pregnancy and lactation. Composition and side

Three Regol - instructions for use, analogs, testimonials and release forms (a set of tablets of 21 and 28 (21 + 7) pieces) of the contraceptive drug for contraception in women, including during pregnancy and lactation. Composition and side

In this article, you can read the instructions for using the drug Three Regol. Comments of visitors of the site - consumers of this contraceptive hormonal medication, as well as opinions of doctors of specialists on the use of Three Regulators in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Three Regola in the presence of existing structural analogues.Use for contraception in women, including during pregnancy and lactation. Composition of the preparation.

 

Three Regol - combined (three-phase) oral contraceptive estrogen-progestational drug. At reception oppresses a pituitary secretion of gonadotropic hormones. The sequential administration of tablets containing different amounts of progestin (levonorgestrel) and estrogen (ethinylestradiol) provides a concentration of these hormones in the blood that are close to their concentrations during the normal menstrual cycle and promotes the secretory transformation of the endometrium.

 

The contraceptive effect is associated with several mechanisms. Under the influence of levonorgestrel comes the blockade of releasing the releasing factors (luteinizing and follicle-stimulating hormones) of the hypothalamus, suppressing the secretion of the gonadotrophic hormones by the pituitary gland, which leads to inhibition of maturation and release of the ovum ready for fertilization. Ethinyl estradiol retains a high viscosity of the cervical mucus (making it difficult for sperm to enter the uterine cavity). Along with the contraceptive effect, the menstrual cycle is normalized, thanks to the replenishment of the level of endogenous hormones with the hormonal components of the Three Regol tablets.In 7-day periods, when there is another break in taking the drug, there is a uterine bleeding.

 

Composition

 

Ethinyl estradiol + levonorgestrel + auxiliary substances.

 

Pharmacokinetics

 

Levonorgestrel

 

Levonorgestrel is rapidly absorbed (less than 4 hours). Levonorgestrel has no effect of "first passage" through the liver. Most of the levonorgestrel in the blood binds to albumin and to the globulin that binds the sex hormones.

 

Ethinylestradiol

 

Ethinyl estradiol is quickly and almost completely absorbed from the digestive tract. Ethinyl estradiol is exposed to the effect of "first passage" through the liver. Metabolism is carried out in the liver and intestines. When ingestion, ethinyl estradiol is released within 12 hours from the blood plasma. Metabolites of ethinyl estradiol: water-soluble derivatives of sulfate or glucuronide conjugation, enter the intestines with bile, where they are disintegrated with intestinal bacteria. 60% of levonorgestrel is excreted by the kidneys, 40% through the intestine, 40% of ethinyl estradiol is excreted by the kidneys and 60% by the intestine.

 

Indications

  • oral contraception.

 

Forms of release

 

The tablets covered with a cover of 21 and 28 (21 + 7) pieces in a package.

 

Instructions for use and reception scheme

 

The drug should be taken orally, at the same time of the day, whenever possible in the evening. Tablets are swallowed whole, without chewing and washing down with a small amount of liquid.

 

For the purpose of contraception in the first cycle, Three Regol is prescribed daily 1 tablet per day for 21 days, starting from the 1st day of the menstrual cycle, then a 7-day break occurs, during which menstrual bleeding occurs. The next package containing 21 coated tablets should be taken on the 8th day after the 7-day break.

 

The drug is taken as long as there is a need for contraception.

 

When switching from another oral contraceptive to taking TriRegol, a similar scheme is used.

 

After abortion, it is recommended to start taking the drug on the same day or the day after the operation.

 

After birth, taking the drug is recommended only to women who do not breast-feed.

 

Reception should be started no earlier than the 1st day of the menstrual cycle. During lactation, the use of the drug is contraindicated.

 

If the woman did not accept the Three Regulators in the prescribed time,should take the missed tablet within the next 12 hours. If after taking the pill 36 hours pass, contraception can not be considered reliable. However, in order to avoid intermenstrual bleeding, it is necessary to continue taking the drug from the package that has already been started, minus the missing tablet (s). At this time it is recommended to additionally apply another, non-hormonal method of contraception (for example, barrier).

 

Side effect

  • nausea, vomiting;
  • headache;
  • engorgement of mammary glands;
  • weight gain;
  • decreased libido;
  • depressed mood;
  • intermenstrual bleeding;
  • swelling of the eyelids;
  • conjunctivitis;
  • impaired vision;
  • discomfort when wearing contact lenses (these phenomena are temporary and disappear after withdrawal without prescribing any therapy);
  • decreased glucose tolerance;
  • increased blood pressure;
  • hepatitis;
  • adenoma of the liver;
  • diseases of the gallbladder (for example, cholelithiasis, cholecystitis);
  • thrombosis and venous thromboembolism;
  • skin rash;
  • hair loss;
  • increased vaginal discharge;
  • candidiasis of the vagina;
  • increased fatigue;
  • diarrhea;
  • generalized itching;
  • cramps of the calf muscles;
  • hearing loss;
  • increased frequency of epileptic seizures;
  • coarsening of the voice.

 

Contraindications

  • severe liver disease;
  • liver tumors;
  • congenital hyperbilirubinemia (syndromes Gilbert, Dubin-Johnson and Rotor);
  • cholelithiasis;
  • cholecystitis;
  • chronic colitis;
  • presence or indication in the history of severe cardiovascular (including decompensated heart diseases) and cerebrovascular changes, thromboembolism and predisposition to them;
  • phlebitis of deep veins of lower extremities;
  • hormone-dependent malignant neoplasms of genital organs and mammary glands (including suspicion of them);
  • family forms of hyperlipidemia;
  • Arterial hypertension with systolic / diastolic BP 160/100 mm Hg and higher;
  • surgical operations, surgical operations on the lower limbs;
  • long-term immobilization;
  • extensive injuries;
  • pancreatitis (including in the anamnesis), accompanied by severe hypertriglyceridemia and hyperlipidemia;
  • jaundice due to the use of drugs containing steroids;
  • severe forms of diabetes mellitus;
  • sickle-cell anemia;
  • chronic hemolytic anemia;
  • vaginal bleeding of unknown etiology;
  • migraine;
  • bladder skidding;
  • otosclerosis with worsening of the course during the preceding pregnancy (s);
  • idiopathic jaundice of pregnant women, severe pruritus of pregnant women, herpes of pregnant women in anamnesis;
  • smoking over the age of 35, age over 40;
  • lactase insufficiency, lactose intolerance, glucose-galactose malabsorption (in the drug form of the drug contains lactose);
  • pregnancy;
  • lactation period;
  • hypersensitivity to any component of the drug.

 

Application in pregnancy and lactation

 

During pregnancy and lactation, the drug Tri Regol is contraindicated.

 

special instructions

 

Before starting the use of the drug, pregnancy should be excluded, general medical and gynecological examination should be carried out (mammary gland examination, cytological analysis of the smear).

 

When taking the drug requires a regular gynecological examination every 6 months.

 

The use of oral contraceptives is allowed no earlier than 6 months after the transferred viral hepatitis and under the condition of normalization of hepatic functions.

 

If there is a sharp pain in the upper abdominal areas, hepatomegaly or signs of intra-abdominal hemorrhage, there may be a suspicion of a liver tumor. In this case, the drug should be discontinued.

 

When acyclic bleeding occurs, it is possible to continue taking Triregol after the elimination of organic pathology by the treating physician.

 

When revealing violations of the liver during the use of the drug should decide whether it is advisable to continue taking the drug Tri Regol.

 

In the case of vomiting or diarrhea, the drug should be continued, with the addition of another, non-hormonal contraceptive method.

 

At least 3 months before the planned pregnancy, the drug should be stopped.

 

Under the influence of oral contraceptives (in connection with the estrogen component), certain laboratory parameters (functional parameters of the liver, kidneys, adrenals, thyroid gland, blood coagulation factors and fibrinolytic factors, levels of lipoproteins and transport proteins) can vary.

 

The drug should be discontinued immediately in the following cases:

  • with a migraine-like or unusually severe headache, with acute worsening of visual acuity, with suspicion of thrombosis or infarct;
  • with a sharp increase in blood pressure, the appearance of jaundice or hepatitis without jaundice, the emergence of generalized pruritus or the increase of epileptic seizures;
  • at approach of pregnancy;
  • 6 weeks before the planned operation, with prolonged immobilization (for example, after injuries).

 

Impact on the ability to drive vehicles and manage mechanisms

 

The intake of the drug does not affect the ability to drive and work with other mechanisms.

 

Drug Interactions

 

With the simultaneous administration of the drug Tri Regol with ampicillin, rifampicin, chloramphenicol, neomycin, polymyxin B, sulfonamides, tetracyclines, dihydroergotamine, tranquilizers, phenylbutazone, because these drugs can weaken the contraceptive effect. Therefore, it is recommended to additionally apply a different, non-hormonal contraceptive method.

 

With the simultaneous administration of the drug Tri Regol with anticoagulants, coumarin or indanedione derivatives, it may be necessary to determine the prothrombin index and change the dose of the anticoagulant.

 

With the simultaneous administration of the drug Tri Regol and tricyclic antidepressants, maprotiline, beta-blockers may increase bioavailability and, therefore, toxicity.

 

With simultaneous administration of the drug Tri Regol and oral hypoglycemic drugs, insulin may need to change their doses.

 

With the simultaneous administration of the drug Tri Regol and bromocriptine, the effectiveness of the latter decreases.

 

With the simultaneous administration of the drug Tri Regol and drugs with a possible hepatotoxic effect, especially dantrolene, the risk of increasing hepatotoxicity increases, especially in women over 35 years of age.

 

Analogues of the drug Three Regol

 

Structural analogs for the active substance:

  • Antotevin;
  • Microinon;
  • Miniziston;
  • Miniziston 20 fems;
  • Ovidon;
  • Oralcon;
  • Rigevidone;
  • Rhevidone 21 + 7;
  • Three Regol 21 + 7;
  • Trigestrel;
  • Trikwilar.

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Reviews (1):
Guests
Enness
Something broke in my hormonal background. First, an unidentified brown daub went out in the wrong timeframes, which should be monthly, then canceled the three regolas, the monthly ones stopped coming at all.I switched to other contraceptives, on which I used to sit.

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