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Tiogamma - instructions for use, reviews, analogs and forms of release (tablets 600 mg, injections in ampoules for injections in droppers) of the drug for the treatment of diabetic and alcoholic polyneuropathy in adults, children and pregnancy. Composition

Tiogamma - instructions for use, reviews, analogs and forms of release (tablets 600 mg, injections in ampoules for injections in droppers) of the drug for the treatment of diabetic and alcoholic polyneuropathy in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Tiogamma. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tiogamma in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tiogamma in the presence of existing structural analogues.Use for the treatment of diabetic and alcoholic polyneuropathy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Tiogamma metabolic drug. Thioktovaya (alpha-lipoic) acid is an endogenous antioxidant (binds free radicals), it is synthesized in the body by oxidative decarboxylation of alpha-keto acids. As a coenzyme mitochondrial multienzyme complexes is involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance.

 

Participates in the regulation of lipid and carbohydrate metabolism, affects the exchange of cholesterol, improves liver function, has a detoxification effect in poisoning with salts of heavy metals and other intoxications. Has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects. Improves trophic neurons.

 

With diabetes, thioctic acid improves endoneural blood flow,increases the content of glutathione to a physiological value, which as a result leads to an improvement in the functional state of peripheral nerve fibers in diabetic polyneuropathy.

 

Composition

 

Thioctic acid + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, Tiogamma is rapidly and almost completely absorbed from the digestive tract. At simultaneous reception with food absorption decreases. Bioavailability - 30-60% due to the effect of "first passage" through the liver. Metabolized in the liver by side chain oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%), in a small amount - in unchanged form.

 

Indications

  • diabetic polyneuropathy;
  • alcoholic polyneuropathy.

 

Forms of release

 

Tablets coated with 600 mg.

 

Solution for infusions (in droppers).

 

Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).

 

Instructions for use and how to use them

 

Pills

 

Assign inside 600 mg (1 tablet) 1 time per day.

 

Tablets are taken on an empty stomach, without chewing, with a small amount of liquid.

 

The duration of the course of treatment is 30-60 days, depending on the severity of the disease.It is possible to repeat the course of treatment 2-3 times a year.

 

Ampoules

 

At the beginning of the course of treatment, the drug is administered intravenously at a dose of 600 mg per day (1 ampoule concentrate for solution for infusion or 1 bottle of solution for infusion) for 2-4 weeks. Then you can continue taking the drug inside at a dose of 600 mg per day.

 

Rules for the preparation and administration of an infusion solution (how to chop Tiogamma)

 

For the preparation of the infusion solution, the contents of 1 ampoule concentrate (contains 600 mg of thioctic acid) are mixed with 50-250 ml of 0.9% sodium chloride solution.

 

Immediately after preparation, the vial with the infusion solution is immediately covered with the attached light-protecting case. thioctic acid is sensitive to light. The infusion solution should be administered immediately after preparation. The maximum storage time of the prepared solution for infusions is no more than 6 hours.

 

When using a ready-made solution for infusions, the vial with the drug is taken out of the box and immediately covered with the attached light-protective case, tk. thioctic acid is sensitive to light. Infusion is produced directly from the vial.

 

Enter slowly, about 1.7 ml / min, for 30 min.

 

Side effect

  • point bleeding in mucous membranes, skin;
  • thrombocytopenia;
  • hemorrhagic rash (purpura);
  • thrombophlebitis;
  • systemic reactions (itching, nausea, discomfort) until the development of anaphylactic shock;
  • hives;
  • change or violation of taste sensations;
  • cramps right up to an epileptic fit;
  • diplopia;
  • eczema;
  • rash;
  • irritation, flushing or swelling (at the injection site);
  • in the case of rapid administration of the drug may increase intracranial pressure (there is a feeling of heaviness in the head), difficulty breathing.

 

Contraindications

  • pregnancy;
  • lactation period (breastfeeding);
  • children's age till 18 years;
  • hypersensitivity to thioctic acid or other components of the drug.

 

Application in pregnancy and lactation

 

The drug Tiogamma is contraindicated in pregnancy and lactation (breastfeeding).

 

Use in children

 

The drug is contraindicated in children and adolescents under the age of 18 years.

 

special instructions

 

Patients with diabetes require constant monitoring of blood glucose concentration, especially at the initial stage of therapy. In some cases, it is necessary to reduce the dose of insulin or an oral hypoglycemic drug in order to avoid the development of hypoglycemia.If symptoms of hypoglycemia occur (dizziness, increased sweating, headache, visual disturbances, nausea), discontinue therapy immediately. In isolated cases with the use of Thiogamma in patients with a lack of glycemic control and in a severe general condition, serious anaphylactic reactions may develop.

 

Drinking alcohol during therapy with Thiogamma reduces the therapeutic effect and is a risk factor that contributes to the development and progression of neuropathy. During treatment with Tiogamma, you should refrain from drinking alcohol.

 

Impact on the ability to drive vehicles and manage mechanisms

 

The use of Thiogamma does not affect the ability to drive a vehicle and work with other mechanisms.

 

Drug Interactions

 

Thioctic acid reduces the effectiveness of Cisplatin while taking it, and also reacts with metal-containing drugs, such as iron and magnesium preparations.

 

Thioctic acid reacts with sugar molecules, forming hardly soluble complexes, for example with a solution of levulose (fructose).

 

Tiogamma enhances the anti-inflammatory effect of glucocorticosteroids (GCS).

 

With the simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may be enhanced.

 

Ethanol (alcohol) and its metabolites weaken the action of thioctic acid.

 

Pharmaceutical interaction

 

The infusion solution of thioctic acid is incompatible with the Dextrose solution, Ringer's solution and with solutions reacting with disulfide and SH-groups.

 

Analogues of the drug Tiogamma

 

Structural analogs for the active substance:

  • Alpha lipoic acid;
  • Berlition 300;
  • Berlition 600;
  • Lipamid tablets;
  • Lipoic acid;
  • Liptiokson;
  • Neurolephone;
  • Octolipen;
  • Thiocacid 600;
  • Tioctacide BV;
  • Thiolept;
  • Thiolipone;
  • Espa Lipon.

Similar medicines:

Other medicines:

Reviews (42):
Can I use Tiogamma for gout? Thiogamma was prescribed for suspected diabetic polyneuropathy. As a result, signs of gout were exacerbated.
Administrators
admin
jhin.cоm1951.24.10, Applying Tiogamma with gout is possible. Probably your case is just a coincidence.Maybe they broke the diet or something. Such a side effect when using Tiogamma is not observed and in contra-indications there is also no gout.
Your opinion about the WTEC, can I apply additionally with Tiogamma?
Administrators
admin
jhin.cоm1951.24.10, I do not use the interstitial stimulation (VTES) in my practice. If medications do not help, then this technique, most likely, will be useless. And if the result is, then the duration of the therapeutic effect will be no more than medicinal relief of pain (an average of 2-3 years for neglected cases).

With Tiogamma, the technique is combined. It can be considered as an additional physiotherapy treatment.
I apply Tiogamma and Neuromultivitis. All the signs of polyneuropathy of the lower limbs (legs like being in leather socks and numb toes). At inspection on ENMG the conclusion has been made: all nerves in norm or rate. Whether there can be attributes of a polyneuropathy are connected with hernias of a backbone L4-L5, L5-S1? Pain in the spine when sitting in the car for about 2-3 hours.
Administrators
admin
jhin.cоm1951.24.10In your case, you can assume two reasons - either pinching of nerves at the spinal level, or problems with the vessels of the legs, which leads to impaired nutrition of the tissues and the appearance of these symptoms. I would have made an ultrasound of the vessels of the legs and consulted with a competent neurologist. Problems in the nerves, it seems, really is not.
Guests
oleg212
I once took thiogamma because the left little finger was numb. Like helping, but then stopped taking. Somewhere for half a year and now on the right hand is the same! Do you think I should continue the course?
Administrators
admin
oleg212And were they examined for diabetes? Have a neurologist been consulted? To say so for sure in your situation that Tiogamma can not help. Perhaps, the medicine will help in eliminating the neurological symptoms, but the problem in the body will remain. So I would take care of myself and pass the necessary minimum of tests for a primary examination and consult a neurologist.
Guests
olga
Can the temperature rise after the first dropper?
Administrators
admin
olga, Temperature increase with the use of Thiogamma is not noted in the instructions. I admit the individual reaction of the patient's body to the introduction of the drug in the form of hyperthermia, but this must be looked at as though alive.
Guests
Inna
I do not understand why in case of stroke use this medicine? My left hand refused and when I started to stab this medicine, my hand improved significantly and started to move my fingers and this at the first use.
Administrators
admin
InnaTreatment is prescribed - treatment helped. Why should you fool yourself with unnecessary terms or what will my answer give you that Tiogamma improves endoneural blood flow, increases the glutathione content to physiological significance.
Guests
Olga
Today we delivered the first drop of thiogamma.About three hours after her was very bad, weakness, nausea, legs as if not mine, tremors increased extremity. Prior to that, taking Oktalipen in pill was all right. I think I will refuse the second dropper.
Guests
Marina89
Good evening, tell me whether it is possible to put a dropper with this medication in the morning or evening. Is there any time of day when Tiogamma is contraindicated?
Administrators
admin
Marina89, The time of day does not affect the metabolism of the drug Tiogamma, so you can take the medicine when it is convenient and allows the operating time of the treatment room.
Guests
sonata
Good afternoon! While taking the drug (droppers N10, pills 2 months.), The symptoms of polyneuropathy are sufficiently weakened. But after the drug was withdrawn, they returned again, even worse.
Guests
Lyudmila
While there are no concrete conclusions, at least intensification of subjective sensations in a leg is not present after reception of two courses of tablets tiogamma.But there is a question: how to combine the reception of thiogamma and eutirox - in both cases it is necessary on an empty stomach, moreover, after eutiroksa it is undesirable, as it is said in the instruction, during 4 hours reception of other drugs. Sincerely, Ludmila.
Administrators
admin
Lyudmila, Take Eutiroks in the morning, after half an hour of Thiogamma, then in half an hour food intake is allowed. Other options in your case, I do not see, but Eutiroks take on an empty stomach is priority than Thiogamma.
Guests
RINA
When taking thiogamma 600 (course of 90 tablets), there were periodic dizziness and excessive weakness, tremor of the extremities, involuntary twitching of the muscles of the eyelids, as well as a change in taste - the food began to seem tasteless, as if chewing foam, and the drinks - as if diluted ten times with water.
No pleasure from eating! Waiting for the course to finish and maybe then the taste will recover.
Visitors
Votulei
Tell me, please, Tioktatsid and Tiogamma, which is better? Both drugs are Germany, but Tioctacid costs more with the same dosage and composition.
Administrators
admin
Votulei, No difference. The active substance of the drugs is the same, so we can talk about a complete analogy. Both are imported. I would take one that is cheaper.
Guests
Komarov Edward Atlasovich
Tiogamma helps with hepatitis C.
Guests
olga
I drip one patient with thiogamma, pains began in the right hypochondrium. Could this be?
Administrators
admin
olga, Maybe. I began to notice recently that all drugs that affect carbohydrate metabolism in the body (especially reducing the level of sugars in the blood) can provoke changes and various sensations in the liver. Although there is no direct indication of pain in the area of ​​the liver with infusions of the preparation of Thiogamma in the manual.
Visitors
afrodita8
adminWhether It is possible to accept Tiogamma 600 mg once a day at a varicose and a lymphostasis. Tioctic acid was prescribed by a neurologist. In side effects, thrombophlebitis is written, and the neurologist did not even warn and asked if there were any problems in this regard.How dangerous is it to take Tioctic acid for vein problems?
Administrators
admin
afrodita8, None of the diseases you indicated is not a contraindication to taking the drug Tiogamma, so the neurologist is right. A side effect in the form of thrombophlebitis is present, but this is the probability, moreover, fixed in a small number of patients who took Tiogamma, and not the fact that the drug administration led to such consequences, but the rules dictate indicating this effect in the instruction.
Guests
Elena4163
Good afternoon! Whether prompt it is possible to enter intravenously Tiogamma and to accept in tablets Vipidiju. Are these two drugs compatible?
Administrators
admin
Elena4163, Tiogamma and Vipidia preparations are compatible and can potentiate a mutual positive effect, especially regarding hypoglycemic drugs, which may require adjustment of the dosage of Vipidia. In the rest, additional side effects when using the medicines mentioned in the question should not be.
Guests
NIGARA
Hello.Can I take thiogamma with diclofenac?
Administrators
admin
NIGARA, Can. According to the instructions for additional negative side effects with the joint use of drugs Tiogamma and Diclofenac should not be.
Visitors
ledialka
After what time after taking an empty stomach of Tiogamma, you can drink a glass of honey water (1 tsp of natural honey per glass of water at room temperature)?
Administrators
admin
ledialka, Standard, like any food, half an hour after taking the drug Tiogamma you can drink this syrup.
Visitors
gabriella
Good evening. I'm ill with diabetes for 23 years, I'm 39 years old. Recently began to grow dumb toes and feet, the regge shows a sharply reduced blood supply to both legs, the neurologist, checking the current said sharply reduced sensitivity. And really I go, as in socks all the time. Dripped for a long time berlitionom 600, now doctors insist on tiogamma 600. But this is a generic Berlition, than tiogamma can be better than berlitiona?
Administrators
admin
gabriella, Too so I think. If the effect of using Berlition is not, then most likely, and from the use of Tiogamma it will not be, although the salts of thioctic acid in these medicines are different. Try to find a neurologist, whose curative horizon is not limited to the use of drugs solely based on thioctic acid.
Visitors
2201194869
Hello. Whether it is possible to accept simultaneously a metformin canon (it is appointed by the endocrinologist - prediabetes) and tiagamma (okolipen), appointed gastroenterologist - concomitant diagnosis - nonalcoholic fatty liver disease? At the moment, I have not completed taking a course of mexidol, appointed by a cardiologist.
Administrators
admin
2201194869, All three drugs are well combined. According to the instructions and from the experience of using additional negative consequences from such combinations should not be. Moreover, Tiogamma can enhance the action of Metformin and other hypoglycemic agents. Sometimes this may require adjusting the dosage of medications taken toward their decrease.
Visitors
med.lar
I have a question. Is thiogamma combined with capillary, selenium, calcium D3, vitamins B9 and B12, iodomarin and lecithin?
Administrators
admin
med.lar, According to the instructions to the relevant drugs, there are no restrictions on the use of the drugs mentioned in the questionnaire in the same therapy scheme, therefore, it is not possible to share additional side effects.
Guests
Guzel
Assigned thiogamma intravenously, revered pobochku, now scary. And lowers the pressure, I already have a low - 104/70. And how will the tablet have the same effect?
Administrators
admin
GuzelIf side effects are present on the injectable form of the drug, then most likely they will be on a tablet form, with the exception of reactions at the injection site, which are specific for stabbing. Adverse reactions are the exception rather than the constant constant intake of any medication.
Guests
Guzel
I started to drink in pills, now I want to switch to intravenous, I transfer normally. And how does the liver affect thiogamma?
Administrators
admin
Guzel, Exclusively positive - improves the functional state of the liver and improves the work of this body.

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