Tiogamma - instructions for use, reviews, analogs and forms of release (tablets 600 mg, injections in ampoules for injections in droppers) of the drug for the treatment of diabetic and alcoholic polyneuropathy in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Tiogamma. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tiogamma in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tiogamma in the presence of existing structural analogues.Use for the treatment of diabetic and alcoholic polyneuropathy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Tiogamma metabolic drug. Thioktovaya (alpha-lipoic) acid is an endogenous antioxidant (binds free radicals), it is synthesized in the body by oxidative decarboxylation of alpha-keto acids. As a coenzyme mitochondrial multienzyme complexes is involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance.
Participates in the regulation of lipid and carbohydrate metabolism, affects the exchange of cholesterol, improves liver function, has a detoxification effect in poisoning with salts of heavy metals and other intoxications. Has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects. Improves trophic neurons.
With diabetes, thioctic acid improves endoneural blood flow,increases the content of glutathione to a physiological value, which as a result leads to an improvement in the functional state of peripheral nerve fibers in diabetic polyneuropathy.
Composition
Thioctic acid + auxiliary substances.
Pharmacokinetics
After ingestion, Tiogamma is rapidly and almost completely absorbed from the digestive tract. At simultaneous reception with food absorption decreases. Bioavailability - 30-60% due to the effect of "first passage" through the liver. Metabolized in the liver by side chain oxidation and conjugation. Thioctic acid and its metabolites are excreted by the kidneys (80-90%), in a small amount - in unchanged form.
Indications
- diabetic polyneuropathy;
- alcoholic polyneuropathy.
Forms of release
Tablets coated with 600 mg.
Solution for infusions (in droppers).
Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).
Instructions for use and how to use them
Pills
Assign inside 600 mg (1 tablet) 1 time per day.
Tablets are taken on an empty stomach, without chewing, with a small amount of liquid.
The duration of the course of treatment is 30-60 days, depending on the severity of the disease.It is possible to repeat the course of treatment 2-3 times a year.
Ampoules
At the beginning of the course of treatment, the drug is administered intravenously at a dose of 600 mg per day (1 ampoule concentrate for solution for infusion or 1 bottle of solution for infusion) for 2-4 weeks. Then you can continue taking the drug inside at a dose of 600 mg per day.
Rules for the preparation and administration of an infusion solution (how to chop Tiogamma)
For the preparation of the infusion solution, the contents of 1 ampoule concentrate (contains 600 mg of thioctic acid) are mixed with 50-250 ml of 0.9% sodium chloride solution.
Immediately after preparation, the vial with the infusion solution is immediately covered with the attached light-protecting case. thioctic acid is sensitive to light. The infusion solution should be administered immediately after preparation. The maximum storage time of the prepared solution for infusions is no more than 6 hours.
When using a ready-made solution for infusions, the vial with the drug is taken out of the box and immediately covered with the attached light-protective case, tk. thioctic acid is sensitive to light. Infusion is produced directly from the vial.
Enter slowly, about 1.7 ml / min, for 30 min.
Side effect
- point bleeding in mucous membranes, skin;
- thrombocytopenia;
- hemorrhagic rash (purpura);
- thrombophlebitis;
- systemic reactions (itching, nausea, discomfort) until the development of anaphylactic shock;
- hives;
- change or violation of taste sensations;
- cramps right up to an epileptic fit;
- diplopia;
- eczema;
- rash;
- irritation, flushing or swelling (at the injection site);
- in the case of rapid administration of the drug may increase intracranial pressure (there is a feeling of heaviness in the head), difficulty breathing.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- children's age till 18 years;
- hypersensitivity to thioctic acid or other components of the drug.
Application in pregnancy and lactation
The drug Tiogamma is contraindicated in pregnancy and lactation (breastfeeding).
Use in children
The drug is contraindicated in children and adolescents under the age of 18 years.
special instructions
Patients with diabetes require constant monitoring of blood glucose concentration, especially at the initial stage of therapy. In some cases, it is necessary to reduce the dose of insulin or an oral hypoglycemic drug in order to avoid the development of hypoglycemia.If symptoms of hypoglycemia occur (dizziness, increased sweating, headache, visual disturbances, nausea), discontinue therapy immediately. In isolated cases with the use of Thiogamma in patients with a lack of glycemic control and in a severe general condition, serious anaphylactic reactions may develop.
Drinking alcohol during therapy with Thiogamma reduces the therapeutic effect and is a risk factor that contributes to the development and progression of neuropathy. During treatment with Tiogamma, you should refrain from drinking alcohol.
Impact on the ability to drive vehicles and manage mechanisms
The use of Thiogamma does not affect the ability to drive a vehicle and work with other mechanisms.
Drug Interactions
Thioctic acid reduces the effectiveness of Cisplatin while taking it, and also reacts with metal-containing drugs, such as iron and magnesium preparations.
Thioctic acid reacts with sugar molecules, forming hardly soluble complexes, for example with a solution of levulose (fructose).
Tiogamma enhances the anti-inflammatory effect of glucocorticosteroids (GCS).
With the simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may be enhanced.
Ethanol (alcohol) and its metabolites weaken the action of thioctic acid.
Pharmaceutical interaction
The infusion solution of thioctic acid is incompatible with the Dextrose solution, Ringer's solution and with solutions reacting with disulfide and SH-groups.
Analogues of the drug Tiogamma
Structural analogs for the active substance:
- Alpha lipoic acid;
- Berlition 300;
- Berlition 600;
- Lipamid tablets;
- Lipoic acid;
- Liptiokson;
- Neurolephone;
- Octolipen;
- Thiocacid 600;
- Tioctacide BV;
- Thiolept;
- Thiolipone;
- Espa Lipon.
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