Clindacine - instructions for use, reviews, analogs and forms of release (vaginal suppositories 100 mg, cream or gel 2%, B Prolong) drug for the treatment of bacterial vaginosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Clindacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Clindacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Clindacin in the presence of existing structural analogues. Use for the treatment of bacterial vaginosis, vaginitis and vulvitis in adults, children,as well as during pregnancy and lactation.

Clindacin - antibiotic from the group of lincosamides, possesses a wide spectrum of antimicrobial action. The mechanism of action is due to binding to the 50 S subunit of the ribosomal membrane and suppression of protein synthesis in the microbial cell. It acts bacteriostatically. With respect to a number of gram-positive cocci, a bactericidal effect is possible.

It is active against Staphylococcus spp. (Staphylococcus aureus) (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae (Streptococcus), Corynebacterium diphtheriae, Mycoplasma spp. (mycoplasma), anaerobic and microaerophilic Gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacterium spp. and Actinomyces israelii.

Most strains of Clostridium perfringens are sensitive to clindamycin, but other species of Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, therefore, in cases of infections caused by Clostridium spp., the definition of an antibioticogram is recommended.

There is a cross-resistance between Clindamycin and linkomycin.

Composition

Clindamycin (in the form of phosphate) + auxiliary substances (Clindacin).

Butoconazole nitrate + Clindamycin phosphate + excipients (Clindacin B Prolong).

Pharmacokinetics

After a single intravaginal administration of clindamycin in a dose of 100 mg, 4% of the administered dose is systemically absorbed.

Indications

• bacterial vaginosis, caused by microorganisms sensitive to the preparation.

Forms of release

Vaginal cream 2% (sometimes mistakenly called a gel or ointment).

Candles vaginal 100 mg in a package of 3 pieces.

There are no other dosage forms, whether it's a pill or a solution.

Instructions for use and how to use them

Candles

Assign intravaginally 1 candle 1 time per day just before bedtime, for 3-7 consecutive days.

Before use, one suppository is freed from the contoured package, previously cutting the film along the contour of the suppository, is inserted, if possible, deep into the vagina, in a prone position.

Cream

Introduced intravaginally with the help of an applicator.

The recommended single dose is 100 mg of clindamycin (one complete applicator), preferably at bedtime for 3-7 days.

Cream B Prolong

Introduced intravaginally with the help of an applicator. It is used once, preferably before bedtime. The recommended dose is 1 complete applicator (5 g of cream, which corresponds to 100 mg of butoconazole nitrate and 100 mg of clindamycin). The course of treatment is daily for 3 days.

Instructions for use

Disposable applicators, supplied with the package, are designed to correctly insert the cream into the vagina.

1. Remove the cap of the tube with cream. Screw the plastic applicator onto the threaded neck of the tube.
2. Squeezing the tube from the opposite end, gently squeeze the cream into the applicator. The applicator piston moves independently as the required volume is filled. The applicator is full when its piston comes to a stop.
3. Lying on your back, take the applicator horizontally and insert it into the vagina as far as possible, but so as not to cause unpleasant sensations.
4. Slowly push the plunger all the way.
5. Carefully remove the applicator from the vagina and discard it.

Side effect

• cervicitis;
• vaginitis;
• vulvovaginal irritation;
• reversible leukopenia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia;
• maculopapular rash;
• hives;
• itching;
• in rare cases - pseudomembranous enterocolitis.

Contraindications

• 1 trimester of pregnancy;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Intravaginal application of Clindacin in pregnancy is possible only in the event that,when the intended use for the mother exceeds the potential risk to the fetus. Clindamycin penetrates the placental barrier into the fetal circulatory system.

Clindamycin is excreted in breast milk. With caution, it is recommended to prescribe the drug during lactation. For the duration of treatment, breastfeeding should be discontinued.

special instructions

Vaginal suppositories are not recommended for use with other intravaginal drugs.

With prolonged use of the drug, excessive growth of insensitive microorganisms, especially fungi of the genus Candida (candida), is possible.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the ability to concentrate and the speed of psychomotor reactions.

Drug Interactions

Clindacin enhances the action of drugs rifampicin, aminoglikozidov - streptomycin, gentamicin.

Strengthens the muscle relaxation caused by n-holinoblokatorami.

Clindacin is incompatible with erythromycin, ampicillin, diphenylhydantoin derivatives, barbiturates, aminophylline, Calcium gluconate and magnesium sulfate.

Analogues of the drug Klindacin

Structural analogs for the active substance:

• Dalacin;
• Dalacine TS phosphate;
• Mirror;
• Klimitsin;
• Clindamycin;
• Klindatop;
• Clindefer;
• Klindes;
• Klindovit.

Similar medicines:

Other medicines: