Cardiomagnet - instructions for use, reviews, analogs and forms of release (tablets 75 mg and 150 mg) of the drug for the treatment and prevention of cardiovascular diseases, including during pregnancy
In this article, you can read the instructions for using the drug Cardiomagnet. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Cardiomagnet in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of the Cardiomagnet in the presence of existing structural analogs. Use to treat the prevention of cardiovascular disease, myocardial infarction and thrombosis in adults, including during pregnancy and lactation.
Cardiomagnet - Non-steroidal anti-inflammatory drug, antiaggregant. The mechanism of action of Acetylsalicylic acid (the active substance of the drug Cardiomagnesium) is irreversible inhibition of the enzyme COX-1, which blocks the synthesis of thromboxane A2 and inhibits platelet aggregation. It is believed that acetylsalicylic acid has other mechanisms for suppressing platelet aggregation, which expands its use in various vascular diseases. Acetylsalicylic acid also has an anti-inflammatory, analgesic and antipyretic effect.
Magnesium hydroxide, which is part of the Cardiomagnet, protects the mucous membrane of the gastrointestinal tract from the effects of acetylsalicylic acid.
Pharmacokinetics
After taking the drug inside, acetylsalicylic acid (aspirin) is absorbed from the digestive tract almost completely.
Magnesium hydroxide (in the applied doses) does not affect the bioavailability of acetylsalicylic acid.
Indications
- primary prevention of cardiovascular diseases, such as thrombosis and acute heart failure in the presence of risk factors (eg, diabetes, hyperlipidemia, hypertension, obesity, smoking, old age);
- prevention of recurrent myocardial infarction and thrombosis of blood vessels;
- prevention of thromboembolism after surgical interventions on vessels (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty);
- unstable angina.
Forms of release
Tablets, film-coated 75 mg and 150 mg.
Instructions for use and dosage
Tablets should be swallowed whole, washed down with water. If desired, the tablet can be broken in half, chewed or pre-grated.
For the primary prevention of cardiovascular diseases, such as thrombosis and acute heart failure in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, elderly age), 1 tablet of cardiomagnet containing acetylsalicylic acid (aspirin) in dose of 150 mg in the first day, then 1 tablet of Cardiomagnesium containing acetylsalicylic acid in a dose of 75 mg once a day.
For the prevention of repeated myocardial infarction and blood vessel thrombosis, 1 tablet of Cardiomagnesium containing acetylsalicylic acid in a dose of 75-150 mg once a day is prescribed.
For the prevention of thromboembolism after surgical interventions on vessels (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty), one tablet of Cardiomagnum containing acetylsalicylic acid in a dose of 75-150 mg once a day is prescribed.
With unstable angina, 1 tablet of Cardiomagnet containing acetylsalicylic acid in a dose of 75-150 mg once a day is prescribed.
Side effect
- hives;
- angioedema;
- anaphylactic reactions;
- heartburn;
- nausea, vomiting;
- pain in the abdomen;
- ulcers of the mucous membrane of the stomach and duodenum;
- gastrointestinal bleeding;
- perforation of the stomach or duodenal ulcer;
- stomatitis;
- esophagitis;
- strictures;
- colitis;
- bronchospasm;
- increased bleeding;
- anemia;
- hypoprotrombinemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis;
- dizziness;
- drowsiness, insomnia;
- headache;
- noise in ears.
Contraindications
- hemorrhage in the brain;
- propensity to bleedings (insufficiency of vitamin K, thrombocytopenia, hemorrhagic diathesis);
- The bronchial asthma, induced by the intake of salicylates and NSAIDs;
- erosive-ulcerative lesion of the gastrointestinal tract (in the phase of exacerbation);
- gastrointestinal bleeding;
- renal failure of severe degree (CC <10 ml / min);
- deficiency of glucose-6-phosphate dehydrogenase;
- simultaneous reception with methotrexate (> 15 mg per week);
- 1 and 3 trimesters of pregnancy;
- lactation period (breastfeeding);
- children and adolescents under 18;
- hypersensitivity to acetylsalicylic acid, excipients of the drug and other NSAIDs.
Application in pregnancy and lactation
The use of cardiomagnesium in high doses in the first trimester of pregnancy is associated with an increased incidence of fetal developmental defects. In the 2nd trimester of pregnancy, salicylates can be prescribed only with strict risk and benefit evaluation. In the trimester of pregnancy, salicylates in high doses (> 300 mg per day) cause inhibition of labor, premature closure of the arterial duct in the fetus, increased bleeding in the mother and fetus, and the appointment immediately before childbirth can cause intracranial hemorrhages, especially in premature infants. The appointment of salicylates in the first and third trimester of pregnancy is contraindicated.
Salicylates and their metabolites are excreted in small amounts with breast milk.The accidental intake of salicylates during lactation is not accompanied by the development of adverse reactions in the child and does not require the cessation of breastfeeding. However, with prolonged use of the drug or its administration in a high dose, breast-feeding should be stopped immediately.
special instructions
Take the drug Cardiomagnesium should be after the appointment of a doctor.
Acetylsalicylic acid can provoke bronchospasm, as well as cause attacks of bronchial asthma and other reactions of hypersensitivity. Risk factors are the presence of bronchial asthma in history, hay fever, nasal polyposis, chronic diseases of the respiratory system, as well as allergic reactions (skin rash, itching, urticaria) to other drugs.
Acetylsalicylic acid can cause bleeding of varying severity during and after surgical interventions.
The combination of acetylsalicylic acid with anticoagulants, thrombolytics and antiplatelet drugs is accompanied by an increased risk of bleeding.
The intake of acetylsalicylic acid in low doses can provoke the development of gout in predisposed individuals (having decreased uric acid excretion).
The combination of acetylsalicylic acid with Methotrexate is accompanied by an increased incidence of side effects from the hematopoiesis.
Admission Cardiomagnesium in high doses has a hypoglycemic effect, which must be borne in mind when prescribing it to patients with diabetes mellitus receiving hypoglycemic drugs.
When combined appointment of GCS and salicylates should be remembered that during treatment, the level of salicylates in the blood is reduced, and after the abolition of SCS, an overdose of salicylates is possible.
It is not recommended to combine acetylsalicylic acid with ibuprofen, as the latter worsens the beneficial effect of acetylsalicylic acid on life expectancy.
Excess dose of acetylsalicylic acid is associated with a risk of gastrointestinal bleeding.
When combined with acetylsalicylic acid and alcohol, the risk of damage to the mucosa of the gastrointestinal tract and prolonging the time of bleeding is increased.
Impact on the ability to drive vehicles and manage mechanisms
There is no evidence of any influence of the Cardiomagnet on the ability of patients to drive vehicles and work with mechanisms.
Drug Interactions
With simultaneous use of acetylsalicylic acid increases the effect of the following drug substances: methotrexate (by reducing renal clearance and displace it from its association with proteins), Heparin anticoagulants (due to abnormalities of platelet function and displacement anticoagulants from binding with proteins), thrombolytic and antiplatelet drugs (ticlopidine), Digoxin (due to reduction of its renal excretion), hypoglycemic agents: insulin and sulfonylurea derivatives (due to hypoglycaemia iCal properties of the acetylsalicylic acid in high doses and displacement of sulfonylurea derivatives association with proteins), valproic acid (due to repression of its association with proteins).
Additive effect is observed with simultaneous administration of acetylsalicylic acid with ethanol (alcohol).
Acetylsalicylic acid reduces the effect of uricosuric agents (benzbromaron) due tubular competitive elimination of uric acid.
By enhancing the elimination of salicylates, systemic GCSs weaken their action.
Antacids and cholestyramine with simultaneous use reduce the absorption of Cardiomagnesium.
Analogues of the drug Cardiomagnol
The cardiomagnesium does not have a structural analogue for the active substance. However, there is a large number of combination preparations containing acetylsalicylic acid as an active substance and which can be considered as substitutes:
- Agro;
- Godasal;
- Coplawix.
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