Walsz - instructions for use, reviews, analogs and formulations (tablets 40 mg, 80 mg and 160 mg, with hydrochlorothiazide H form) drug for the treatment of hypertension and pressure reduction in adults, children and pregnancy
In this article, you can read the instructions for using the drug Wales. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Valz in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Wales in the presence of existing structural analogues. Use to treat hypertension and reduce blood pressure in adults, children,as well as during pregnancy and lactation.
Wales - a peripheral vasodilator, has an antihypertensive effect. The specific blocker of AT1-receptors of angiotensin 2, does not inhibit ACE. Does not affect the content of total XC, TG, glucose and uric acid in the blood.
The onset of the effect occurs 2 hours after ingestion, the maximum after 4-6 hours; the duration of the action is more than 24 hours. After regular administration, the maximum decrease in blood pressure occurs in 2-4 weeks. There is no withdrawal syndrome with sudden discontinuation of admission.
Composition
Valsartan + excipients.
Valsartan + hydrochlorothiazide + auxiliary substances (Vals H).
Pharmacokinetics
After taking the drug inside absorption is fast, the degree of absorption is variable. The average value of absolute bioavailability is 23%. The binding with plasma proteins (mainly with albumins) is high - 94-97%. With repeated use of valsartan, no changes in the kinetic parameters were noted. When taking the drug in a dose 1 time a day, there was an insignificant cumulation of valsartan. Pharmacologically inactive hydroxymetabolite is found in blood plasma in low concentrations.After ingestion, 83% of Valsartan is excreted with bile through the intestine and 13% by the kidneys, mostly unchanged.
The concentration of valsartan in the blood plasma does not differ between men and women.
When combined with valsartan, the systemic bioavailability of hydrochlorothiazide is reduced by about 30%, hydrochlorothiazide itself does not significantly affect the kinetics of valsartan. The noted interaction does not affect the efficiency of the combined application.
Indications
- arterial hypertension;
- chronic heart failure (2-4 functional class according to NYHA classification) - as part of complex therapy (excluding combination of valsartan + ACE inhibitor + beta adrenoblocker);
- with the aim of increasing the survival rate of patients with acute myocardial infarction (period from 12 hours to 10 days) complicated by left ventricular failure and / or left ventricular systolic dysfunction, with stable hemodynamic parameters.
Forms of release
Tablets coated with 40 mg, 80 mg and 160 mg.
Tablets coated with 80 mg + 12.5 mg, 160 mg + 12.5 mg and 160 mg + 25 mg (Vals H).
Instructions for use and dosing regimen
Assign inside, regardless of food intake, drinking with a sufficient amount of liquid.
With arterial hypertension, the recommended initial dose of Vals is 80 mg once a day. The hypotensive effect develops in the first 2 weeks of therapy. The maximum effect is achieved after 4 weeks of taking the drug. In patients for whom a daily dose of 80 mg does not give the desired therapeutic effect, it is recommended to increase the daily dose to 160 mg. Additionally, another antihypertensive agent (e.g., a diuretic) may be administered.
For chronic heart failure, the recommended initial dose of Valz is 40 mg twice daily. With insufficient therapeutic effect, a gradual increase in the dose to 80 mg 2 times a day is required and with good tolerability - up to 160 mg 2 times a day. From the moment of the beginning of treatment with Valz until the maximum dose is reached, an interval of at least 2 weeks should be observed. The maximum daily dose is 320 mg in 2 divided doses. It is possible to lower doses while taking diuretics.
Valz can be used in combination with other medicines intended for the treatment of chronic heart failure.However, Valz should not be administered in combination with an ACE + beta-blocker inhibitor.
After myocardial infarction with stable hemodynamics, treatment can be started within 12 hours after acute myocardial infarction. The initial dose is 20 mg (1/2 tablet 40 mg) 2 times a day, followed by a dose increase of 40 mg, 80 mg, 160 mg twice a day for several weeks, until the maximum daily dose of 160 mg 2 times in day. Reaching a dose of 80 mg twice a day is recommended by the end of the second week of treatment, 160 mg twice a day - by the end of 3 months of therapy. The dose should be increased taking into account the tolerability of the drug. In the case of symptomatic arterial hypotension or with impaired renal function, the dose of Valz should be reduced.
In patients with mild and moderate impairment of liver function without development of cholestasis, the maximum daily dose of Valz should not exceed 80 mg.
WALZ H
The drug is taken orally, regardless of the time of ingestion, with a sufficient amount of liquid.
The following doses of Valz H are indicated in the ratio of valsartan / hydrochlorothiazide.
The recommended dose is 1 tablet of 80 / 12.5 mg once a day.If the drug is ineffective at this dose, it is recommended to increase the daily dose of Vals H to 160 / 12.5 mg, for those patients who show a further decrease in blood pressure, the daily dose of Valz H is 160/25 mg, respectively.
Patients with renal dysfunction with CK> 30 ml / min, as well as patients with mild or moderate liver function impairment in the absence of the phenomena of cholestasis do not need a dose adjustment of the drug Valz N.
Side effect
- orthostatic hypotension;
- a decrease in blood pressure;
- heart failure;
- vasculitis;
- bleeding;
- cough;
- diarrhea;
- abdominal pain;
- nausea;
- postural dizziness;
- fainting;
- insomnia;
- depression;
- decreased libido;
- neuralgia;
- headache;
- neutropenia, thrombocytopenia;
- serum sickness;
- hypersensitivity;
- angioedema;
- skin rash;
- itching;
- backache;
- muscle cramps;
- arthritis;
- myalgia;
- arthralgia;
- impaired renal function;
- acute renal insufficiency;
- viral infections;
- sinusitis;
- conjunctivitis;
- rhinitis;
- gastroenteritis;
- reduction of hemoglobin and hematocrit;
- increase in the concentration of urea nitrogen in the serum;
- feeling tired;
- asthenia;
- nose bleed;
- edema.
Contraindications
- violations of the liver, associated with obstruction of the biliary tract (including biliary cirrhosis, cholestasis);
- renal failure of severe degree (QC less than 10 ml / min), incl. patients on hemodialysis;
- pregnancy;
- lactation period (breastfeeding);
- age under 18 years (effectiveness and safety not established);
- lactose intolerance, galactosemia or syndrome of impaired glucose / galactose absorption;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
There are no data on the use of valsartan in pregnancy. Renal perfusion of the fetus, which depends on the development of the renin-angiotensin system (RAAS), begins to function in the third trimester of pregnancy. The risk to the fetus increases with the use of valsartan in the 2nd and 3rd trimesters. When establishing a pregnancy, therapy with Vals should be stopped immediately.
There is no data on the isolation of valsartan with breast milk. Therefore, if you need to use the drug inlactation period should decide whether to stop breastfeeding or to abolish valsartan therapy given its importance to the mother.
Use in children
Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).
special instructions
In patients with severe sodium deficiency in the body and / or reduced bcc, for example, due to the use of diuretics in high doses, in rare cases, severe arterial hypotension may develop at the onset of valsartan therapy. Before starting therapy with Vals, it is recommended to restore the electrolyte and fluid content in the body, in particular, by reducing the dose of diuretics.
The drug Valz can be used in conjunction with other drugs intended for the treatment of myocardial infarction, such as thrombolytics, acetylsalicylic acid, beta-adrenoblockers, statins and diuretics. Joint administration of ACE inhibitors is not recommended.
With renovascular hypertension, regular monitoring of urea and creatinine in the blood is necessary.
When combined with preparations containing potassium, its salts and preparations belonging to the group of potassium-sparing diuretics, regular monitoring of the level of potassium in the blood plasma is carried out.
In chronic heart failure at the beginning of treatment with the drug Valz, there may be a slight decrease in blood pressure, so it is recommended to monitor BP at the beginning of therapy.
Due to inhibition of RAAS, some patients may have renal function changes. In patients with severe chronic heart failure, whose renal function depends on RAAS activity, treatment with ACE inhibitors and angiotensin receptor antagonists may be accompanied by oliguria and / or increased azotemia and (rarely) acute renal failure and / or fatal.
It is not recommended joint use of Valz in patients with chronic heart failure, with ACE inhibitors and beta-blockers due to a possible increase in the risk of side effects.
Patients with bilateral or unilateral stenosis of the renal arteries need regular monitoring of creatinine and urea Nitrogen in the blood serum.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, care must be taken when driving vehicles and classesother potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.
Drug Interactions
When treating arterial hypertension with valsartan, there was no clinically significant interaction with other concomitant medications (for example, cimetidine, warfarin, digoxin, atenolol, amlodipine, glibenclamide, furosemide, indomethacin, hydrochlorothiazide).
Potassium-sparing diuretics, potassium preparations, potassium-containing salts, drugs that raise the level of potassium in the blood plasma (such as heparin) increase the risk of hyperkalemia.
Other antihypertensives and diuretics increase the antihypertensive effect of valsartan.
Ethanol (alcohol) enhances the hypotensive effect of the drug Valz.
The antihypertensive effect of the drug may be weakened when combined with non-steroidal anti-inflammatory drugs (NSAIDs), incl. with selective inhibitors of COX-2 and Acetylsalicylic acid at a dose of more than 3 g per day.
In a joint application with ACE inhibitors, a reversible increase in the concentration of lithium in plasma and the development of toxic effects were reported.
Very limited experience in the use of valsartan and preparations containing lithium.In the case of lithium-containing drugs, control of lithium concentration in blood plasma is recommended in patients receiving Valz.
Analogues of Val's drug
Structural analogs for the active substance:
- Valsartan;
- Valsafors;
- Walsakor;
- Diovan;
- Nortivan;
- Tantordio;
- Tareg.
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