Semax - instructions for use, reviews, analogs and formulations (0.1% and 1% drops in the nose) of the drug for the treatment of brain dysfunctions and encephalopathies in adults, children (including infants and newborns), and in pregnancy
In this article, you can read the instructions for using the drug Semax. Presented are the opinions of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Semax in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Semax in the presence of existing structural analogs. Use to treat brain dysfunctions and encephalopathies in adults, children (including infants and newborns),as well as during pregnancy and lactation.
Semax - has an original mechanism of neurospecific action on the central nervous system.
Semax is a synthetic analog of corticotropin, possessing nootropic properties and completely devoid of hormonal activity. The drug affects the processes associated with the formation of memory and learning. Semax strengthens attention when training and analyzing information, improves the consolidation of a memorable trace; improves adaptation of the body to hypoxia, cerebral ischemia, anesthesia and other damaging effects.
The drug is virtually non-toxic for a single and long-term administration. Does not show allergic, embryotoxic, teratogenic and mutagenic properties.
Composition
Methionyl-glutamyl-histidyl-phenylalanyl-prolyl glycyl-proline + auxiliary substances.
Pharmacokinetics
Absorbed from the mucous membrane of the nasal cavity, while digesting up to 60-70% in terms of the active substance. Semax is quickly distributed into all organs and tissues, it penetrates the blood-brain barrier. Upon entering the blood, Semax undergoes rapid enough degradation and excretion from the body with urine.
Indications
- intellectual-mnestic disorders in vascular lesions of the brain;
- states after traumatic brain injury, neurosurgical operations and anesthesia;
- discircular encephalopathy;
- transient disorders of cerebral circulation (TIA), as well as neurotic disorders of various genesis, incl. after ionizing radiation,
- the recovery period after a stroke;
- to enhance the adaptive capacity of the human body in extreme situations, the prevention of mental fatigue with monotonous operator activity in the most stressful periods of work under stressful conditions.
In ophthalmology:
- with atrophies of the optic nerve, neuritis inflammatory, toxic-allergic etiology.
In pediatrics:
- as a nootropic remedy in children aged 7 years in the treatment of minimal brain dysfunction (including ADHD - Attention Deficit Hyperactivity Disorder).
Forms of release
Drops in the nose 0.1% and 1%.
Instructions for use and dosing regimen
Drops in the nose 0.1%
Semax is applied intranasally, using a vial capped with a plastic stopper pipet.
One drop of the standard solution contains 50 μg of active substance. By pipetting, the drug solution in an amount of not more than 2-3 drops is injected into each nasal passage. If it is necessary to increase the dosage, the administration is carried out in several doses at intervals of 10-15 minutes.
In case of intellectual-mnestic disorders in vascular lesions of the brain, discircular encephalopathy, transient disorders of cerebral circulation, a single dose is 200-2000 μg (at a rate of 3-30 μg / kg).
The daily dose of 800-8000 mcg (at the rate of 7-70 mkg / kg).
The drug is prescribed 2-3 drops in each nasal passage 4 times a day for 10-14 days, if necessary, the treatment course is repeated.
After craniocerebral trauma, neurosurgical operations and narcosis, a single dose is 1400-3500 μg (40-50 μg / kg) 3 times a day for 3-5 days. If necessary, the course of treatment is extended to 14 days.
To increase the adaptive capacity of the human body and prevent mental fatigue 3-5 days 2-3 drops in each nasal passage 2-3 times in the morning. The daily dose of 400-900 mcg per day. If necessary, repeat the treatment.
With diseases of the optic nerve, the drug is digested 2-3 drops in each nasal passage 2-3 times a day. The daily dose of 600-900 mcg per day. The course of treatment is 7-10 days.In addition, the drug can be administered by endonasal electrophoresis. The drug is injected from the anode. Current strength 1 mA, duration of exposure 8-12-15 minutes.
The daily dose of 400-600 mcg per day. The course of treatment is 7-10 days.
In pediatrics: in children from 7 years. With minimal brain dysfunction: 1-2 drops in each nasal passage (at a rate of 5-6 μg / kg) 2 times a day (morning and afternoon). The daily dose of 200-400 mcg per day. The course of treatment is 30 days.
Nasal drops 1%
The volume of one drop is 0.05 ml (50 μl). One drop of the standard solution contains 500 μg of active substance.
For a stroke of moderate severity, 2-3 drops are injected into each nostril at a time, which is 2000 μg (4 drops or 0.2 ml) - 3000 μg (6 drops or 0.3 ml). Burial is carried out 3-4 times a day, with an interval between instillations of 3-4 hours. The daily dose is 6000 μg (12 drops or 0.6 ml) - 12,000 μg (24 drops or 1.2 ml).
In severe strokes, 3-4 drops are injected into each nostril at a time, which is 3000 μg (6 drops or 0.3 ml) - 4000 μg (8 drops or 0.4 ml). The instillation is carried out 4-5 times a day with an interval between instillations of 2.5-3 hours. The daily dose is 12000 μg (24 drops or 1.2 ml) - 20,000 μg (40 drops or 2.0 ml).
The drug is prescribed daily for 10 days.
Side effect
- slight irritation of the nasal mucosa.
Contraindications
- children's age till 7 years;
- pregnancy;
- lactation period;
- acute psychosis;
- disorders accompanied by anxiety;
- convulsions in the anamnesis;
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Contraindicated use of the drug during pregnancy and lactation.
Use in children
With minimal brain dysfunction, the drug is injected 1-2 drops into each nasal passage 2 times a day (morning and afternoon). The daily dose of 200-400 mcg per day. The course of treatment is 30 days.
Semax drops 0.1% are contraindicated in children under 7 years of age (including infants and newborns).
Semax drops 1% are contraindicated for use in children and adolescents under the age of 18 years.
special instructions
Without features.
Drug Interactions
Pharmaceutical. Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug is rapidly destroyed and does not enter the digestive tract.
Pharmacokinetic. Given the chemical structure of the drug (heptapeptide - a synthetic analog of adrenocorticotropic hormone, completely devoid of hormonal activity),the speed of absorption and the rate of entry into the blood, as well as the intranasal route of administration, the effect of other drugs on the pharmacokinetic parameters of Semax is not expected. Taking into account the method of introducing Semax (intranasal), it is undesirable to administer agents having a local vasoconstrictive effect when administered intranasally.
Analogs of the medicinal product Semax
Structural analogs for the active substance:
- Minisem.
Analogues for the pharmacological group (nootropics):
- Amylonosar;
- Aminalon;
- Vinpotropil;
- Gamalon;
- Ginkyo;
- Ginos;
- Gliatilin;
- Glycine;
- Glutamic acid;
- Gopantam;
- Hopantenic acid;
- Delecite;
- Demanol;
- Idebenon;
- Intelland;
- Combbitropyl;
- Cortexin;
- Cortexin for children;
- Lucetsam;
- Mexipridol;
- Mexiprim;
- Memotropized;
- Minisem;
- Neuromet;
- Noben;
- Nootropil;
- Noophen;
- Omaron;
- Pantogam;
- Pantokaltsin;
- Pikamilon;
- Picanoyl;
- Piraben;
- Piracesine;
- Piracetam;
- Pyriditol;
- Stamine;
- Tenoten;
- Thiocetam;
- Fezam;
- Fenibut;
- Phenotropil;
- Choline alphoscerate;
- Cebrilysin;
- Ceraxon;
- Cerebrial;
- Cerebrosolate;
- Cerebrolysin;
- Cerepro;
- Energol;
- Encephabol;
- The escotrope.
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