Tiotriazolin - instructions for use, reviews, analogs and formulations (100 mg and 200 mg tablets, injections for injections, 1% eye drops, suppositories) for the treatment of hepatitis and cirrhosis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Tiotriazolin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tiotriazolin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tiotriazoline in the presence of existing structural analogs.Use for the treatment of hepatitis and cirrhosis of the liver in adults, children, as well as during pregnancy and lactation.

Tiotriazolin antioxidant drug. The pharmacological effect is due to anti-ischemic, antioxidant, membrane-stabilizing and immunomodulating properties. Prevents the death of hepatocytes, reduces the degree of their fatty infiltration and the spread of centrolobular liver necrosis, promotes the regeneration of hepatocytes, normalizes protein, carbohydrate, lipid and pigment exchanges. Increases the amount of synthesis and excretion of bile, normalizes its chemical composition.

Tiotriazolin enhances the compensatory activation of anaerobic glycolysis, reduces the inhibition of oxidation in the Krebs cycle, while maintaining the intracellular ATP. The drug activates the antioxidant system and inhibits the oxidation of lipids in the ischemic areas. Improves rheological properties of blood (activates the fibrinolytic system).

Composition

Morpholinium-methyl-triazolyl-thioacetate (thiotriazoline) + auxiliary substances.

Pharmacokinetics

Biological availability of the drug - 64.5% is not dependent on food intake, binding to blood proteins does not exceed 10%.In significant concentrations, the drug accumulates in the tissues of the heart, liver, spleen, rectum and kidneys in small amounts - in the lungs and small intestine. Tiotriazolin is excreted mainly by the kidneys.

Indications

• toxic liver damage, incl. alcoholic, viral and medicinal origin (taking antibiotics, antitumor drugs, antituberculosis, antiviral drugs, tricyclic antidepressants, oral contraceptives);
• chronic alcoholic hepatitis of minimal and moderate activity;
• chronic viral hepatitis;
• fatty degeneration of the liver;
• cirrhosis of the liver;
• traumatic and burns of the eyeball;
• in the complex therapy of inflammatory-dystrophic diseases of the cornea and viral conjunctivitis;
• as a preventive agent in patients with an increased risk of developing asthenopia, inflammatory eye diseases, as well as dry eye syndrome.

Forms of release

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Tablets of 100 mg and 200 mg.

Eye drops 1%.

Candles rectal and intravaginal.

Instructions for use and how to use them

Pills

Inside.Tiotriazolin appoint 1 to 2 tablets 3-4 times a day for 20-30 days.

The duration of treatment is determined by the doctor individually depending on the severity and features of the course of the disease.

Ampoules

For chronic hepatitis in the first 5 days of Tiotriazolin, intramuscular injection of 2 ml 2.5% solution 2-3 times a day (2-3 times 50 mg) or intravenously 4 ml 2.5% solution (100 mg) slowly at a rate of 2 ml / min or drip (dropper) at a rate of 20-30 drops / min (2 ampules 2.5% solution is dissolved in 150-250 ml of physiological solution).

From 5 to 20 day of treatment appoint Tiotriazoline in tablets (100 mg 3 times a day). The course of treatment is 20-30 days.

Eye Drops

Drops of Tiotriazolin are intended for application in a conjunctival sac. The duration of administration and dose of thiotriazoline is determined by the physician.

Adults, as a rule, are prescribed 2 drops of the drug 3-4 times a day.

In severe lesions, it is recommended to combine eye drops with a solution for injections (which is injected subconjunctively or parabulbarno by 0.5 ml of a 1% solution once a day).

The duration of the application is usually 2 weeks, but if necessary, the course can be extended to 1 month.

When working at a computer to prevent the development of a dry eye symptom, it is usually recommended to apply 2 drops of the drug to each eye, after which the drops should be applied every 2 hours, during work at the computer.

Candles

Suppositories Tiotriazolin intended for rectal or intravaginal use. Enter the suppository should be deep in the rectum or vagina in the supine position. The duration of therapy and the dose of thiotriazoline is determined by the doctor.

In acute and chronic form of hepatitis, as well as cirrhosis, as a rule, rectal administration of 1 suppository is prescribed twice a day. The recommended duration of therapy is 2 to 4 weeks.

In inflammatory diseases of the rectum and sigmoid colon, as a rule, rectal administration of 1 suppository is prescribed twice a day.

With inflammatory-erosive lesions of the vaginal mucosa and cervix, as a rule, intravaginal administration of 1 suppository per day is prescribed. Depending on the course of the disease and concomitant therapy, it is allowed to increase the dose to 1 suppository twice a day.

The duration of local therapy, as a rule, is 1-2 weeks.

Side effect

• nausea;
• dry mouth;
• bloating;
• general weakness;
• dizziness;
• noise in ears;
• tachycardia;
• increased blood pressure;
• pain in the heart;
• arrhythmias;
• dyspnea;
• attacks of suffocation;
• hypersensitivity reactions;
• fever;
• angioedema;
• itching;
• hyperemia of the skin;
• hives;
• a feeling of tingling and redness at the injection site.

Contraindications

• kidney failure;
• childhood;
• pregnancy;
• lactation period;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Contraindicated use of the drug during pregnancy and lactation.

The drug Tiotriazoline in the form of eye drops can be prescribed for pregnant and lactating women.

Use in children

Contraindicated in childhood.

special instructions

Without features.

Drug Interactions

Data on drug interactions are not provided.

Analogues of the drug Tiotriazolin

Structural analogues of the active substance drug Tiotriazolin has not.

Analogues for the pharmacological group (hepatoprotectors):

• L Methionine;
• Antraliv;
• Berlition;
• Bondjigar;
• Brentzialle forte;
• Vitanorm;
• Gepa Merz;
• Gepabene;
• Hepatosan;
• Hepafor;
• Heptral;
• Dipan;
• Karsil;
• Laennek;
• Liv 52;
• Livedoksa;
• Methionine;
• Metrop;
• Moliksan;
• Octolipen;
• Ornitsetil;
• Progepar;
• Resalute Pro;
• Silegon;
• Silibinin;
• Sylimar;
• Silymarin;
• Thiolipone;
• Tyqveol;
• Urdoks;
• Ursodez;
• Ursodeoxycholic acid;
• Ursodex;
• Ursuliv;
• Ursor;
• Ursosan;
• Ursofalk;
• Phosphogliv;
• Phosphontsiale;
• Holudexan;
• Exxhol;
• Essentiale N;
• Essentiale forte N;
• Essential phospholipids;
• The Essler;
• Essliver forte.

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