Lucetsam - instructions for use, reviews, analogs and forms of release (tablets 400 mg, 800 mg and 1200 mg, injections in ampoules) drugs for the treatment of the consequences of stroke and mental retardation in adults, children and pregnancy

In this article, you can read the instructions for using the drug Lucetsam. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Luccam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lucetam in the presence of existing structural analogues. Use to treat the effects of stroke and mental retardation in adults, children, as well as in pregnancy and lactation.

Lucetsam - Nootropic preparation.Pyracetam (active ingredient of Lucetam) is a cyclic derivative of gamma-aminobutyric acid (GABA). Pyracetam directly affects the brain. Lucetam improves cognitive (cognitive) processes, such as learning ability, memory, attention, ability to remember, and also increases mental performance without developing a sedative and psychostimulating effect.

Has an influence on the central nervous system in various ways: it changes the speed of propagation of excitation in the brain, improves neuronal plasticity and metabolic processes in nerve cells. Improves the interaction between the cerebral hemispheres and synaptic conductivity in neocortical structures, increases mental performance, improves cerebral blood flow.

Lucetam improves microcirculation in the brain, affecting the rheological characteristics of the blood, and does not cause vasodilating action. Lucetam inhibits platelet aggregation and restores the elasticity of the erythrocyte membrane, as well as the ability of the latter to pass through the microcirculatory bed. Reduces the adhesion of red blood cells.In a dose of 9.6 g reduces the level of fibrinogen and von Willebrand factor by 30-40% and lengthens the time of bleeding.

Lucetam has a protective and restorative effect when brain function is impaired due to hypoxia, intoxication or trauma. Reduces the severity and duration of the vestibular nystagmus.

Composition

Piracetam + auxiliary substances.

Pharmacokinetics

After taking the drug inside Lucetsam quickly and almost completely absorbed from the digestive tract. Bioavailability of the drug is about 100%. Pyracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia. Does not bind to blood plasma proteins. Pyracetam penetrates the blood-brain barrier (BBB) ​​and the placental barrier. It is not metabolized in the body. It is excreted by the kidneys in an unchanged form - 80-100%, by renal filtration.

Indications

• symptomatic treatment of psycho-organic syndrome, in particular in elderly patients, accompanied by a decrease in memory, dizziness, reduced concentration of attention and general activity, mood changes, behavioral disorder, gait disturbance,as well as in patients with Alzheimer's disease and senile dementia of the Alzheimer's type;
• treatment of the consequences of ischemic stroke, such as speech disorders, emotional disorders, motor and mental activity;
• chronic alcoholism - for the treatment of psycho-organic and abstinence syndromes;
• in the period of recovery from trauma and intoxication of the brain;
• treatment of dizziness and related disorders of equilibrium, with the exception of dizziness of mental origin;
• in the complex therapy of low learning in children, especially in cases of acquiring specific skills of reading, writing, counting, which can not be explained by mental retardation, inadequate training or family situation;
• for the treatment of cortical myoclonia as a mono- or complex therapy.

Forms of release

Tablets coated with 400 mg, 800 mg and 1200 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosage regimen

Inside, the drug is prescribed in a daily dose of 30-160 mg / kg, the frequency of reception is 2-4 times a day.

Intravenous or intramuscular administration is prescribed in a daily dose of 30-160 mg / kg (3-12 g / day), the frequency of administration is 2-4 times a day.

With symptomatic treatment of chronic psychoorganic syndrome, depending on the severity of symptoms, 1.2-2.4 g per day is prescribed, and during the first week - 4.8 g per day.

When treating the consequences of stroke appoint 4.8 grams per day.

With alcohol withdrawal syndrome - 12 g per day. The maintenance dose is 2.4 g per day.

Treatment of dizziness and associated disorders of equilibrium appoint 2.4-4.8 g per day.

In cortical myoclonia, treatment starts with a dose of 7.2 grams per day, every 3-4 days the dose is increased by 4.8 g per day until a maximum dose of 24 g per day is reached. Treatment continues throughout the period of the disease. Every 6 months, an attempt should be made to reduce the dose or to cancel the drug, gradually reducing the dose by 1.2 g every 2 days in order to prevent an attack. In the absence of effect or a slight therapeutic effect, treatment is discontinued.

In the treatment of coma, as well as the difficulties of perception in persons with trauma, the drug is administered in / m or IV at an initial dose of 9-12 g per day, maintaining a dose of 2.4 g per day. Treatment continues for at least 3 weeks.

Children for correction of reduced learning is prescribed inside at a dose of 3.2 grams per day. Treatment continues throughout the school year.

In elderly patients, the dose is corrected in the presence of renal failure and with prolonged therapy it is necessary to monitor the functional state of the kidneys.

In patients with impaired liver function, correction of the dosing regimen is not required.

Lacetam tablets are taken during meals or on an empty stomach, washed down with liquid (water, juice).

The solution of Luccam for intramuscular or intravenous administration is compatible with the following infusion solutions: Dextrose 5%, 10%, 20%; fructose 5%, 10%, 20%; levulose 5%; sodium chloride 0.9%; dextran 40 - 10% in 0.9% solution of sodium chloride; dextran 100-6% in a 0.9% solution of sodium chloride; Ringer's solution; Ringer's solution with lactate; mannitol-dextran; hydroxyethyl starch 6%. Infusion solutions of pyracetam are stable for at least 24 hours.

Side effect

• hyperkinesia;
• nervousness;
• drowsiness;
• depression;
• dizziness;
• headache;
• ataxia;
• disturbance of balance;
• exacerbation of epilepsy;
• insomnia;
• confusion;
• excitation;
• anxiety;
• hallucinations;
• increased sexuality;
• increase in body weight;
• nausea, vomiting;
• diarrhea;
• pain in the stomach;
• dermatitis;
• itching;
• rashes;
• edema;
• asthenia.

Contraindications

• hemorrhagic stroke;
• the final stage of renal failure (with SC less than 20 ml / min);
• children under 1 year;
• pregnancy;
• lactation;
• hypersensitivity to pyracetam or pyrrolidone derivatives, as well as other components of the drug.

Application in pregnancy and lactation

Adequate and strictly controlled clinical studies on the safety of the drug during pregnancy have not been conducted.

Lucetam should not be administered during pregnancy, except in cases of extreme necessity.

Piracetam penetrates the placental barrier, excreted in breast milk. The concentration of Piracetam in the blood in newborns reaches 70-90% of its concentration in the blood of the mother.

If it is necessary to use lactation, breastfeeding should be discontinued.

Application in elderly patients

In elderly patients, the dose is corrected in the presence of renal failure and with prolonged therapy it is necessary to monitor the functional state of the kidneys.

Use in children

Children for correction of reduced learning is prescribed inside at a dose of 3.2 grams per day. Treatment continues throughout the school year. Contraindicated in children under 1 year.

special instructions

Due to the effect of piracetam on platelet aggregation, caution should be given to patients with hemostatic disorders, during major surgery or patients with symptoms of severe bleeding.

In the treatment of cortical myoclonia, sudden interruption in treatment should be avoided, which can lead to the resumption of seizures.

With prolonged therapy, elderly patients are recommended regular monitoring of renal function, if necessary, dose adjustment is performed depending on the results of the QC study.

It penetrates the hemodialysis apparatus through the filter membranes.

Influence on the ability to drive vehicles and work with mechanisms

Taking into account possible side effects, the patient should be careful when driving a car and working with mechanisms.

Drug Interactions

When used simultaneously with an extract of the thyroid gland, there may be increased irritability, disorientation and sleep disturbances.

No interaction with clonazepam, phenytoin, phenobarbital, sodium valproate has been observed.

Pyracetam in high doses (9.6 g per day) increases the efficacy of acenocoumarol in patients with venous thrombosis (there was a more pronounced decrease in platelet aggregation, fibrinogen, von Willebrand factors, viscosity of blood and plasma compared to acenocoumarol alone).

The possibility of changing the pharmacodynamics of Lutzam under the influence of other drugs is low, because 90% of the drug is excreted unchanged in the urine.

The administration of piracetam at a dose of 20 mg per day did not alter the peak and the concentration curve of antiepileptic drugs in serum (carbamazepine, phenytoin, phenobarbital, valproate) in epilepsy patients receiving the drug at a constant dose.

Co-administration with ethanol (alcohol) did not affect the serum concentration of piracetam, the concentration of ethanol in the blood serum did not change with the intake of 1.6 g of piracetam.

Analogues of Lucetam

Structural analogs for the active substance:

• Memotropized;
• Nootebril;
• Nootropil;
• Noocetam;
• Piraben;
• Pyramids;
• Pyramidal;
• Piracetam;
• Stamine;
• Cerebrial;
• The escotrope.

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