Afobazol - instructions for use, reviews, analogs and formulations (5 mg and 10 mg tablets) of the drug for the treatment of neurasthenia, anxiety disorders in adults, children and pregnancy. Indications and contraindications
In this article, you can read the instructions for using the drug Afobazol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Afobazol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Afobazol in the presence of existing structural analogues. Use for the treatment of neurasthenia, anxiety disorders, withdrawal syndrome in adults,children, as well as during pregnancy and lactation. Indications, contraindications and side effects of taking the drug.
Afobazol - derivative of 2-mercaptobenzimidazole, a selective anxiolytic, not belonging to the class of benzodiazepine receptor agonists. Prevents the development of membrane-dependent changes in the GABA receptor.
The drug has an anxiolytic effect with an activating component that is not accompanied by hypnosedative effects (sedative effect is detected in doses 40-50 times higher than ED50 for anxiolytic effect). The drug lacks muscle relaxant properties, a negative effect on memory and attention. When using the drug, drug dependence is not formed and withdrawal syndrome does not develop.
The effect of the drug is realized primarily as a combination of anxiolytic (anti-anxiety) and easily stimulating (activating) effects. Reduction or elimination of anxiety (concern, bad forebodings, fears, irritability), tension (fearfulness, tearfulness, anxiety, inability to relax,insomnia, fear), and therefore somatic (muscle, sensory, cardiovascular, respiratory, gastrointestinal symptoms), vegetative (dry mouth, sweating, dizziness), cognitive (difficulty concentrating, weakened memory) disorders observed on days 5-7 of Afobazol treatment. The maximum effect is achieved by the end of 4 weeks of treatment and remains in the post-therapy period on average 1-2 weeks.
Particularly shown is the use of the drug in people with mostly asthenic personality traits in the form of anxious suspicion, uncertainty, increased vulnerability and emotional lability, a tendency to emotional-stressful reactions. Afobazol is nontoxic.
Indications
Disturbing conditions in adults:
- generalized anxiety disorders, neurasthenia, adaptation disorders;
- in patients with various somatic (bronchial asthma, irritable bowel syndrome, SLE, IHD, arterial hypertension, arrhythmias), dermatological, oncological and other diseases;
- sleep disorders associated with anxiety;
- cardiopsychoneurosis;
- premenstrual tension syndrome;
- alcohol withdrawal syndrome;
- to facilitate the withdrawal from quitting smoking.
Forms of release
Tablets 5 mg and 10 mg.
Instructions for use and dosing regimen
The drug is administered orally after eating. Single dose is 10 mg; daily dose - 30 mg, divided into 3 doses during the day.
Duration of the course of the drug is 2-4 weeks.
If necessary, the daily dose of the drug can be increased to 60 mg, and the duration of treatment up to 3 months.
Side effect
- allergic reactions
- increased individual sensitivity.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- age to 18 years (for children, the drug is contraindicated);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy and lactation (breastfeeding).
Drug Interactions
With simultaneous use, Afobazol has no effect on the narcotic effect of ethanol (alcohol) and the hypnotic effect of thiopental.
With simultaneous use, Afobazol potentiates the anticonvulsant effect of carbamazepine.
With simultaneous use, Afobazol causes an increase in the anxiolytic effect of diazepam.
Analogues of the drug Afobazol
Structural analogs for the active substance:
- Afobazol GR;
- Neurophasol.
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