Phthalazole - instructions for use, reviews, analogs and formulations (tablets 500 mg) of the drug for the treatment of diarrhea in dysentery, colitis in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Phthalazole. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Phthalazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of phthalazole in the presence of existing structural analogs. Use for the treatment of diarrhea in dysentery, colitis, gastroenteritis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Phthalazole - antibacterial agent, a sulfonamide derivative. Has a wide spectrum of antimicrobial action. Phthalylsulfatiazole (active ingredient of the drug Ftalazol) is active against Gram-positive and Gram-negative microorganisms, incl. causative agents of intestinal infections. Poorly absorbed from the digestive tract. Acts mainly in the lumen of the intestine, where there is a gradual release of the sulfonamide part of the molecule.
The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.
Composition
Phtalylsulfatiazole + auxiliary substances.
Indications
- dysentery (acute and chronic in the stage of exacerbation);
- colitis;
- gastroenteritis;
- prevention of infectious complications in surgical interventions on the intestine.
Forms of release
Tablets 500 mg.
Instructions for use and dosage
Adults - 1-2 g every 4-6 hours for 5-7 days. Higher doses for adults inside: single dose - 2 g, daily - 7 g. Children under 3 years - 200 mg / kg per day in 3 doses for 7 days.Children older than 3 years - 400-750 mg (depending on age) 4 times a day.
Side effect
- Insufficiency of vitamins of group B (due to oppression of intestinal microflora);
- allergic reactions (rash, fever);
- agranulocytosis;
- aplastic anemia.
Systemic side effects, characteristic of sulfonamides, are rare due to insignificant absorption.
Contraindications
Hypersensitivity to phthalylsulfatiazole (including other sulfonamides).
Use in children
The application is possible according to the dosing regimen.
special instructions
If necessary, phthalazole is combined with sulfonamides or antibiotics that are well absorbed from the digestive tract.
Drug Interactions
The effect is enhanced by antibiotics and well-absorbed sulfonamides. Myelotoxic drugs enhance the manifestation of hematotoxicity of phthalylsulfatiazole.
Analogues of the drug Ftalazol
Structural analogs for the active substance:
- Phthalylsulfatiazole.
Analogues for the pharmacological group (remedies for the treatment of colitis):
- Azathioprine;
- Alginatol;
- Bifilysis;
- Hydrocortisone;
- Dexamethasone;
- Diprospan;
- Irmalax;
- Yogulact;
- Yogulact forte;
- Lactobacterin;
- Lemodus;
- Mesakol;
- Neonatrix;
- Pentasa;
- Prednisolone;
- Retinol;
- Salosinol;
- Salofalk;
- Triamcinolone;
- Urbazon;
- Fortecortin;
- Fortecortin Mono;
- Celeston;
- Eglonyl;
- Enterosan.
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