Epicurus - instructions for use, reviews, analogs and forms of release (capsules or tablets 30 mg) drugs for the treatment of stomach and duodenal ulcers in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Epicurus. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of doctors of specialists on the use of Epicurus in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Epicurus in the presence of existing structural analogues. Use to treat stomach and duodenal ulcers, including those associated with Helicobacter in adults, children,as well as during pregnancy and lactation.

Epicurus - antiulcer drug. Specific proton pump inhibitor (H-K-ATPase).

Metabolized in parietal cells of the gastric mucosa to active sulfonamide derivatives, which inhibit the sulfhydryl groups of H-K-ATPase. It blocks the final stage of synthesis of hydrochloric acid, reducing basal and stimulated secretion, regardless of the nature of the stimulus.

The use of the drug in a dose of 30 mg causes a decrease in the gastric secretion of hydrochloric acid by 80-97%. The inhibitory effect increases for 4 days. After discontinuation of the drug acidity is kept below 50% basal level for 39 hours, "ricochet" increase in secretion is not noted.

Secretory activity is restored 3-4 days after the end of the drug.

The drug has no effect on the motility of the gastrointestinal tract.

In patients with Zollinger-Ellison syndrome, the drug lasts longer.

Composition

Lansoprazole + auxiliary substances.

Pharmacokinetics

After taking the drug inside, Epicurus is well absorbed from the digestive tract. Bioavailability is 80%.Taking the drug simultaneously with food reduces absorption and bioavailability by 50%, but the inhibitory effect on gastric secretion remains the same. Actively biotransformed when "first pass" through the liver. The kidneys (in the form of metabolites) are derived from 14-23% of the dose, the rest - through the intestine.

Indications

• peptic ulcer of the stomach and duodenum;
• reflux esophagitis;
• erosive-ulcerative esophagitis;
• erosive and ulcerative lesions of the stomach and duodenum, associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs);
• stress ulcers;
• erosive and ulcerative lesions of the stomach and duodenum, associated with Helicobacter pylori (Helicobacter);
• Zollinger-Ellison syndrome.

Forms of release

Capsules 30 mg (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Capsules should be taken orally, swallowing whole, without chewing.

With duodenal ulcer in the phase of exacerbation appoint 30 mg per day for 2-4 weeks (in resistant cases - up to 60 mg per day).

With peptic ulcer of the stomach in the phase of exacerbation and with erosive-ulcerative esophagitis appoint 30-60 mg per day for 4-8 weeks.

With erosive and ulcerative lesions of the gastrointestinal tract caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs) - 30 mg per day for 4-8 weeks.

To eradicate Helicobacter pylori - 30 mg twice a day for 10-14 days in combination with antibiotic therapy.

For anti-relapse treatment of peptic ulcer of the stomach and duodenum - 30 mg per day.

For anti-relapse treatment of reflux esophagitis - 30 mg per day for a long time (up to 6 months).

In Zollinger-Ellison syndrome, the dose is individually selected to achieve a basal secretion level of less than 10 mmol / h.

Side effect

• headache;
• dizziness;
• drowsiness;
• depression;
• anxiety;
• decreased or increased appetite;
• nausea;
• stomach ache;
• diarrhea;
• constipation;
• ulcerative colitis;
• Candidiasis of the gastrointestinal tract;
• cough;
• pharyngitis;
• rhinitis;
• infection of the upper respiratory tract;
• influenza-like syndrome;
• thrombocytopenia (with hemorrhagic manifestations), anemia;
• skin rash;
• photosensitization;
• erythema multiforme;
• myalgia;
• alopecia.

Contraindications

• malignant neoplasms of the gastrointestinal tract;
• 1 trimester of pregnancy;
• lactation period (breastfeeding);
• children and adolescents under 18;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in the first trimester of pregnancy and during lactation (breastfeeding). In the 2 and 3 trimesters of pregnancy, the drug is administered with caution.

Application in elderly patients

With caution should be used in elderly patients.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

Before starting treatment with Epicurus, the possibility of malignant neoplasm in the upper gastrointestinal tract should be excluded, since taking the drug may mask symptoms and delay the correct diagnosis.

With caution should be used in patients with hepatic / renal failure, in the 2nd and 3rd trimester of pregnancy, in elderly patients.

Drug Interactions

Epicurus slows the excretion of drugs metabolized in the liver by microsomal oxidation (including diazepam, phenytoin, indirect anticoagulants).

Lansoprazole reduces the clearance of theophylline by 10%.

Lansoprazole slows down the pH-dependent absorption of drugs belonging to the weak acid groups and accelerates the pH-dependent absorption of drugs belonging to the groups of bases.

With simultaneous use of sucralfate reduces the bioavailability of Epicurus by 30%, so the interval between taking these drugs should be 30-40 minutes.

Antacids slow down and reduce the absorption of lansoprazole, so they should be prescribed 1 hour before or 1-2 hours after taking lansoprazole.

Analogues of the drug Epicurus

Structural analogs for the active substance:

• Acrylase;
• Lanzabel;
• Lanzap;
• Lansoptol;
• Lansoprazole;
• Lansofed;
• Lancid;
• Loenzar Sanovel.

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