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Ketoconazole - instructions for use, reviews, analogs and formulations (200 mg tablets, 400 mg vaginal suppositories, 2% cream or ointment, shampoo) drugs for the treatment of seborrhea (dandruff) and mycoses in adults, children and pregnancy. Composition

Ketoconazole - instructions for use, reviews, analogs and formulations (200 mg tablets, 400 mg vaginal suppositories, 2% cream or ointment, shampoo) drugs for the treatment of seborrhea (dandruff) and mycoses in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ketoconazole. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ketoconazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of ketoconazole in the presence of existing structural analogues. Use to treat seborrhea (dandruff) and mycosis (candidiasis and others) in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Ketoconazole - a synthetic antifungal agent of a wide spectrum of action for topical application.

 

The active substance is ketoconazole, an imidazole-dioxolane derivative. It has fungicidal and fungistatic action against dermatophytes: Trichophyton spp., Epidermophyton floccosum, Microsporum spp:, yeast and yeast-like fungi: Candida spp., Pityrosporum spp., Torulopsis, Cryptococcus spp.; dimorphic fungi and eumycetes. The drug is active against staphylococci and streptococci.

 

The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.

 

Composition

 

Ketoconazole + auxiliary substances.

 

Pharmacokinetics

 

Systemic absorption for intravaginal or external use is insignificant.

 

Indications

  • treatment of acute and chronic recurrent vaginal candidiasis;
  • prevention of fungal infections of the vagina with reduced resistance of the body and against treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina;
  • fungal infections of the digestive tract, genital organs, skin, hair (including seborrheic dermatitis), nails caused by sensitive pathogens;
  • mycoses (smooth skin dermatomycosis, inguinal epidermophytia, epidermophytia of hands and feet, skin candidiasis, pityriasis, seborrheic dermatitis);
  • prevention of fungal infections in patients with an increased risk of their development.

 

Forms of release

 

Tablets 200 mg.

 

Vaginal Candles 200 mg.

 

Cream 2%.

 

Ointment 2%.

 

Shampoo.

 

Instructions for use and how to use them

 

Pills

 

Inside, during meals, adults and children weighing more than 30 kg - 200 mg 1 time per day, with inefficiency - 400 mg once a day; Children with a body weight of 15 to 30 kg - 100 mg 1 time. When preventive use in patients with immunodeficiency, adults are prescribed 400 mg / day, children - 4-8 mg / kg / day.

 

Cream or ointment

 

External, cream or ointment is applied to the affected areas 1 time per day.

 

Shampoo

 

Locally - the shampoo is applied to the affected areas of the skin and hair, then after 3-5 minutes, rinse with water.

 

Candles for vaginal

 

Intravaginal. Preliminarily releasing the suppository from the contour pack, insert it deep into the vagina in the supine position on 1 suppository per day for 3-5 days depending on the course of the disease.

 

In chronic candidiasis apply to 1 suppository for 10 days.

 

Side effect

  • nausea, vomiting;
  • diarrhea;
  • headache;
  • dizziness;
  • sleep disorders;
  • paresthesia;
  • exanthema;
  • hair loss;
  • gynecomastia;
  • decreased libido;
  • oligospermia;
  • hives;
  • skin rash;
  • photophobia;
  • thrombocytopenia;
  • arthralgia;
  • fever.

 

Contraindications

  • marked violations of the liver and kidneys;
  • pregnancy;
  • lactation;
  • children under 12 years of age (safety and efficacy not established);
  • hypersensitivity to ketoconazole.

 

Application in pregnancy and lactation

 

Contraindicated in pregnancy and lactation.

 

Use in children

 

Contraindicated in children under 12 years. Use with caution in children aged 12 to 18 years.

 

special instructions

 

When oral administration is necessary to regularly monitor the picture of peripheral blood, the functional state of the liver and kidneys. If glucocorticosteroids (SCS) were used to treat skin lesions, then ketoconazole should be prescribed no earlier than 2 weeks later.

 

Simultaneous treatment of the sexual partner is recommended to reduce the risk of recurrence of the disease.

 

The use of candles can reduce the reliability of mechanical contraception (latex-containing condoms and vaginal diaphragms).

 

Drug Interactions

 

With the simultaneous use of ketoconazole with rifampicin and isoniazid, there is a decrease in the concentration of ketoconazole in the blood plasma.

 

With the simultaneous use of ketoconazole with cyclosporine, indirect anticoagulants and methylprednisolone, it is possible to increase their concentrations in the blood plasma.

 

Analogues of the drug Ketoconazole

 

Structural analogs for the active substance:

  • Dermazol;
  • Ketoconazole DS;
  • Ketoconazole Altpharm;
  • Livarol;
  • Mikanisal;
  • Mycosorrhal;
  • Mikoket;
  • Nizoral;
  • Oronazole;
  • Perch;
  • Sebosol;
  • Fungin;
  • Fungistab.

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Reviews (10):
Guests
Inga
Already tired of fighting with dandruff in the man's head. Like all decent citizens, before seeking medical help,we actively supported the cosmetic industry and bought in the department of household chemicals all varieties of shampoos that promised to cope with the problem. Naturally, not one of them improved the situation even a bit. And so, having finally reached the dermatologist, Ketoconazole shampoo was also appointed to them. It was this shampoo that could not be found quickly, it turns out that there is a deficit in our regions, but ketaconazole-containing shampoos in pharmacies are presented in excess. We stopped at the more or less popular - Nizoral, but the search for Ketoconazole did not stop. The effect became noticeable from the very first. For 3 washes, the problem was almost overcome. And Nizoral on it has ended, there packing as toy. And they found the same ketoconazole. He also enshrined the husband effect. Used 3 weeks. For a month now, we do not like to have a dandruff skin. Everything turned out so simple, it's a pity only time spent on buckets of stupid shampoos and money.
Guests
Natasha
I fought with dandruff and an itch of the head. To the doctor did not begin to address, thought, that itself I shall look for any agent, and here colleagues on work to me have advised to buy shampoo ketoconazole 2%. They washed their heads twice a week.The itch gradually disappeared with every wash, but the dandruff did not become smaller, according to my feelings.
Guests
Julia Voinskaya
Has handed over a smear and have found yeast. The doctor appointed candles, and I breastfeed. Tell me, is it worth it to put candles? I'm worried about the baby. Thank you.
Administrators
admin
Julia Voinskaya, Use of candles Ketoconazole is absolutely contraindicated in the first trimester of pregnancy. And relatively in the 2nd and 3rd trimester of pregnancy, as well as with lactation. In the latter case, all treatment is at the discretion of your treating doctor, since only he can determine whether you need to be treated with ketoconazole during breastfeeding or not. If it is necessary and there is no choice - treatment is justified.
Guests
Dimitry
After the first washing of the head with 2% cream, dandruff significantly disappeared, before the itch gave no peace. I searched for such a tool for a long time, tried everything, but this is exactly what I was looking for.
Guests
Julia Alexeevna
Good afternoon! Can I use Ketoconazole with hand eczema?
Administrators
admin
Julia Alexeevna, It is not necessary. Eczema is based on allergic mechanisms, not infectious or fungal in nature, so the use of ketoconazole in this disease is not appropriate. If there is a combined fungal lesion of the skin, then the fungus must be treated, including this drug, and clean eczema - no.
Guests
Anastasia Vladimirovna
Hello. Can I use ketoconazole in a pityriasis? Very large area (all back and chest). If so, how quickly will it pass?
Visitors
Ahactasia
Good afternoon. I have extensive scaly lichen. How quickly can ketoconazole help me?
Administrators
admin
Anastasia Vladimirovna, Yes, pityriasis is well treatable with Ketoconazole. It is also effective to combine antifungal drugs inside and external forms (ointments, shampoos) for the quickest onset of the effect. The duration of treatment depends on the area and intensity of skin lesions fungus.Pigmentation will take even longer. Refer for a specific dosage of ketoconazole or another antifungal agent to the dermatologist.

Ahactasia it's the same Anastasia Vladimirovna from the question above, Apply better to a specialist, a good dermatologist, to diagnose your disease, because skin diseases are similar to each other, and you have an otarian dystonia in one question, in another one already scaly. Making diagnoses on the Internet is an ungrateful occupation and such treatment will only make you worse. Methods of treating psoriasis with antifungal drugs are unknown to me, due to the scientifically unproven effectiveness of this group of drugs in case of scaly lichen.

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