Siofor - instructions for use, analogs, reviews and release forms (tablets 500 mg, 850 mg and 1000 mg) of the drug for the treatment of type 2 diabetes and associated obesity (for weight loss) in adults, children and pregnancy

In this article, you can read the instructions for using the drug Siofor. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Siofor in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Siofor analogues in the presence of existing structural analogs. Use for the treatment of type 2 diabetes and associated obesity (for weight loss) in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Siofor - a hypoglycemic agent from the biguanide group. Provides a reduction in both basal and postprandial concentrations of glucose in the blood. Does not stimulate the secretion of insulin and therefore does not lead to hypoglycemia. The effect of Metformin (the active substance of the preparation Siofor) is probably based on the following mechanisms:

• decrease in glucose production in the liver due to oppression of gluconeogenesis and glycogenolysis;
• increase the sensitivity of muscles to insulin and, consequently, improve glucose uptake on the periphery and its utilization;
• oppression of glucose absorption in the intestine.

Siofor by its action on glycogen synthetase stimulates intracellular synthesis of glycogen. Increases the transport capacity of all known to date membrane transport proteins of glucose.

Regardless of the effect on blood glucose levels, it has a beneficial effect on lipid metabolism, leading to a decrease in total cholesterol, low-density cholesterol and triglycerides.

Composition

Metformin hydrochloride + excipients.

Pharmacokinetics

When eating, the intake decreases and slightly slows down. Absolute bioavailability in healthy patients is approximately 50-60%.Virtually does not bind to plasma proteins. It is excreted unchanged in the urine.

Indications

• type 2 diabetes mellitus (non-insulin-dependent), especially when combined with obesity when diet therapy is ineffective.

Forms of release

Tablets coated with 500 mg, 850 mg and 1000 mg.

Instructions for use and reception scheme

The dose of the drug is set individually depending on the level of glucose in the blood. Therapy should be carried out with a gradual increase in dose, starting with 0.5-1 g (1-2 tablets) of Siofor 500 or 850 mg (1 tablet) of Siofor 850. Then, depending on the level of glucose, in the blood, the dose of the drug is increased at an interval of 1 week to an average daily dose of 1.5 g (3 tablets) of Siofor 500 or 1.7 g (2 tablets) of Siofor 850. The maximum daily dose of Siofor 500 is 3 g (6 tablets), Siofor 850 - 2.55 g (3 tablets) .

The average daily dose of Siofor 1000 is 2 g (2 tablets). The maximum daily dose of Siofor 1000 is 3 g (3 tablets).

The drug should be taken during meals, without chewing, squeezed with enough liquid.

If the daily dose of the drug is more than 1 tablet, it should be divided into 2-3 doses. The duration of use of Siofor is determined by the doctor.

The missed drug intake should not be compensated by a single intake of a correspondingly larger number of tablets.

Due to the increased risk of lactic acidosis, the dose of the drug should be reduced in case of severe metabolic disorders.

Side effect

• nausea, vomiting;
• metallic taste in the mouth;
• lack of appetite;
• diarrhea;
• flatulence;
• stomach ache;
• in single cases (with drug overdose, in the presence of diseases in which the use of the drug is contraindicated, with alcoholism) lactic acidosis may develop (requires discontinuation of treatment);
• with prolonged treatment may develop hypovitaminosis B12 (impaired absorption);
• megaloblastic anemia;
• hypoglycemia (with a dosing regimen);
• skin rash.

Contraindications

• diabetes mellitus type 1;
• complete cessation of insulin secretion in the body with diabetes mellitus type 2;
• diabetic ketoacidosis, diabetic precoma, coma;
• impaired liver and / or kidney function;
• myocardial infarction;
• cardiovascular failure;
• dehydration;
• severe lung diseases with respiratory failure;
• severe infectious diseases;
• surgery, trauma;
• catabolic states (states with enhanced decay processes, for example, in tumor diseases);
• hypoxic conditions;
• chronic alcoholism;
• laktatsidoz (including in the anamnesis);
• pregnancy;
• lactation (breastfeeding);
• adherence to a diet with a caloric restriction of food (less than 1000 kcal per day);
• childhood;
• application within 48 hours and less before and within 48 hours after carrying out radioisotope or X-ray studies with the introduction of iodine-containing contrast medium (Siofor 1000);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

special instructions

Before prescribing the drug, and every 6 months, it is necessary to monitor liver and kidney function.

It is necessary to monitor the level of lactate in the blood at least 2 times a year.

The course of treatment with Siofor 500 and Siofor 850 should be replaced with other hypoglycemic drugs (for example, insulin) 2 days before the X-ray examination with intravenous iodine-containing contrast agents,as well as 2 days before the operation under general anesthesia, and continue this therapy for another 2 days after the examination or after the operation.

When combined therapy with sulfonylurea derivatives, careful monitoring of blood glucose levels is necessary.

Impact on the ability to drive vehicles and manage mechanisms

When using Siofor, it is not recommended to engage in activities requiring concentration of attention and rapid psychomotor reactions because of the risk of developing hypoglycemia.

Drug Interactions

When used simultaneously with sulfonylurea derivatives, acarbose, insulin, non-steroidal anti-inflammatory drugs (NSAIDs), MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-adrenoblockers, hypoglycemic effect of Siofor can be increased.

When used simultaneously with glucocorticosteroids (GCS), oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormones, phenothiazine derivatives, nicotinic acid derivatives, hypoglycemic action of Siofor can decrease.

Siofor can weaken the effect of indirect anticoagulants.

With simultaneous use with ethanol (alcohol), the risk of lactic acidosis increases.

Pharmacokinetic interaction

Nifedipine increases the absorption and level of metformin in the blood plasma, prolongs its excretion.

Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, vancomycin), secreted in the tubules, compete for tubular transport system and long-term therapy can increase the concentration of metformin in the plasma.

Cimetidine slows the excretion of Siofor, which increases the risk of developing lactic acidosis.

Analogues of the drug Siofor

Structural analogs for the active substance:

• Bagomet;
• Glicon;
• Gliminfor;
• Gliiformin;
• Glucophage;
• Glucophage Long;
• Langerin;
• Metadiene;
• Methospanin;
• Metohamma 1000;
• Metohamma 500;
• Metohamma 850;
• Metformin;
• Metformin hydrochloride;
• Nova Met;
• Novoformin;
• Siofor 1000;
• Siofor 500;
• Siofor 850;
• Sofamet;
• Formethine;
• Formin Pliva.

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