Tinidazole - instructions for use, reviews, analogs and formulations (tablets 500 mg) of the drug for the treatment of giardiasis, trichomoniasis and amoebiasis in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Tinidazole. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tinidazole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tinidazole in the presence of existing structural analogues. Use for the treatment of giardiasis, trichomoniasis and amoebiasis in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Tinidazole antiprotozoal agent with antibacterial action. The mechanism of action is due to the inhibition of synthesis and damage to the DNA structure of pathogens.

It is active against Trichomonas vaginalis (trichomonas), Entamoeba histolytica, Lamblia intestinalis (Giardia). Has a bactericidal effect against the following anaerobic bacteria: Bacteroides spp. (Including Bacteroides fragilis, Bacteroides melaninogenicus), Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp.

Composition

Tinidazole + auxiliary substances.

Pharmacokinetics

Tinidazole has a high degree of absorption, bioavailability is about 100%. Binding to plasma proteins - 12%. Penetrates through the blood-brain barrier (GEB) and the placental barrier. It is excreted in breast milk for 72 hours after ingestion. It is metabolized in the liver to produce pharmacologically active hydroxylated derivatives which inhibit the growth of anaerobic microorganisms, and can enhance the effect of tinidazole. 50% excreted in the bile, kidneys displayed 25% (unchanged) and 12% (as metabolites) due to reabsorption in the renal tubules.

Indications

• trichomoniasis;
• giardiasis;
• amebiasis (including hepatic form);
• infections caused by anaerobic bacteria;
• mixed aerobic-anaerobic infections (in combination with antibiotics);
• eradication of Helicobacter pylori (in combination with bismuth preparations and antibiotics);
• prevention of postoperative anaerobic infections.

Forms of release

The tablets covered with a cover of 500 mg.

Instructions for use and dosing regimen

Individual. Adults - 1.5-2 g once a day; children (except for the prevention of postoperative anaerobic infections) - 50-75 mg / kg once a day. The duration of treatment is determined by the clinical situation and can be 1-10 days.

Side effect

• anorexia;
• dryness of the oral mucosa;
• metallic taste in the mouth;
• nausea, vomiting;
• diarrhea;
• headache;
• dizziness;
• fatigue;
• violation of coordination of movements (including locomotor ataxia);
• dysarthria;
• peripheral neuropathy;
• convulsions;
• weakness;
• hives;
• itching;
• skin rash;
• angioedema;
• transient leukopenia.

Contraindications

• organic diseases of the central nervous system;
• disorders of hematopoiesis;
• 1 trimester of pregnancy;
• lactation (breastfeeding);
• hypersensitivity to tinidazole or other 5-nitroimidazole derivatives.

Application in pregnancy and lactation

Contraindicated in the first trimester of pregnancy. Use in the 2nd and 3rd trimesters is only possible if the intended benefit to the mother exceeds the potential risk to the fetus.

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved. Tinidazole is given in breast milk for 72 hours after ingestion.

Use in children

For the prevention of postoperative anaerobic infections, doses for children under 12 years of age have not been established.

special instructions

In the treatment of trichomoniasis, simultaneous treatment of both partners should be carried out.

When there are side effects from the CNS, tinidazole should be discarded.

During the treatment should refrain from drinking alcohol.

When applying tinidazole, dark staining of urine is observed.

If treatment lasts more than 6 days, regular monitoring of the picture of peripheral blood should be carried out.

For the prevention of postoperative anaerobic infections, doses for children under 12 years of age have not been established.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, patients should refrain from engaging in potentially hazardous activities requiring increased attention and high speed of psychomotor reactions.

Drug Interactions

With the simultaneous use with ethanol (alcohol), one can not exclude the development of a disulfiram-like effect.

Analogues of the drug Tinidazole

Structural analogs for the active substance:

• Vero Tinidazole;
• Tiniba;
• Tinidazole Acry;
• Fazizhin.

Analogues on the pharmacological group (funds for the treatment of trichomoniasis).

• Atrikan 250;
• Betadine;
• Gairo;
• Genferon;
• Ghine Lotrimin;
• Dazolik;
• Yodoxide;
• Clion;
• Clotrimazole;
• McMiore;
• Metrogil;
• Metronidazole;
• Miramistin;
• Naxojin;
• Neo Penotran;
• Orvagil;
• Ornisid;
• Ornisid Forte;
• Safotsid;
• SolkoTrichovak;
• Terzhinan;
• Tiberal;
• Trichopol;
• Flagel.

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