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Glyukofazh - instructions for use, analogs, reviews and release forms (tablets 500 mg, 750 mg, 850 mg and 1000 mg, Long) drug for the treatment of type 2 diabetes and weight loss in adults, children and pregnancy. Composition and alcohol

Glyukofazh - instructions for use, analogs, reviews and release forms (tablets 500 mg, 750 mg, 850 mg and 1000 mg, Long) drug for the treatment of type 2 diabetes and weight loss in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Glucophage. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Glucophage in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Glucophage in the presence of existing structural analogues. Use for the treatment of type 2 diabetes in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

 

Glucophage - oral hypoglycemic agent from the biguanide group.

 

Glucophage reduces hyperglycemia, without leading to the development of hypoglycemia. Unlike derivatives of sulfonylurea, it does not stimulate insulin secretion and does not have hypoglycemic action in healthy individuals.

 

Increases the sensitivity of peripheral receptors to insulin and the utilization of glucose by cells. Reduces the production of glucose by the liver by inhibiting gluconeogenesis and glycogenolysis. Delays the absorption of glucose in the intestine.

 

Metformin (the active substance of the drug Glucophage) stimulates the synthesis of glycogen, affecting glycogen synthetase. Increases the transport capacity of all types of membrane glucose transporters.

 

In addition, it has a beneficial effect on lipid metabolism: it reduces the content of total cholesterol, LDL and TG.

 

Against the background of taking Glucophage the body weight of the patient either remains stable or moderately decreases.

 

Composition

 

Metformin hydrochloride + excipients.

 

Pharmacokinetics

 

After taking the drug inside Glukofazh is completely absorbed from the digestive tract. With simultaneous intake of food, absorption of Metformin is reduced and delayed. Absolute bioavailability is 50-60%.Metformin is quickly distributed into the tissues of the body. Virtually does not bind to plasma proteins. To a very small extent, it is metabolized and excreted by the kidneys.

 

Indications

 

Diabetes mellitus type 2, especially in patients with obesity, with ineffectiveness of diet and exercise:

  • in adults as a monotherapy or in combination with other oral hypoglycemic drugs, or with insulin;
  • in children aged 10 years and older as a monotherapy or in combination.

 

Forms of release

 

Tablets coated with 500 mg, 850 mg and 1000 mg.

 

Long-acting tablets 500 mg and 750 mg (Long).

 

Instructions for use and reception scheme

 

The drug is taken orally.

 

Pills

 

Adults

 

Monotherapy and combination therapy with other oral hypoglycemic agents

 

The usual initial dose is 500 mg or 850 mg 2-3 times a day after or during meals. A further gradual increase in the dose is possible depending on the concentration of glucose in the blood.

 

The maintenance dose of the drug is usually 1500-2000 mg per day. To reduce side effects from the gastrointestinal tract, the daily dose should be divided into 2-3 doses.The maximum dose is 3000 mg per day, divided into 3 doses.

 

A slow increase in dosage can help improve gastrointestinal tolerance.

 

Patients receiving metformin at doses of 2-3 g per day can be transferred to receive Glucophage 1000 mg. The maximum recommended dose is 3000 mg per day, divided into 3 doses.

 

In case of planning the transition from taking another hypoglycemic drug: it is necessary to stop taking another drug and start taking Glucophage in the dose indicated above.

 

Combination with insulin

 

To achieve better control of glucose in the blood, metformin and insulin can be used as a combination therapy. The usual initial dose of Glucophage is 500 mg or 850 mg 2-3 times a day, while the insulin dose is selected based on the concentration of glucose in the blood.

 

Children and teens

 

In children aged 10 years and older, Glucophage can be used both as monotherapy and in combination with insulin. The usual initial dose is 500 mg or 850 mg once a day after or during a meal. After 10-15 days, the dose should be adjusted based on the blood glucose concentration.The maximum daily dose is 2000 mg, divided into 2-3 doses.

 

Elderly patients

 

Because of a possible reduction in renal function, the dose of metformin should be selected under regular monitoring of renal function (determine the creatinine content in serum at least 2-4 times per year).

 

Glucophage should be taken daily, without interruption. In the event of discontinuation of treatment, the patient should inform the physician about this.

 

Long tablets

 

The drug is taken orally. Tablets are swallowed whole, not liquid, squeezed with a small amount of water.

 

Long-acting tablets 500 mg

 

The drug is taken during dinner (1 time per day) or during breakfast and dinner (2 times a day). Tablets should be taken only during meals.

 

The dose of the drug is determined based on the glucose content in the blood plasma.

 

Monotherapy and combination therapy in combination with other hypoglycemic agents

 

The drug Glucophage Long is prescribed in an initial dose of 500 mg (1 tablet) 1 time per day during dinner.

 

When switching from Glucophage (tablets with the usual release of the active substance), the initial dose of Glucophage Long should be equal to the daily dose of Glucophage.

 

Dose titration: depending on the glucose level in the blood plasma, every 10-15 days the dose is slowly increased by 500 mg to the maximum daily dose.

 

The maximum daily dose of Glucophage Long is 2 g (4 tablets) once a day during dinner.

 

If glucose control is not achieved at the maximum daily dose taken once a day, then you can consider the possibility of dividing this dose into several doses per day as follows: 2 tablets at breakfast time and 2 tablets at dinner time.

 

When Glucophage Long is used together with insulin, the usual initial dose of the drug is 500 mg (1 tablet) once a day, and the insulin dose is selected based on the results of measuring the glucose content in the blood plasma.

 

Glucophage Long should be taken daily, without interruption. In the event of discontinuation of treatment, the patient should inform the physician about this.

 

If the next dose is missed, the next dose should be taken at the usual time. You can not double the dose of the drug.

 

Long-acting tablets 750 mg

 

The drug is taken during or after dinner (1 time per day).

 

Monotherapy and combination therapy in combination with other hypoglycemic agents

 

The initial dose is, as a rule, 1 tablet 1 time per day.

 

After 10-15 days of treatment, the dose should be adjusted based on the results of measuring blood glucose. Slow increase in dose helps reduce side effects from the digestive tract.

 

The recommended dose of the drug is 1.5 g (2 tablets) once a day. If the recommended dose does not manage to achieve adequate control of glycemia, it is possible to increase the dose to a maximum of 2.25 g (3 tablets) once a day.

 

If adequate glycemic control is not achieved when taking 3 tablets 750 mg once a day, then it is possible to switch to a metformin preparation with the usual release of the active substance with a maximum daily dose of 3 g.

 

For patients already receiving metformin tablets, the initial dose of Glucophage Long should be equivalent to the daily dose of tablets with normal release. Patients taking metformin in the form of tablets with a normal release in a dose exceeding 2 g do not recommend switching to Glucophage Long.

 

In case of planning a transition from another hypoglycemic agent: it is necessary to stop taking another drug and start taking Glucophage Long in the dose indicated above.

 

Combination with insulin

 

To achieve better control of blood glucose concentrations, metformin and insulin can be used as a combination therapy. The usual initial dose of Glucophage Long is 1 750 mg tablet once a day during supper, while the insulin dose is selected based on the results of measuring the glucose level in the blood.

 

Special patient groups

 

In elderly patients and patients with reduced renal function, the dose is adjusted based on the evaluation of renal function, which must be performed regularly at least 2 times per year.

 

The drug Glucophage Long should not be used in children and adolescents under 18 years due to lack of application data.

 

Side effect

  • lactic acidosis;
  • with prolonged use, it is possible to reduce absorption of vitamin B12;
  • a taste disorder;
  • nausea, vomiting;
  • diarrhea;
  • stomach ache;
  • lack of appetite;
  • erythema;
  • itching;
  • rash;
  • violation of liver function;
  • hepatitis.

 

After canceling Metformin, the side reactions completely disappear.

 

Contraindications

  • diabetic ketoacidosis;
  • diabetic precoma;
  • diabetic coma;
  • renal dysfunction (KK <60 ml / min);
  • kidney failure;
  • acute conditions in which there is a risk of kidney dysfunction: dehydration, (with diarrhea, vomiting), severe infectious diseases, conditions, shock;
  • clinical manifestations of acute and chronic diseases that can lead to the development of tissue hypoxia (including respiratory failure, heart failure, acute myocardial infarction);
  • extensive surgery and trauma (when carrying out insulin therapy);
  • liver failure;
  • impaired liver function;
  • chronic alcoholism, acute ethanol poisoning;
  • laktatsidoz (including in the anamnesis);
  • period not less than 48 hours before and within 48 hours after radioisotope or X-ray studies with the introduction of iodine-containing contrast agent;
  • adherence to a hypocaloric diet (<1000 kcal per day);
  • pregnancy;
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The drug is contraindicated for use in pregnancy.

 

Decompensated diabetes mellitus during pregnancy is associated with an increased risk of congenital malformations and perinatal mortality.A limited amount of evidence suggests that the use of metformin in pregnant women does not increase the risk of congenital malformations in children.

 

When planning pregnancy, and also in case of pregnancy on the background of taking metformin, the drug should be canceled, and insulin therapy is prescribed. It is necessary to maintain the level of glucose in the blood plasma at the level closest to the norm in order to reduce the risk of fetal malformations.

 

Metformin is excreted in breast milk. Side effects in newborns with breastfeeding against metformin were not observed. However, due to the limited amount of data, the use of the drug in breastfeeding is not recommended. The decision to stop breastfeeding should be taken in consideration of the benefits of breastfeeding and the potential risk of side effects in the child.

 

Use in children

 

The diagnosis of Type 2 diabetes mellitus should be confirmed before the start of treatment with metformin.

 

In clinical studies lasting 1 year, it was shown that metformin does not affect growth and puberty.However, in view of the lack of long-term data, careful monitoring of the subsequent influence of metformin on these parameters in children, especially during puberty, is recommended. The most careful control is needed for children aged 10-12 years.

 

Published data, postmarketing data, as well as data from controlled clinical trials in a limited pediatric population in the 10 to 16 age group, show that the side effects in children are similar in nature and severity to those in adult patients.

 

special instructions

 

Lactacidosis

 

Lactacidosis is a rare but severe (high mortality in the absence of emergency treatment) complication that may occur due to the cumulation of metformin. Cases of lactic acidosis with metformin were mainly in diabetic patients with severe renal failure.

 

Other associated risk factors, such as decompensated diabetes mellitus, ketosis, prolonged fasting, alcoholism, liver failure and any condition associated with severe hypoxia, should be considered. This can help reduce the incidence of lactic acidosis.

 

The risk of developing lactic acidosis when nonspecific signs appear, such as muscle cramps, accompanied by dyspeptic symptoms, abdominal pain and severe asthenia, should be considered. Lactacidosis is characterized by acidotic dyspnea, abdominal pain and hypothermia followed by coma.

 

Diagnostic laboratory indicators are a decrease in blood pH (less than 7.25), a lactate content in the blood plasma above 5 mmol / l, an increased anion gap and a lactate / pyruvate ratio. If you suspect a metabolic acidosis, stop taking the medication and consult a doctor immediately.

 

Surgical operations

 

The use of Glucophage should be discontinued 48 hours before planned surgical operations and can be continued no earlier than 48 hours after, provided that during the examination the renal function was found to be normal.

 

Kidney function

 

Since metformin is excreted by the kidneys, before starting treatment and regularly thereafter, it is necessary to determine QC: at least once a year in patients with normal renal function, and 2-4 times a year in elderly patients, as well as in patients with CC at the lower border of norm.

 

Special caution should be exercised in cases of possible impairment of kidney function in elderly patients, with the simultaneous use of antihypertensive drugs, diuretics or NSAIDs.

 

Other Precautions

 

Patients are encouraged to continue to follow a diet with an even intake of carbohydrates throughout the day. Patients with excessive body weight are recommended to continue to observe a hypocaloric diet (but not less than 1000 kcal per day).

 

It is recommended that regular laboratory tests be performed on a regular basis to control diabetes mellitus.

 

Metformin with monotherapy does not cause hypoglycemia, but it is recommended to use caution when used in combination with insulin or other hypoglycemic agents (including sulfonylurea derivatives, repaglinide).

 

Impact on the ability to drive vehicles and manage mechanisms

 

Monotherapy with Glucophage does not cause hypoglycemia, so it does not affect the ability to drive vehicles and mechanisms. Nevertheless, patients should be cautioned about the risk of hypoglycemia when using metformin in combination with other hypoglycemic drugs (including those with sulfonylureas, insulin, repaglinide).

 

Drug Interactions

 

Contraindicated combinations

 

Iodine-containing radiopaque means: on the background of functional renal failure in diabetic patients, a radiological study using iodine-containing radiocontrast agents can cause the development of lactic acidosis. Treatment with Glucophage should be canceled depending on the function of the kidneys 48 hours before or at the time of radiologic examination using iodine-containing radiopaque means and do not resume earlier 48 hours after, provided that during the examination the renal function was found to be normal.

 

Unrecommended combinations

 

Alcohol: with acute alcohol intoxication, the risk of developing lactic acidosis increases, especially in the case of:

  • malnutrition, low-calorie diet;
  • hepatic insufficiency.

 

During taking the drug, you should avoid drinking alcohol and drugs containing ethanol.

 

Combinations that require caution

 

It is not recommended simultaneous reception of danazol in order to avoid hyperglycemic action of the latter.If necessary, treatment with danazol and after discontinuation of the latter requires a correction of the dose of Glucophage drug under the control of the concentration of glucose in the blood.

 

Chlorpromazine when taken in high doses (100 mg per day) increases the concentration of glucose in the blood, reducing the release of insulin. When treating with neuroleptics and after stopping the intake of the latter, correction of the dose of the drug under the control of the concentration of glucose in the blood is required.

 

Glucocorticosteroids (GCS) for systemic and topical administration reduce glucose tolerance, increase the concentration of glucose in the blood, sometimes causing ketosis. In the treatment of GCS and after discontinuation of the latter, correction of the dose of Glucophage is required under the control of the glucose concentration in the blood.

 

Simultaneous reception of "loop" diuretics can lead to the development of lactic acidosis due to possible functional renal failure. Do not prescribe Glucophage if the SC is less than 60 ml / min.

 

Beta2-adrenomimetics in the form of injections increase the concentration of glucose in the blood due to stimulation of beta2-adrenoreceptors. In this case, it is necessary to monitor the concentration of glucose in the blood.If necessary, it is recommended to prescribe insulin.

 

With the simultaneous use of the above medicines, more frequent monitoring of the glucose level in the blood may be required, especially at the beginning of the treatment. If necessary, the dose of metformin can be adjusted during treatment and after its termination.

 

ACE inhibitors and other antihypertensive drugs can reduce the concentration of glucose in the blood. If necessary, the dose of metformin should be adjusted.

 

With the simultaneous use of the drug Glucophage with derivatives of sulfonylurea, insulin, acarbose, salicylates may develop hypoglycemia.

 

Nifedipine increases the absorption of metformin.

 

Analogues of the drug Glucophage

 

Structural analogs for the active substance:

  • Bagomet;
  • Glicon;
  • Gliminfor;
  • Gliiformin;
  • Glucophage Long;
  • Langerin;
  • Metadiene;
  • Methospanin;
  • Metohamma 1000;
  • Metohamma 500;
  • Metohamma 850;
  • Metformin;
  • Metformin hydrochloride;
  • Nova Met;
  • Novoformin;
  • Siofor 1000;
  • Siofor 500;
  • Siofor 850;
  • Sofamet;
  • Formethine;
  • Formin Pliva.

Similar medicines:

Other medicines:
Reviews (52):
Guests
Anyuta P.
My grandmother has diabetes mellitus. The level of sugar in the blood usually fluctuates between 12-17. How many different drugs, designed to reduce these huge numbers, people's funds were accepted - all and not to remember. But the sense of them is not enough and the result is unstable.

Recently, in our district clinic, where granny is observed, the endocrinologist has changed. She was the one who prescribed Glucophage. Take 1 tablet 2 times a day in a dosage of 500 mg. To our great surprise, Glucophage did not cause any side effects. At all previous agents something yes was shown, that a nausea, a diarrhea, that an eruption, that vomiting. The sugar level gradually decreased to 7-9, not the norm, of course, but much better than it was. Drinking the drug for six months, the result is kept. Another plus is the loss of extra 2 kg, although I can not say that my grandmother is fat, but she is definitely not.

Glucophage is happy, this is the only remedy that helped smoothly and steadily reduce blood sugar levels.Now he is thinking of switching to a glucocarj of a prolonged action in order to take it once a day and not to worry that he will miss reception because of sclerosis.
Guests
galena
Glucophage I take 2 weeks. There were abdominal pains, but passed, diarrhea also passed. Sugar from 8.9 was on an empty stomach 6.6, 3 hours after eating 6.3. I drink 850 1 time, but began to itch. So I do not know what to do?
Administrators
admin
galena, Skin itching is a side effect that is regulated by the patient. If he gives you great anxiety, then you need to consult a doctor about changing the treatment schedule, if it is insignificant (the so-called scratching), then you can continue taking Glucophage further. Naturally, if the itching is intense or there are red spots of an allergic nature, then the treatment regimen must be changed, as the risk of allergic reactions, including those dangerous for life, is great.
Guests
Inessa, 40 years old
A good preparation is glucophage. The truth after its reception I have grown thin for 10 kg (before this neither diet, nor in general helped or assisted nothing, there was an endocrine obesity), but also has started to feel the liver.So without consulting a doctor such a strong remedy I would not advise taking. Health can fly.
Guests
NATALIA 43 YEARS
I take the drug Glucophage long 750 for 1 tablet 2 times a day. In the morning and in the evening. I started taking it as directed by a doctor in May. Sugar fell from 9 to 5.5-6 units. And most importantly - I lost 10 kg in weight since May. I try not to eat flour and sweet. In principle, I like the drug. No side effects did not notice.
Guests
Valentina 57 years old
The endocrinologist has appointed or nominated to drink Gljukofazh 1000 since June, 2015. Saw it 4 months twice a day. Sugar fell from 7.2 to 5.1 and lower, diet, plus walking. Weight decreased by 10 kg. In October, I stopped drinking it and sugar was always on the glucometer in the norm. One of these days has handed over a blood on glycosylated sugar - has shown 6 units. I again start to drink glucofage. For this time in weight did not add, the physical load did not stop, I follow the diet. I only have doubts about the dose of the appointed glucofage. There was no puncture.
Administrators
admin
Valentina 57 years old, 2000 mg (two 1000 mg tablets), the normal maintenance dosage of glucosulphate, and it is written in the instructions. More than this dose should not be taken.
Guests
Anna 34 years old
To me the endocrinologist has diagnosed a diabetes of 2 types. I prescribed Glucophage Long 750 mg to drink 1 time per day for 2 tablets at dinner. There was an itch on the arms and legs, I did not notice a decrease in weight from the tablets, the sugar is slightly reduced from 7.7 to 6.6 (per year). I told the endocrinologist about the itching on the body, but he said that it was definitely not because of the pills, because Glucophage Long tablets are tested and many years work with them.
Administrators
admin
Anna 34 years old, Skin itching and other allergic manifestations can give any medicine, so your doctor is wrong. I would change the specialist and consulted with another endocrinologist for changes in the treatment regimen.
Guests
Nataliya 43 years old
The doctor-nutritionist prescribed to me Glukofazh Long for weight loss and normalization of metabolism (blood tests revealed a violation of girorolipidnogo exchange).The hepatologist diagnosed fatty liver hepatosis and also said that this drug will help the liver and lower cholesterol. I took the drug two months once a day, evenings during dinner. In the first week there was severe diarrhea in the evening, but then everything went away. Sometimes diarrhea resumed, periodically, but not permanently. During the reception of the tablets I felt very good: lightness, completely disappeared discomfort in the liver, decreased appetite, lost 2 kg, but I did not observe the diet and there were no special physical exertions. But there was a feeling that the volume of the body had gone, the stomach was smaller. By results of analyzes for 1,5 months sugar became 3,8, and was 5,5; cholesterol 6.1, and was 6.8. Has ceased to accept a preparation after visiting the endocrinologist in occasion of the control over application of a preparation for a thyroid gland. The doctor asked me if I'm afraid of diabetes after I cancel Glucophage. And she said that she does not recommend taking such a serious drug, but you need to exercise.
Guests
Robert.
My mother's nausea and vomiting from all drugs, she is already uncomfortable complaining that no drug (diabetes, metformin, syphor, glucophage), replaced by a doctor, after the complaints are not digested.Sugar in the morning from 6-7, after a meal to 11-15, it can be fidgety and can be worse on an empty stomach. We do not know what to do?
Administrators
admin
Robert.The drugs indicated in the question should not be assimilated, their task is to block the excessive absorption of sugars into the blood and remove this glucose from the body, including sometimes provoking unpleasant effects in the form of flatulence, diarrhea, but not vomiting. If the whole issue is an increased level of blood sugar when taking hypoglycemic drugs, then there is a subtle question, if oral preparations of the biguanide group do not work, you can try preparations of the urea group (Glibenclamide, Maninil, Diabeton and others), combining everything with a strict diet, if this does not help, the alternative may be insulin. Address to the endocrinologist for internal consultation.
Guests
Anna
A year ago, I was diagnosed with prediabetes. The doctor said that the reason is overweight, high cholesterol and metabolic disorders. Indeed, against the backdrop of menopause, I recovered very much, there was shortness of breath, pain in the back. Then here and prediabetes ...The doctor appointed me Glucophage. This is the only drug in Russia for treating this condition. It really helps, too. Analgeses have now been much improved - on sugar and cholesterol. The general condition has changed - no longer disturbed by shortness of breath, a constant decline in strength. She lost weight by nine kilograms. I continue to take the drug, plus follow the diet - this is a prerequisite for the appointment of glucose. I eat only lean meat, milk 1% or less. I follow the content of sugar in the products, etc. Even now I go to the pool now.
Administrators
admin
Anna, Glukofazh advertising you did not work. And, it should be noted, this is not the only drug for treating pre-diabetes. If I once again notice the attempts to advertise your medication in the comments under the guise of ordinary visitors - the moderation of the reviews for the drug will be significantly toughened, and all the visitors noted by such advertising will be banned and they will be forbidden to post reviews and ask questions in the Directory. For the first time a warning.
Administrators
admin
Visitor feedback Sergei moved to the required section:
In general, eat your glucose and drink pork. The result is zero, but as a snack will go.
Guests
Mazumi
The drug is good. At least he keeps sugar. Well, there is a small weight loss. A kilogram of three or four. I would like more, but as it is. The only thing that upsets is that Glucophage should be taken constantly. I tried to refuse, immediately sugar jumps up. One diet is not enough. And I would like - a course to drink and take a break at least some ...
Guests
Tatyana
The drug is good, but after taking 6 months. I had hives. It was treated at the allergist by preparations, problems with pressure and heart have begun. Now I'm being examined for these sores. To the endocrinologist yet did not go, since. there is no doctor in the clinic, I have to go to a paid doctor, and I already ate a financial resource for this month - I'm a pensioner. Glucophage I do not drink, sugar 7 units.
Visitors
NATALIE13
Hello. My mother donated blood to the sugar curve.Initially, the analysis showed 5.3, then after taking a glucose solution (300 grams), the result of the analysis was 7.5. The doctor said that there is no reason to believe that this is diabetes, but he can develop over time and prescribed Glucophage Long 500 g once a day. A month before, my mother gave the same analysis, the indices were normal. Also mum handed over the glycemic analysis of a blood, result-5,8. Do I need to take this medication with my mother? And for how long.
Guests
натальяЕ
Tell me, please, how does this drug affect the liver? I began to notice the pain, but did not exist before. I take Glucophage within a year.
Administrators
admin
NATALIE13It follows from the question that your mother is shown taking medications to eliminate impaired glucose tolerance (now the standard metformin group is Glucophage, Metformin, Siofor and other drugs). It's not diabetes, but it's somewhere close. Judging by the numbers of analyzes, your mother is in the first stages, when much is reversible. It is also shown to make ultrasound of the abdominal cavity organs (pay attention to the pancreas), donate blood to glycated hemoglobin (if this is not the case in your question "glycemic blood test").To search for the reason of possible infringements - in 90% of cases the reason lays in excess weight which also will demand updatings with delivery of age-necessary hormones and correction of a diet if necessary. They take hypoglycemic drugs for years, perhaps even for life, and questions about cancellation or change of therapy schemes in this case only through the treating endocrinologist.

натальяЕ, Influence is negative by the principle of one treat, the other is crippled. According to recent data of Americans, long-term use of metformin drugs may lead to single cases of hepatitis. So the appointment of Glucophage and other drugs with it should have a clear rationale. In your case, it is worth checking the liver (ultrasound, biochemistry of blood with the definition of liver enzymes) and consult with a doctor in person.
Guests
Elena Shatskaya
The papa was prescribed glucose 750 mg for 2 tablets at dinner. For 15 days, sugar from 11 units became 8 and slightly less, and the weight decreased by 6 kg. Observes the diet. Because of my stress, sugar began to gallop and weight grew. Have put prediabetes. The doctor prescribed the same medicine only 1 tablet for weight loss.Now they are allowed to recommend them to an endocrinologist in similar cases. All of health.
Guests
Olga
Saw a glucosephase 2 times 500 mg, kept poorly, although diet adhere, by evening sugar to 17 meals increased, increased the dose of 750 grams. 2 times morning to evening. In the evening, sugar before 11, I drank another 500 mg, now I switched to Glucophage Long, twice a day for 750 mornings - evening. The results are the same, in the evening. I drink 500 more. I decided not to drink at all. I do not think I'm getting a glucose at all. The liver, abdomen, from a long application the lower pressure hurts. Pain of the vessels of the legs, stomach ... I think all the fault is in it.
Guests
Elena
I drink Glucophage long 3 months of 2 tons (1500 mg) during dinner, so the doctor appointed to treat prediabetes. The result is 0. Sweet, I do not eat bread or eat, I do not eat at night. But the effect of the drug does not feel any. Weight, too, is not gone by a gram ...
Visitors
andrewkr
Good afternoon. My mother takes Glucophage Long, 2 500 mg tablets after dinner. The instructions say that metformin can not be combined with ethanol. About alcohol and even alcohol tinctures, valokordina, etc. understandably.Is it possible to eat sauerkraut, drink kefir, fermented baked milk, yogurt? As far as I know, in these products there is a very small amount of alcohol, which is formed in the process of fermentation.
Administrators
admin
andrewkr, These products contain trace amounts of alcohol that do not affect the metabolism of Glucophage Long medication and should not affect liver health. The liver is such an organ, it can react without alcohol to the drug taken, but this is a probability, as well as when taking any other medicine. Do not exaggerate the colors and soothe your mother, let her eat traditionally and in a balanced way, and if you have extra weight - then follow the prescribed diet.
Visitors
andrewkr
Thanks for the answer. Now, at least I will know that fermented products can be safely eat if you take metformin.
Guests
Tatyana
Hello. I was diagnosed with prediabetes. Glikirovany hemoglobin showed normal, the analysis of the finger showed the first time 8, two days later a repeat, showed 6.7.She went on a diet (not strict) and excluded sausages and pastry (I ignored them before), fried, sugar, honey a little bit with coffee, bread gray or rye, porridge (pyshenka, oat flakes, pearl barley, buckwheat), pork low-fat, chicken, boiled, stewed or in the oven. After a month, analysis 6.4. Can something be corrected in the diet and while do without pills? I heard, if you sit down on them, then always.
Administrators
admin
TatyanaOatmeal flakes clean, cereals are better whole-grain. Otherwise, you do everything right, but a month is not a term for diabetes, and glucose 8 can already testify to serious violations of carbohydrate metabolism. Glucophage, Metformin or similar drugs should be taken, gradually increasing the dosage to the recommended by the doctor, and if you do not lose your nourishment, it will be possible after 1-2 years to reach normal glucose values ​​and also gradually to cancel the tablets. Not always it turns out, but the raised sugar is not jokes and strongly harms to vessels and target organs.
Administrators
admin
Feedback from the site visitor Elena 64 moved to the required section:
Saw the glucofuge long - 1500 mg. 1 month by endocrinologist. Has grown thin for 7 kg, by-side actions has not noted (except for appreciable thirst). Intends to continue taking after the tests - glucose, creatinine and lactate in the blood plasma.
Guests
guests
At me from reception of a preparation - a dermal itch. Sugar, oddly enough, on the contrary, has risen. The condition did not improve. Sugar - 7.4. I follow a diet. I do not eat sweets. Alcohol I do not drink.
Visitors
oiika
Hello. Today was on reception at the endocrinologist in occasion of sharply increased shchitovidki. The doctor assigned me Glucophage Long 750 to 1 tab. at night to reduce weight. Sugar from a vein I have - 6, from a finger - 5, cholesterol for 7 years now it keeps on 6. But the weight is really big. But I have almost no change in my life for 30 years. So is it worth it to drink this medicine? Would not it be addictive? How then to stop his reception? Thankful in advance for advice or council.
Administrators
admin
oiika, Sugar at the limit of the norm, plus excess weight. It is necessary to pass a glucose tolerance test (when the blood is taken for glucose on an empty stomach, and then 2 hours after a hearty breakfast or a drunk concentrated glucose solution), after that it will be clear if you need Glucophage or you can do only a diet.
Guests
Marina is 45 years old.
Hello. The analysis showed sugar the first time 7.2, the second time 7.6. Have registered Gljukofazh 750 once after a supper. I take 2 weeks, sugar has not measured only 20 for analysis, but I'm worried about an upset in the morning and evening. The doctor says that it can not be, it's only constipation. Although the instructions are written. Tell me, what should I do to take or throw, or can I connect something from diarrhea? The diet I observe neither sugar nor flour or sweet, I lost 2kg of weight. And maybe this headache? Thanks in advance.
Administrators
admin
Marina is 45 years old., Metformin (Glucophage, Metformin, Siofor) preparations can cause diarrhea, fermentation in the intestines and other symptoms of dyspepsia.The fact is that doctors do not prescribe them correctly, stepwise with a gradual increase in the dose of the drug. If the desired dosage is 750 mg, then I would begin to administer the drug gradually, 500 mg for the first 2 weeks and only then 750 mg, strictly after meals or better at mealtime, or I would break the Glucophage intake for 2 500 mg meals (breakfast- lunch as the most carbohydrate meals), which can also help get rid of unpleasant symptoms. Headaches as side effects when taking Glucophage are uncharacteristic.
Visitors
Kalinka
Hello. Against the background of chemotherapy and tamoxifen treatment, fatty hepatosis was diagnosed. The liver is enlarged. Have appointed or nominated gljukofazh on 500 two times a day (sugar in norm or rate) and dibikor on 1000 two times a day. Has handed over biochemistry: all in norm or rate except alt 80, AST 90. Whether the glucofage or dibikor could give such result? I try to stick to the diet. Thank you.
Administrators
admin
Kalinka, Tamoxifen could cause poor results of liver enzyme assays. Glucophage also has a potential effect on the liver, but certainly not on such a scale as antitumor drugs, the latter are actually podsazhivayut liver.Really I do not understand what purpose after a course of chemotherapy and appointed Glyukofazh Dibikor if both write tests for sugar normal.
Visitors
Kalinka
Dear admin. Glucophage and dibicor have been prescribed for the treatment of fatty liver hepatosis. Appointments also seemed strange to me, but 2 doctors said that it cures hepatosis. Now I do not know whether to drink this or not to drink, or somehow treat the liver? And than it to treat? As I understand it is useless to go to doctors.
Administrators
admin
KalinkaIf impaired glucose tolerance is not (no so-called pre-diabetes), the steatosis liver better treat purpose hepatoprotectors on the basis of essential phospholipids (Essentiale, Essliver, etc.) or formulations based on ursodeoxycholic acid (Ursosan, Ursofalk and others) instead glyukofazh . Dibikor can be left, worse from him will not. Plus, if you have extra weight, be sure to correct nutrition.
Visitors
Kalinka
Dear admin.Thank you very much for your answer)))
Visitors
venera73
Hello, my friend advised to take weight loss Glucophage Long 750. Blood is normal, please tell me, should I take it or not?
Administrators
admin
venera73, It is necessary to pass tests for glycated hemoglobin, insulin, glucose and glucose under pressure (2 hours after a hearty breakfast). If, according to the results of these analyzes, the endocrinologist does not find signs of a violation of glucose tolerance, then Glucophage Long and similar analogues are not indicated. Also, taking this medication will not make sense if the patient has not adjusted the diet and has not been prescribed a diet.
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andrewkr
Good afternoon. My mother has type 2 diabetes. She is 76 years old. Adheres to a diet. Excess weight dropped. She took Glucophage Long 1000 mg after dinner for several months. Glucose 6-7 fasting (sometimes from 5.5) and 7.5-8.5 2 hours after eating. Tried twice a day for 500 mg of conventional glucosulphide. The result is about the same.Is it possible to take 1,500 mg of glucosulphide Long per day (750 mg after breakfast and 750 mg after dinner) at her age? According to the latest analyzes with the kidneys everything is in order (creatinine, creatinine and microalbumin urine normal, CC> 60, ultrasound of the kidneys did not do), liver tests too (bilirubin total, direct, indirect, ALT, AST, ultrasound also did not). And the same question in the usual Glucophage (500 mg after breakfast, lunch and dinner)? Is it dangerous in her case, the dosage of 1500 mg per day?
Thank you in advance.
Andrei.
Administrators
admin
andrewkr, There is no sense to take Glucophage Long 2 times a day, for that it is a prolonged action to take 1 time per day after dinner. The maximum daily dosage of Long Form is 2 grams per day. If the liver and kidneys do not suffer, and sugar norms are not achieved, then an increase in the dose of the drug taken is indicated.
Visitors
andrewkr
Thanks for the answer. Glucophage Long wanted to divide into two doses so as not to take 1500 mg at a time. As I understood from the instruction, no more than 1000 mg is needed at a time. If it is not, correct, please. And more a question, what is better - usual or prolonged action at identical dosages?
Administrators
admin
andrewkr, Some kind of mishmash you have. Dosages of the usual and long forms of glucosulphide are identical, the difference is only in the frequency of admission. There are no restrictions, except the maximum daily allowance for the prolonged form. Carefully re-read the text of the instructions above, I myself have now found all the answers to your questions there.
Visitors
andrewkr
I see. Thanks. I was confused by the fact that the long form 750 mg is taken once a day after dinner (the recommended dose from the instruction is 2 tablets, that is, 1500 mg once a day for dinner), and Long dosage form 500 mg can be as once a day after dinner , and twice a day (after breakfast and dinner). It sounds somehow strange and ambiguous: absolutely identical active substance with the same prolonged action, only tablets of different dosages. Moreover, there is also said about the dosage of 500 mg: if, taking 2000 mg once a day, blood glucose control is not achieved, then it is suggested to take 1000 mg for breakfast and the same for dinner. I thought from all of this that it is safer to take dosages above 1000 mg in two doses, not one.Especially the instruction hints that this can be more effective.
In this regard, I wanted to ask how the mother is better to take 1500 mg of glucosulphide (in terms of effectiveness and safety). And what form is better:
1. Three times a day for 500 mg of usual action after breakfast, lunch and dinner.
2. Once a day after dinner, 1500 mg of prolonged action.
3. After breakfast, 750 mg of prolonged action and the same after dinner.
You said that the prolonged action does not make sense to take twice a day, that is, you need all 1500 mg after dinner. Then the third option is dismissed and the question then is - which option is better, the usual or prolonged action, the first or second in my list? Or should we try and look at the result?
Please, understand correctly my attempt to clarify the situation. At us in a polyclinic doctors at once have registered to her medicines on the basis of derivatives sulfonylurea. There it is clear that my mother is the next element of the conveyor belt for them. And only the local therapist said: postpone such drugs at the very last. And first metformin the right dosage and intake scheme in combination with diet and physical activity.If you do not want to exhaust the pancreas for several years and spend the rest of your life on insulin. Since in type 2 diabetes, Problem 1 is to increase sensitivity to insulin, and not to stimulate increased insulin production by the pancreas. For this I am very grateful to her, I did not know all this before.
Administrators
admin
andrewkrThere are 500 mg and 750 mg doses for this, because the maximum dosage of Glucophage is knocked at 2000 mg, but how can it be properly otdosed by 750 mg tablets in no way, so for this form there will be 2 tablets a day at a maximum (1500 mg), because that the third tablet is already exceeded, and for 500 mg you can give 4 tablets per day and this will be the maximum possible daily dosage.

The correct reception of Glucophage and Metformin within 24 hours should be regulated by the patient himself and it's only in convenience. The fact that the glucose, which blocks the intake of these drugs causes fermentation and symptoms of dyspepsia in the large intestine, so if you give too much a dose of medication at a time you can get bloating, rumbling, diarrhea and other symptoms.I initially give simple forms of metformin fractional (3 times a day) strictly during meals. If tolerability is normal, you can switch to prolonged forms 2 and even once a day, but again under the control of the gastrointestinal tract.

About the sulfonylurea your doctor told the truth, leave this group of drugs at the last minute, when there will be no help from the drugs based on metformin.
Visitors
andrewkr
Many thanks for the answer :) So we will do.
Visitors
viktoriya-bakun
Good afternoon. To me of 30 years, and at body height 171 sm weight - 90 kg, that is surplus. This weight has been holding for several years, although before it was very slim. I sat on many diets, took off 4-5 kg ​​a week, then broke down and quickly returned to the previous weight. I understand that this is wrong ... I decided to turn to a gynecologist-endocrinologist. Has handed over a blood "on hormones". It was found that glycated hemoglobin increased - HbA1c = 6.37%. Insulin is within normal limits, but on the verge is 24.3 μM / ml. The doctor prescribed a drug "Glucophage 500" twice a day (with a gradual increase, starting with one tablet) for several months (until I lose weight to a comfortable state) and a low carbohydrate diet (to minimize the "fast" carbohydrates).And also warned that if you run it all, you can "dive" to diabetes! Scary ... Dear Administrator. Is it correct, in your opinion, to be treated? Can you eat cereals (porridge), potatoes, rice and at least some bran bread? Alcohol is completely contraindicated (even a glass of dry wine for the holiday)? And just like the duration of the drug - can you drink for many months, will not the addiction of the body to the drug?
Administrators
admin
viktoriya-bakunTreatment and diet are prescribed adequately. Dosing Glucophage can be selected during the treatment, while two tablets with a gradual withdrawal to the prescribed dose is sufficient. Kashi without fanaticism is possible. Potatoes are undesirable. The main thing is look at the balance of daily calories, the figures should be below the norm, so that the weight goes away. Add physical activity, if health allows. A glass of dry wine on holidays is possible, but no more than a glass and a dry one.

You will have to take it for a long time until you reach the recommended body weight parameters, then pass the tests and with a high degree of confidence I can assume that they will be normal.After this, it will be possible to discuss with the attending physician the withdrawal of Glucophage, while maintaining an adequate and balanced diet. There is no addiction to this drug.
Visitors
Svetlana Svetlana
Good afternoon. I take Glucophage 500 from 2016, 500 dosage, once a day, in the evening. She wanted to consult: she made a biochemical blood test on April 13, 2013, AST - 46 ME / l, ALT - 33, cholesterol - 5.69 mmol / l, total calcium - 2.09 mmol / ml. Appointments: atorvastatin - 20 mg in the evening (I take 10 mg), a compliment of calcium D3, karsil 1k. 3p per day (I take milk thistle). Whether it is possible to ask lech.vracha about cancellation of a glucofage, since. I feel discomfort in the right side? Also advise, how it is possible to accept in the evening atorvastatinum, lercamenum, gljukofazh, omez, kardiomagnil? Yes, even in the instructions glucose is written that you can lose weight from it, but I did not lose a gram, but only recovered by 6 kg.
Administrators
admin
Svetlana Svetlana, AST is slightly elevated, so you need to do a follow-up liver, not all indicators are done - you need to add alkaline phosphatase, bilirubin with fractions, you can look at just in case of amylase,plus to make ultrasound of the liver or abdominal cavity and then with the doctor to decide whether the liver suffers and it is required to cancel-replace Glucophage.

Lose weight can be observed dieting, limiting the caloric intake of food, and not swallowing pills.

Cholesterol is also slightly elevated, but that's what I understood against the background of the taken statins. If there were such values ​​without medication, I would still have thought of prescribing this group of drugs or not, and so it is necessary to look individually, plus the state of blood vessels, it is possible that nothing can be changed in terms of statins.

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