Ersefuril - instructions for use, analogs, reviews and release forms (suspension or syrup 4%, capsules or tablets 200 mg) of the drug for the treatment of diarrhea in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Ersefuril. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Ersefuril in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ersefuril in the presence of existing structural analogues. Use for the treatment of diarrhea without intoxication in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Ersefuril - blocks some oxidation-reduction enzyme reactions in cells of microorganisms. When used in therapeutic doses, it has a bacteriostatic effect, in high doses bactericidal action. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.
Weakly sensitive to Nifuroxazide (the active substance of the drug Ersefuril): Citrobacter spp, Enterobacter cloacae and Proteus indologenes.
Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp., Pseudomonas spp.
Does not affect saprophyte flora (does not cause dysbiosis). Resistance of microorganisms to the drug does not develop.
Composition
Nifuroxazide + excipients.
Pharmacokinetics
Ersefuril is practically not absorbed from the gastrointestinal tract, 99% of the dose taken remains in the intestine and exerts its antimicrobial effect there. Nifuroxazide is excreted by the intestine: 20% unchanged, and the rest of the nifuroxazide is chemically altered.
Indications
- acute bacterial diarrhea that occurs without deterioration of the general condition, increased body temperature, intoxication (in addition to adequate severity of rehydration diarrhea by taking fluids and electrolytes inside or, if necessary, their intravenous administration).
Forms of release
Capsules 200 mg (sometimes mistakenly called tablets).
Suspension for oral administration of 4% (sometimes mistakenly referred to as syrup or solution).
Instructions for use and dosage
Capsules
The drug is intended only for oral administration by adults or children over the age of 6 years.
Adults: 4 capsules (800 mg) per day, divided into 2-4 admission.
Children older than 6 years: 3-4 capsules (600-800 mg) per day, divided into 2-4 admission.
Duration of treatment: not more than 7 days.
Suspension
Inside, with acute diarrhea: adults - 200 mg 4 times a day, children (preferably in the form of a suspension) from 1 month to 2.5 years - 220-660 mg (1-3 measuring spoons of the suspension) in 2-3 hours , over 2.5 years - 1 measuring spoon 3 times a day. Course - no more than 7 days.
Side effect
- skin rashes;
- hives;
- angioedema;
- anaphylactic shock.
Contraindications
- hypersensitivity to nitrofuran derivatives or any excipients of the drug;
- children under 6 years (capsules);
- pregnancy;
- fructose intolerance, glucose-galactose malabsorption syndrome, or insufficiency of sucrose and isomaltase (due to the presence of sucrose in the formulation).
Application in pregnancy and lactation
Pregnancy
In animal studies, Ercefuril did not have a teratogenic effect.However, as a precaution, taking nifuroxazide during pregnancy is not recommended (insufficient clinical experience in pregnancy).
Lactation period
During the lactation period, it is possible to continue breastfeeding in the case of a short course of treatment with the drug.
Use in children
Capsules are contraindicated for children under 6 years.
special instructions
In the case of bacterial diarrhea with signs of systemic damage (worsening of the general condition, fever, symptoms of intoxication or infection) antibacterial drugs with good systemic diffusion should be used.
In the case of severe, prolonged diarrhea, severe vomiting, or with a refusal to eat, intravenous fluids and electrolytes should be considered for rehydration.
If the diarrhea persists for more than 2 days, treatment should be reviewed and the need to take fluids and electrolytes inside or their intravenous administration should be considered. The volume of the fluid to be injected and the way it is administered (inside, intravenously) should be appropriate. degree of severity of diarrhea, age and clinical condition of the patient.
Impact on the ability to drive vehicles and manage mechanisms
The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities.
Drug Interactions
Interaction with other drugs has not been observed.
Analogues of the drug Ersefuril
Structural analogs for the active substance:
- Nifuroxazide;
- Ecofuril;
- Enterofuryl.
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