Palin - instructions for use, analogs, reviews and release forms (200 mg capsules, 400 mg tablets, 200 mg vaginal suppositories) drug for the treatment of cystitis, pyelonephritis and urethritis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Palin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Palina in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Palina in the presence of existing structural analogs. Use for the treatment of cystitis, pyelonephritis and urethritis in adults, children,as well as during pregnancy and lactation.

Palin - antibacterial drug from the group of quinolones. It is bactericidal. The drug is active against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Neisseria spp., Pseudomonas aeruginosa; Gram-positive bacteria: Staphylococcus aureus.

The drug is not active against anaerobic microorganisms.

Composition

Pipemidic acid trihydrate + auxiliary substances.

Pharmacokinetics

Bioavailability is 30-60%. In the kidneys, urine and liquid of the prostate, high concentrations of pipemidic acid are created. Pipemidic acid penetrates the placental barrier. Isolated with breast milk in small amounts. Pipemidic acid is mainly excreted in the urine unchanged. In daily urine is determined 50-85% of the administered dose of the drug. Patients with impaired renal function have higher plasma concentrations of the drug than healthy volunteers.

Indications

Acute and chronic infectious-inflammatory diseases of the urinary tract caused by sensitive microorganisms:

• pyelonephritis;
• urethritis;
• cystitis;
• prostatitis.

Prevention of infections with instrumental interventions in urological and gynecological practice.

Forms of release

Capsules 200 mg.

The tablets covered with a cover of 400 mg.

Vaginal Candles 200 mg.

Instructions for use and dosing regimen

The drug is given in a dose of 200 mg every 12 hours, morning and evening before meals.

With staphylococcal infections, the interval between doses of the drug should not be more than 8 hours (200 mg 3 times a day). The course of treatment is an average of 10 days. If necessary, the course of treatment can be extended depending on the course of the disease. The duration of treatment is determined individually.

With kidney disease treatment is 3-6 weeks, with prostatitis - 6-8 weeks. During therapy, the patient is recommended to drink abundantly.

For urinary tract infections, women, along with tablets (capsules), are prescribed 1 vaginal suppository per night for 7-10 days.

Side effect

• nausea, vomiting;
• diarrhea;
• gastralgia;
• pseudomembranous colitis with severe diarrhea;
• visual impairment;
• headache;
• excitation;
• depression;
• confusion of consciousness;
• hallucinations;
• tremor;
• convulsions;
• sleep disorders;
• large convulsive seizures;
• in patients with a deficiency of glucose-6-phosphate dehydrogenase may develop hemolyticanemia;
• In elderly patients and patients with impaired renal function, thrombocytopenia may develop;
• mild itching;
• skin rash;
• Stevens-Johnson syndrome;
• photosensitization;
• superinfection.

Contraindications

• diseases of the central nervous system (neurological diseases with a lowered seizure threshold);
• porphyria;
• severe renal dysfunction (CC <10 ml / min);
• expressed violations of the liver (including cirrhosis);
• pregnancy;
• lactation (breastfeeding);
• children and adolescents up to 14 years;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Safety of Palina application during pregnancy and lactation is not studied, therefore the drug is contraindicated for use in pregnancy. If you need to use Palin during lactation, you should decide whether to stop breastfeeding.

Use in children

The drug is contraindicated in children and adolescents under 14 years.

It is not recommended to use Palin in children. Pipemidic acid accumulates in the cartilage. There are also reports of the development of muscle hypertension in newborns and children.

special instructions

With caution appoint the drug to patients who have a history of impaired cerebral circulation (including cerebral hemorrhage, spasms of cerebral vessels), convulsions; with epilepsy; patients over the age of 70 (due to an increased risk of side effects in this category of patients).

During the period of taking the drug, patients should receive a copious drink (under the control of diuresis).

Due to possible photosensitization during the Palin intake, UV irradiation should be avoided.

In connection with the possibility of developing cross-sensitivity, caution should be exercised in appointing Palina to patients who have a history of allergic reactions to quinolones.

With prolonged use of the drug should monitor the overall blood count, determine the liver and kidney function and periodically determine the sensitivity of microflora to pipemidic acid.

When using the drug, a false positive urine reaction to glucose can be noted when using a Benedict reagent or a Felling solution. It is recommended to use enzymatic reactions with glucose oxidase.

Impact on the ability to drive vehicles and manage mechanisms

When using the drug should refrain from engaging in potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

Pipemidic acid inhibits cytochrome P450 isoenzymes, which leads to a slowing of the metabolism of theophylline and Caffeine when combined with Palin.

Simultaneous administration of antacids and sucralfate may cause a decrease in the absorption of pipemidic acid, so the interval between administration of these drugs should be at least 2-3 hours.

Palin can enhance the effects of warfarin, rifampicin, cimetidine and non-steroidal anti-inflammatory drugs (NSAIDs) with simultaneous application.

With the simultaneous use of pipemidic acid with aminoglycosides, a synergism of bactericidal action is noted.

Analogues of the drug Palin

Structural analogs for the active substance:

• Vero Pipemidin;
• Pimidel;
• Pipegan;
• Pipelin;
• Pipem;
• Uropimide;
• Urotraktin.

Analogues on the therapeutic effect (means for treating cystitis):

• Alfacet;
• Amoxisar;
• Amoxicillin;
• Ampicillin;
• Biseptol;
• Brusniver;
• Witsef;
• Gentos;
• Grunamox;
• Dioxydin;
• Zinatsef;
• Zinnat;
• Indomethacin;
• Kanamycin sulfate;
• Kanefron H;
• Quipro;
• Ketoceph;
• Clamosar;
• Ligent;
• Lidaprim;
• Liprokhin;
• McMiore;
• Methyluracil;
• Microfleks;
• Monural;
• Nitroxoline;
• But-shpa;
• But-shpa fort;
• Nolycin;
• Norbaktin;
• Norillet;
• Noroksin;
• Oxamp;
• Ospamox;
• Ofloxacin;
• Palitrex;
• Piprax;
• Plivasept;
• Polyoxidonium;
• Rapiklav;
• Renor;
• Recipro;
• Sultasin;
• Taromentine;
• Tertsef;
• Urological (diuretic) collection;
• Fortum;
• Forcef;
• Furagin;
• Furadonin;
• Furamag;
• Chlorhexidine Bigluconate;
• Cefazolin;
• Cephalexin;
• Ceftriabal;
• Cefurabol;
• Ciprolet A;
• Ciprofloxacin;
• Cyston;
• The figure of OD;
• Yunidox Solutab.

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