Hepa-Merz - instructions for use, analogs, testimonials and release forms (tablets or granules (granules) 3 g, concentrate or powder injections in injectable vials) of the drug for the treatment of liver diseases in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Hepa-Mertz. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of hepatoprotector Hepa-Merz in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Gep-Merz in the presence of existing structural analogues.Use for the treatment of liver diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Hepa-Mertz - hypoammonemic drug. Has a detoxification effect, reducing the elevated level of ammonia in the body, in particular, with liver diseases. The effect of the drug is associated with its participation in the ornithine cycle of urea formation Krebs (activates the cycle, restoring the activity of liver enzymes: ornithine-carbamoyltransferase and carbamoyl-phosphate synthetase). Promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition. Helps reduce asthenic, dispensational and painful syndromes, as well as normalization of increased body weight (with steatosis and steatohepatitis).

Composition

L-ornithine L-aspartate + auxiliary substances.

Pharmacokinetics

Ornithine aspartate dissociates into its constituent components - the amino acids ornithine and aspartate, which are absorbed into the small intestine by active transport through the intestinal epithelium. It is excreted in the urine through a cycle of urea formation.

Indications

• acute and chronic liver disease, accompanied by hyperammonemia;
• hepatic encephalopathy (latent or severe), incl. in the complex therapy of mental disorders (precoma and coma);
• steatosis and steatohepatitis (of various origins);
• as a corrective additive to preparations for parenteral nutrition in patients with protein deficiency.

Forms of release

Granules for the preparation of a solution for oral administration of 3 g (sometimes mistakenly called tablets or granules).

Concentrate for the preparation of a solution for infusions (injections in ampoules for injection) (sometimes mistakenly referred to as powder).

Instructions for use and usage diagram

Granules

The drug is administered internally 1-2 packets of granules dissolved in 200 ml of liquid, 3 times a day, after meals. The course of treatment is 10 to 30 days and depends on the severity of the disease.

Ampoules

Intravenously injected up to 40 ml (4 ampoules) per day, dissolving the contents of the ampoules in 500 ml infusion solution.

In hepatic encephalopathy (depending on the degree of severity of the condition), iv injected up to 80 ml (8 ampoules) per day.

Duration of infusion, frequency and duration of treatment are determined individually. The maximum infusion rate is 5 g / h.

It is recommended to dissolve no more than 60 ml (6 ampoules) of the drug in 500 ml of the infusion solution.

Side effect

• nausea, vomiting;
• abdominal pain;
• flatulence;
• diarrhea;
• pain in the limbs;
• allergic reactions.

Contraindications

• severe renal insufficiency (serum creatinine more than 3 mg / 1 dl);
• lactation period (breastfeeding);
• children's age (due to insufficient data);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug should be used with caution in pregnancy.

The drug is contraindicated for use during breastfeeding.

special instructions

If there is nausea or vomiting, you should reduce the speed of the drug.

Impact on the ability to drive vehicles and manage mechanisms

With hepatic encephalopathy, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

The drug interaction of the Hepa-Merz drug is not described.

Analogues of the drug Gepa-Mertz

Structural analogs for the active substance:

• Ornitsetil.

Analogues for the pharmacological group (hepatoprotectors):

• L-Methionine;
• S-Adenosylmethionine;
• Antraliv;
• Berlition;
• Bondjigar;
• Brentzialle forte;
• Vitanorm;
• Gepabene;
• Hepatosan;
• Hepatofalk the plant;
• Hepafor;
• Heptor;
• Heptral;
• Heptrog;
• Glutargin;
• Glutargin alkoklin;
• Dipan;
• Covechol;
• Karsil;
• Karsil Forte;
• Kedrostat;
• Cryomelt MN;
• L-ornithine-L-aspartate;
• Laennek;
• Legalon;
• Liv 52;
• Livedoksa;
• Livolife Forte;
• Lipoic acid;
• Lipoid;
• Maxar;
• Methionine;
• Metrop;
• Milife;
• Moliksan;
• Octolipen;
• Progepar;
• Resalute Pro;
• Ropren;
• Sibektan;
• Silegon;
• Silibinin;
• Sylimar;
• Silymarin;
• Sirepard;
• Thiolipone;
• Tiotriazolin;
• Tyqveol;
• Urdoks;
• Urso 100;
• Ursodez;
• Ursodeoxycholic acid;
• Ursodex;
• Ursuliv;
• Ursor;
• Ursosan;
• Ursofalk;
• Phosphogliv;
• Phosphogliv Forte;
• Phosphontsiale;
• Hepabos;
• Holudexan;
• Exxhol;
• Erbisol;
• Eslidine;
• Essentiale N;
• Essentiale forte N;
• Essential phospholipids;
• The Essler;
• Essliver forte.

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