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Mifegin - instructions for use, reviews, analogs and forms of release (200 mg tablets) medications for medical abortion (abortion) and preparation for childbirth in women. Mechanism of action

Mifegin - instructions for use, reviews, analogs and forms of release (200 mg tablets) medications for medical abortion (abortion) and preparation for childbirth in women. Mechanism of action

In this article, you can read the instructions for using the drug Mifegin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Mifegin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mifegin in the presence of existing structural analogs. Use for medical abortion (abortion) and preparation for childbirth in women. The mechanism of action of the drug.

 

Mifegin - a synthetic steroidal anti-gestagenic drug (blocks the action of Progesterone at the level of receptors), does not possess gestagenic activity. Antagonism with glucocorticosteroids (GCS) was noted (due to competition at the level of communication with receptors).

 

Increases the contractility of the myometrium, stimulating the release of interleukin-8 in choroid-epidural cells, increasing the sensitivity of the myometrium to prostaglandins (to enhance the effect used in conjunction with the synthetic analogue of prostaglandin). As a result of the action of the drug desquamation of the decidual membrane occurs and the expulsion of the fetal egg.

 

Composition

 

Mifepristone micronized + excipients.

 

Pharmacokinetics

 

Absolute bioavailability is 69%. In plasma, Mifepristone binds 98% to proteins: albumin and acid alpha-1 glycoprotein. After the distribution phase, the excretion first occurs slowly, the concentration decreases 2 times between 12-72 hours, then more rapidly.

 

Indications

  • drug interruption of uterine pregnancy in early periods (up to 42 days amenorrhea);
  • preparation and induction of labor in term of full term pregnancy.

 

Forms of release

 

Tablets 200 mg.

 

Instructions for use and reception scheme

 

The drug should be used only in medical institutions under the supervision of a doctor.

 

For medical abortion: 600 mg of Mifegin (3 tablets of 200 mg) are taken orally once in the presence of a doctor. The patient should be supervised by medical personnel, at least 2 hours after use. After 36-48 hours after taking the drug Mifegin, the patient should report for ultrasound. After 8-14 days, a clinical examination and ultrasound monitoring is repeated, and the level of beta-chorionic hormone is determined to confirm that the miscarriage has occurred. In the absence of the effect of the drug on day 14 (incomplete abortion or continuing pregnancy), a vacuum is performed followed by a histological examination of the aspirate.

 

For the preparation and induction of labor: once 200 mg of Mifegin (1 tablet) per day in the presence of a doctor. After 24 hours, a second dose of 200 mg. After 48-72 hours, the condition of the birth canals is evaluated, and prostaglandins or oxytocin, if necessary, are administered.

 

Side effect

  • bloody discharge from the genital tract;
  • discomfort and pain in the lower abdomen;
  • exacerbation of inflammatory processes of the uterus and appendages;
  • weakness;
  • headache;
  • nausea, vomiting;
  • diarrhea;
  • dizziness;
  • hyperthermia;
  • hives;
  • vaginitis;
  • dyspepsia;
  • insomnia;
  • asthenia;
  • leg pain;
  • anxiety;
  • anemia;
  • decrease in hemoglobin (more than 2 g / dL);
  • fainting;
  • whiting.

 

Contraindications

  • adrenal insufficiency;
  • acute or chronic renal and / or liver failure;
  • porphyria;
  • long-term administration of glucocorticoids;
  • anemia;
  • violation of hemostasis (including the previous treatment with anticoagulants);
  • presence of severe extragenital pathology;
  • the presence in the anamnesis of hypersensitivity to mifepristone and / or accessory components.

 

For drug abortion:

  • suspicion of ectopic pregnancy;
  • pregnancy, not confirmed by clinical studies;
  • pregnancy for more than 42 days amenorrhea;
  • pregnancy, occurring against the background of the use of intrauterine contraceptives or after the abolition of hormonal contraception;
  • inflammatory diseases of the genital organs;
  • Smoking in women over 35 years old without prior consultation of a therapist.

 

For the preparation and induction of labor:

  • severe gestosis, preeclampsia, eclampsia;
  • premature or premature pregnancy;
  • placenta previa;
  • discrepancy between the size of the head of the fetus and the pelvis of the woman;
  • abnormal position of the fetus;
  • bloody discharge from the genital tract of an unknown etiology.

 

Application in pregnancy and lactation

 

Breastfeeding should be discontinued for 14 days after taking Mifegin.

 

special instructions

 

Patients should be informed that if there is no effect of the drug on the 10-14th day (incomplete abortion or continuing pregnancy), pregnancy should be interrupted in any other way, since it is possible to form congenital malformations in the fetus.

 

The use of the drug requires the prevention of rhesus immuno immunization and other common activities associated with abortion.

 

Patients with artificial heart valves or infective endocarditis should be treated with antibiotics when using Mifegin.

 

The drug should be used in obstetric and gynecological medical facilities that have the appropriate license, trained medical personnel and the necessary equipment.Without a prescription and relevant documents is not implemented.

 

Drug Interactions

 

Use of non-steroidal anti-inflammatory drugs should be avoided within 8-12 days after application of Mifegin.

 

Analogues of the drug Mifegin

 

Structural analogs for the active substance:

  • Agesta;
  • Ginepristone;
  • Gynestrel;
  • Wife;
  • Miropristone;
  • Mifeprex;
  • Mifepristone;
  • Pencrofton.

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Reviews (5):
Guests
Natasha
Did a medical abortion in 5,5 weeks under the supervision of a doctor taking into account ultrasound. The first three tablets of the mifegin were taken and everything is fine. The next day, bleeding began with severe pain. But everything ended well, and repeated ultrasound confirmed it, in addition to the fact that the menstrual cycle lost its way.
Guests
annabel
Tin, those who appoint this. This concerns doctors. And those fools that think that having drunk a tablet, they will easily get rid of an unnecessary pregnancy, I will say that everything is complicated with this mythgine.I hardly visited the next world, but ended up with two cleanings, because nothing good comes out after the embryo was destroyed. Get to pieces. It is better to agree to a vacuum or a traditional abortion.
Guests
Arina
And I was given birth, deceived, that for the preparation of the neck. I will say one thing - who wants to go for free in the next world, go ahead, especially if there are many contraindications!
Guests
Akdana
Where can I buy it?
Administrators
admin
Akdana, Mifegin in pharmacies do not sell, even by prescription. The risk to the life and health of patients is great and the medicine can be obtained only in the pharmacies of the hospital network as prescribed by the doctor of the same hospital.

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