Levolet R - instructions for use, analogs, antibiotic reviews and release forms (tablets 250 mg and 500 mg, injections in ampoules) for the treatment of pneumonia, prostatitis and sinusitis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Levot P. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Levolet antibiotic in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs Levot P with the presence of existing structural analogues. Use for the treatment of pneumonia, prostatitis and sinusitis in adults, children,as well as during pregnancy and lactation.

Levot P - antibacterial preparation of a group of fluoroquinolones of a wide spectrum of action. It blocks DNA-gyrase (topoisomerase 2) and topoisomerase 4, disrupts supercoiling and cross-linking of DNA gaps, suppresses DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes.

Composition

Levofloxacin hemihydrate + excipients.

Pharmacokinetics

Pharmacokinetics Levot P with a single and repeated administration of the drug is linear. The plasma profile of the concentrations of Levofloxacin after intravenous administration is similar to that of tablets. Therefore, oral and / or administration routes can be considered interchangeable. It penetrates well into organs and tissues: lungs, bronchial mucosa, sputum, organs of the genitourinary system, polymorphonuclear leukocytes, alveolar macrophages. In the liver, a small portion of levofloxacin is oxidized and / or deacetylated. It is excreted from the body mainly by the kidneys through glomerular filtration and tubular secretion.

Indications

Infectious-inflammatory diseases of mild and moderate severity caused by drug-susceptible pathogens:

• Community-acquired pneumonia (for solution for infusion);
• as part of complex therapy of drug-resistant forms of tuberculosis;
• complicated kidney and urinary tract infections, including pyelonephritis;
• uncomplicated urinary tract infections;
• prostatitis;
• septicemia / bacteremia associated with the above indications;
• intra-abdominal infections.

For tablets:

• infection of lop-organs (acute sinusitis);
• infection of the lower respiratory tract (exacerbation of chronic bronchitis);
• infections of the skin and soft tissues.

Forms of release

Tablets coated with 250 mg and 500 mg.

Solution for infusions (injections in ampoules for injections).

Instructions for use and dosage

Pills

Tablets are taken orally, before meals or in a break between meals, without chewing, squeezed with enough liquid.

Doses are determined by the nature and severity of the infection, as well as the suspected pathogen susceptibility.

Patients with normal or slightly impaired renal function (CK> 50 ml / min) the drug is recommended to be administered in the following doses.

With sinusitis - 500 mg once a day.The course of treatment is 10-14 days.

With exacerbation of chronic bronchitis - 250-500 mg once a day. The course of treatment is 10-14 days.

With community-acquired pneumonia, 500 mg 1-2 times a day. The course of treatment is 7-14 days.

In uncomplicated infections of the urinary tract - 250 mg once a day. The course of treatment is 3 days.

With complicated infections of the urinary tract (including pyelonephritis) - 250 mg once a day. The course of treatment is 7-10 days.

With prostatitis, 500 mg once a day. The course of treatment is 28 days.

With septicemia / bacteremia, 500 mg 1-2 times a day. The course of treatment is 10-14 days.

With intra-abdominal infection, 500 mg once a day. The course of treatment is 7-14 days, in combination with antibacterial drugs acting on anaerobic flora.

For skin and soft tissue infections, 250 mg 1-2 times a day or 500 mg once a day. The course of treatment is 7-14 days.

In the complex therapy of drug-resistant forms of tuberculosis - 500-1000 mg once a day. The course of treatment is up to 3 months.

The duration of treatment, depending on the course of the disease, is no more than 14 days. As with the use of other antibiotics, treatment with Levoleth R is recommended to continue for at least 48-72 hours after the normalization of body temperature or after a reliable eradication of the pathogen.

Ampoules

The drug is administered intravenously.

The dose is determined by the nature and severity of the infection, as well as the suspected pathogen susceptibility.

With community-acquired pneumonia, 500 mg 1-2 times a day. The course of treatment is 7-14 days.

In uncomplicated urinary tract infections - 250 mg once a day. The course of treatment is 3 days.

With complicated infections of the urinary tract (including pyelonephritis) - 250 mg once a day. In severe infections, the dose may be increased. The course of treatment is 7-10 days.

With bacterial prostatitis - 500 mg once a day. The course of treatment is 28 days.

With septicemia / bacteremia, 500 mg 1-2 times a day. The course of treatment is 10-14 days.

With intra-abdominal infections, 500 mg once a day. The course of treatment is 7-14 days, in combination with antibacterial drugs acting on anaerobic flora.

As part of the complex treatment of drug-resistant forms of tuberculosis - 500 mg 1-2 times a day (500-1000 mg levofloxacin per day), depending on the severity of the disease and the treatment regimen used. The course of treatment is up to 3 months.

The drug Levoleth R, in the form of a solution for infusions, is administered intravenously drip (dropper) slowly. The duration of administration of the drug at a dose of 500 mg (100 ml infusion solution / 500 mg levofloxacin) should be at least 60 minutes.

Levolet drug solution P is suitable for infusion solutions: 0.9% sodium chloride solution, 5% Dextrose (glucose), Ringer's solution 2.5% dextrose, mixed solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). The solution of the drug can not be mixed with Heparin or solutions with an alkaline reaction (for example, with sodium bicarbonate solution).

With a positive dynamics of the clinical state of the patient after a few days of treatment, it is possible to switch from an intravenous drip to an oral intake of the drug at the same dose.

The duration of treatment, depending on the course of the disease, is no more than 14 days (with the exception of bacterial prostatitis). As with the use of other antibiotics, treatment with Levoleth R is recommended to continue for at least 48-72 hours after the normalization of body temperature or after a reliable eradication of the pathogen.

Side effect

• eosinophilia, leukopenia, neutropenia, thrombocytopenia, severe agranulocytosis, hemolytic anemia, pancytopenia;
• nausea, vomiting;
• diarrhea;
• dysbiosis;
• loss of appetite;
• stomach ache;
• digestive disorders;
• Diarrhea with blood (in very rare cases it can be a sign of inflammation of the intestine or pseudomembranous colitis);
• tachycardia;
• a decrease in blood pressure;
• prolongation of the QT interval;
• headache;
• dizziness;
• drowsiness;
• sleep disorders;
• paresthesia in the hands;
• anxiety;
• states of fear;
• seizures and confusion;
• psychotic reactions such as hallucinations and depressions;
• movement disorders;
• impaired vision and hearing, smell, taste and tactile sensitivity;
• hypoglycemia (manifested by a sharp increase in appetite, nervousness, perspiration, tremor);
• impairment of renal function until acute renal failure (eg, due to allergic reactions - interstitial nephritis);
• tendon lesions (including tendonitis);
• joint and muscle pain;
• rupture of the tendon (including rupture of the Achilles tendon, which can be bilateral and manifest within 48 hours after the start of treatment);
• muscle weakness (is of particular importance for myasthenia patients);
• rhabdomyolysis;
• itching and redness of the skin;
• anaphylactic and anaphylactoid reactions (manifested by symptoms such as urticaria, bronchospasm and possible severe asphyxiation, and - in rare cases - swelling of the face, larynx);
• a sharp decrease in blood pressure;
• anaphylactic shock;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis (Lyell's syndrome);
• allergic pneumonitis;
• vasculitis;
• photosensitization;
• asthenia;
• persistent fever;
• development of superinfection.

Contraindications

• epilepsy;
• affections of tendons associated with taking quinolones in anamnesis;
• children and adolescents under 18;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to levofloxacin or other quinolones.

Application in pregnancy and lactation

The drug is contraindicated in pregnancy and lactation.

Use in children

Contraindicated: children and adolescence under 18 years.

special instructions

During treatment, sunlight and artificial ultraviolet irradiation should be avoided to avoid damage to the skin (photosensitization).

If signs of tendinitis, pseudomembranous colitis, allergic reactions Levolet P immediately canceled.

It should be borne in mind that the development of seizures is possible in patients with a history of brain injury (stroke, severe trauma), with the insufficiency of glucose-6-phosphate dehydrogenase increasing the risk of hemolysis.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

Drug Interactions

Increases T1 / 2 cyclosporine.

Completeness of absorption of levofloxacin is reduced by drugs that depress intestinal motility, sucralfate, antacid medications containing salts of aluminum and magnesium, as well as preparations containing iron salts (a break between intake of at least 2 hours is necessary).

Nonsteroidal anti-inflammatory drugs (NSAIDs), theophylline increase convulsive readiness.

Glucocorticosteroids (GCS) increase the risk of rupture of tendons.

Cimetidine and drugs that block tubular secretion slow down excretion.

Analogs of Levoleth R

Structural analogs for the active substance:

• Glevo;
• Ivacin;
• Lebel;
• Levotech;
• Levoflox;
• Levofloxabol;
• Levofloxacin;
• Levofloxacin hemihydrate;
• Levofloxacin hemihydrate;
• Leobeg;
• Leflobact;
• Lefokcin;
• Matlevo;
• OD Levoks;
• Oftakwix;
• Remedy;
• Signictsef;
• Tavanik;
• Tanflomed;
• Flexine;
• Floracid;
• Hayleflex;
• Ecology;
• Eleflox.

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