Aertal - instructions for use, analogs, reviews and release forms (100 mg tablets, suspension powder, cream or ointment) of a medicament for the treatment of lumbago, rheumatoid arthritis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Aertal. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Aerelt in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Airtal in the presence of existing structural analogs.Use for the treatment of lumbago, rheumatoid arthritis and arthrosis in adults, children, as well as during pregnancy and lactation.

Aertal non-steroidal anti-inflammatory drug (NSAID). Has anti-inflammatory, analgesic and antipyretic effect. Oppresses the synthesis of prostaglandins and, thus, affects the pathogenesis of inflammation, the onset of pain and fever.

In rheumatic diseases, the anti-inflammatory and analgesic effect of aceclofenac contributes to a significant reduction in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the patient.

Composition

Aceclofenac + auxiliary substances.

Pharmacokinetics

Quickly and completely absorbed after ingestion. Binding to albumin plasma is 99%. It penetrates into the synovial fluid, where its concentration reaches 57% of the concentration level in the plasma. It is exposed to a metabolism to an insignificant degree. Its main metabolite, found in plasma, is 4'-hydroxyacetylfenac. It is excreted by the kidneys mainly in the form of hydroxy derivatives (about 2/3 of the administered dose).

Indications

Coping inflammation and pain with:

• lumbago;
• toothache;
• humeroscapular periarthritis;
• rheumatic soft tissue damage.

Symptomatic treatment:

• rheumatoid arthritis;
• osteoarthritis (arthrosis);
• ankylosing spondylitis.

Forms of release

Tablets coated with 100 mg.

Powder for the preparation of the suspension for ingestion 100 mg.

Cream for external use (sometimes mistakenly called ointment).

Other forms, whether it be injections in ampoules or in solution, do not exist at the time of the drug description in the directory.

Instructions for use and reception scheme

Adults prescribe inside 100 mg (1 tablet) 2 times a day in the morning and in the evening.

Tablets should be swallowed whole, with enough liquid.

Side effect

• nausea, vomiting;
• diarrhea;
• pain in the epigastric region;
• intestinal colic;
• dyspepsia;
• flatulence;
• anorexia;
• constipation;
• erosive and ulcerative lesions;
• bleeding and perforation of the gastrointestinal tract (hematemesis, melena);
• stomatitis (including aphthous);
• fulminant hepatitis;
• headache;
• dizziness;
• sleep disorders (insomnia or drowsiness);
• excitation;
• sensitivity disorders;
• disorientation;
• impairment of memory, sight, hearing, taste sensations;
• noise in ears;
• convulsions;
• irritability;
• tremor;
• depression;
• anxiety;
• skin rash;
• hives;
• bronchospasm;
• eczema;
• erythroderma;
• vasculitis;
• pneumonitis;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• anaphylactic shock;
• peripheral edema;
• interstitial nephritis;
• hematuria, proteinuria;
• leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia;
• tachycardia;
• arterial hypertension;
• congestive heart failure;
• IHD.

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
• gastrointestinal bleeding or suspicion of it;
• history of bronchospasm, hives, rhinitis after taking acetylsalicylic acid or other NSAIDs (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
• period after aorto-coronary bypass surgery;
• severe hepatic impairment or active liver disease;
• disorders of hematopoiesis and coagulation;
• severe renal failure, progressive kidney disease;
• confirmed hyperkalemia;
• pregnancy;
• lactation period (breastfeeding);
• children and adolescents under 18;
• hypersensitivity to aceclofenac or other components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use during pregnancy and during breastfeeding.

Clinical data on the use of Avertal in pregnancy are absent. Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) in the third trimester of pregnancy can lead to a decrease in tone and weaker uterine contractions. The use of NSAIDs may lead to premature closure of the botulinum duct in the fetus and, possibly, to prolonged pulmonary hypertension in the newborn, delay in the onset of labor and duration of labor.

In epidemiological studies, the person did not receive data indicating embryotoxicity of NSAIDs. However, in experimental studies on rabbits with the administration of aceclofenac (10 mg / kg / day), morphological changes in the fetus were observed in some cases. Data on the presence of a teratogenic effect in rats are absent.

Data on the isolation of aceclofenac with human breast milk are absent.In experimental studies with the introduction of radioactive 14C-aceclofenac to lactating rats, no appreciable transfer of radioactivity into milk was observed.

special instructions

During the treatment with the drug should be a systematic control of the picture of peripheral blood, liver function, kidneys, examination of feces for the presence of blood.

Because of the important role of prostaglandins in maintaining renal blood flow, caution should be exercised in appointing patients with cardiac or renal insufficiency, elderly people taking diuretics, and patients with reduced BCC (for example, after extensive surgical intervention). If in such cases it is prescribed aceclofenac, it is recommended to monitor the kidney function.

In patients with hepatic insufficiency, kinetics and metabolism differ from similar processes in patients with normal liver function.

To reduce the risk of developing adverse events on the part of the gastrointestinal tract, a minimum effective dose should be used with the minimum possible short course.

Patients taking the drug should refrain from drinking alcohol.

Impact on the ability to drive vehicles and manage mechanisms

Patients suffering from vertigo and other abnormalities from the CNS during the period of taking Avertal should refrain from activities that require a high concentration of attention and speed of psychomotor reactions (driving vehicles and working with dangerous mechanisms).

Drug Interactions

When used simultaneously with the drug Aertal may increase concentrations in blood plasma digoxin, phenytoin, lithium.

When used simultaneously with the drug Aertal may reduce the effectiveness of diuretics and antihypertensive drugs.

The simultaneous use of potassium-sparing diuretics and the drug Aertal can lead to the development of hyperglycemia and hyperkalemia.

With the simultaneous administration of the drug Aertal and glucocorticosteroids (GCS) or other NSAIDs, the risk of side effects from the digestive system is increased.

With the simultaneous administration of the drug Aertal and selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) increases the risk of bleeding from the gastrointestinal tract.

Simultaneous administration of Avertal can increase the nephrotoxic effect of cyclosporine.

Against the background of the simultaneous administration of Aertal and hypoglycemic drugs, it is possible to develop both hypo- and hyperglycemia (blood glucose control is necessary).

Taking Avertal for 24 hours before or after using Methotrexate may lead to an increase in plasma methotrexate concentration and to an increase in its toxic effect.

With simultaneous use with acetylsalicylic acid, a decrease in the concentration of aceclofenac in the blood plasma is possible.

With simultaneous use of antiplatelet agents and anticoagulants, the risk of bleeding increases (regular monitoring of blood clotting indices is necessary).

Analogues of the drug Aertal

Structural analogs for the active substance:

• Asinak;
• Aceclofenac.

Analogues on the therapeutic effect (remedies for the treatment of rheumatoid arthritis):

• Azathioprine;
• Actasulide;
• Actemra;
• Amelotex;
• Arava;
• Arkoxy;
• Arthrosylen;
• Arthrotheca;
• Arthrofoon;
• Aulin;
• Bee-ksikam;
• Brustan;
• Beliefed;
• Wobenzym;
• Voltaren;
• Decortin;
• Dexazone;
• Dexalgin;
• Dexamethasone Nycomed;
• Derinat;
• Diqlovit;
• Dicloran;
• Dicloran plus;
• Diclofenac;
• Diprospan;
• Dolgit;
• Donalgin;
• Ibuklin;
• Ibuprofen;
• Immard;
• Imunofan;
• Indomethacin;
• Ketonal;
• Ketoprofen;
• Clynoril;
• Coxib;
• Consuprene;
• Xsefokam;
• Lemodus;
• MabThera;
• Meloksam;
• Meloksikam;
• Mesulide;
• The methodical;
• Midokalm;
• Mirlocks;
• Movalis;
• Movasin;
• Movix;
• Nyz;
• Naklofen;
• Nalgezin;
• Naproxen;
• Neurodiclavitis;
• Nemux;
• Nimulid;
• Novolide;
• Orgosporin;
• Plaquenil;
• Polyoxidonium;
• Polcortolone;
• Prednisolone;
• Rapten Duo;
• Revmadore;
• Tauredon;
• Tilcotyl;
• Fastum gel;
• Finalal;
• Flamax;
• Fleksen;
• Floiled;
• Hyrumat;
• Humirah;
• Celebrex;
• Cyclosporin;
• Эветрекс;
• Ecological;
• Endoxane.

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