Panzinorm - instructions for use, reviews, analogs and forms of release (capsules 10000, tablets 20000 forte) of the drug for the treatment of chronic pancreatitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Panzinorm. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists in the use of Pansinorm in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of the Pansinorm if there are existing structural analogues. Use for the treatment of chronic pancreatitis and cystic fibrosis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Panzinorm - Enzyme preparation.Compensates the insufficiency of the exocrine function of the pancreas. The effect of the drug is due to its constituent components. High lipase activity plays an important role in the treatment of maldigestii due to pancreatic enzyme deficiency. Lipase cleaves fats by hydrolysis into fatty acids and glycerol, thus contributing to their absorption and absorption of fat-soluble vitamins. Amylase splits carbohydrates into dextrins and sugars, while protease cleaves proteins.

The tablet has a protective coating, due to which the active enzymes contained in the tablet are released in the small intestine where pancreatic enzymes act.

The enzymes lipase, amylase and protease, which are part of the Pancreatin (the active substance of the Penzinorm preparation), facilitate the digestion of fats, carbohydrates and proteins, which contributes to their fuller absorption in the small intestine. Eliminates the symptoms arising from digestive disorders (feeling of heaviness and overflow of the stomach, flatulence, lack of air, shortness of breath due to the accumulation of gases in the intestines, diarrhea).Improves the process of digestion of food in children; stimulates the release of its own enzymes of the pancreas, stomach and small intestine, as well as bile.

Composition

Pancreatin + auxiliary substances.

Pharmacokinetics

Pancreatic enzymes are released from the dosage form in the alkaline medium of the small intestine. are protected from the action of gastric juice by a film membrane. A small part of the digestive enzymes are released through the intestine.

Penzinorm 10 000 is available in the form of a capsule, inside which are contained pellets, coated with a film sheath. The film membrane of the pellet protects the active enzymes from the action of the acidic environment of the stomach, which allows the enzymes to be released in the small intestine. Most of the enzymes are inactivated, as a result of autolysis and proteolysis. A small part of the digestive enzymes are released through the intestine.

Indications

• Insufficiency of the exocrine function of the pancreas (including chronic pancreatitis, cystic fibrosis);
• chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder; state after resection or irradiation of these organs,accompanied by a violation of digestion of food, flatulence, diarrhea (as part of combination therapy);
• to improve the digestion of food in patients with normal gastrointestinal function in the event of errors in nutrition, in violation of masticatory function (damage to teeth and gums, during the period of habituation to dentures), sedentary lifestyle, prolonged immobilization;
• Preparation for X-ray and ultrasound examination of the abdominal cavity organs.

Forms of release

Capsules 10000.

Tablets, coated with enteric coating 20000 Fort.

Instructions for use and dosing regimen

Capsules

The drug is taken orally during a meal or snack. Capsules should be taken whole, not liquid, squeezed with enough liquid.

The dose and duration of therapy is determined individually, depending on the age, degree of pancreatic function deficiency and diet.

Adults at the beginning of treatment are recommended to take minimum doses - 1-2 capsules 3 times a day, during each main meal (breakfast, lunch, dinner) and 1 capsule - during each snack. If necessary, the single dose is gradually increased.The effective daily dose is from 4 to 15 capsules.

The lowest effective doses should be given, especially in patients with cystic fibrosis.

Children over the age of 3 years are prescribed 1-2 capsules with meals or light snacks.

Duration of treatment can vary from a single dose or several days (if the digestive process is disturbed due to inaccuracies in the diet) to several months or years (if necessary, permanent replacement therapy).

Pills

Tablets should be taken orally, during meals, without chewing, with a sufficient amount of liquid.

The dose and duration of therapy is determined individually, depending on the age and degree of pancreatic insufficiency.

Adult Pansinorm forte is prescribed at the beginning of treatment 1 tablet 3 times a day, during each main meal. You can take Pannosinorm Fort 20 000 during a light snack. If necessary, single dose is increased 2 times. The average daily dose: 1-2 tablets 3 times.

Before x-ray and ultrasound examinations - 2 tablets 2-3 times a day for 2-3 days before the examination.

Children over the age of 3 years, the drug is prescribed in a dose of 100,000 units of Ph.Eur. per day (in terms of lipase).

The duration of treatment can vary from a single dose or for several days (if the digestive process is disturbed due to inaccuracies in the diet) to several months or years (if necessary, permanent replacement therapy).

Side effect

• hyperemia of the skin;
• skin rash;
• itching;
• sneezing;
• suffocation;
• lacrimation;
• nausea, vomiting;
• abdominal pain (including intestinal colic);
• diarrhea;
• constipation;
• perianal irritation;
• irritation of the oral mucosa;
• possibly the development of strictures (fibrous colonopathy) in the ileocecal region and in the ascending colon;
• hyperuricemia.

Contraindications

• acute pancreatitis;
• exacerbation of chronic pancreatitis;
• children under 3 years;
• children with cystic fibrosis before the age of 15;
• hypersensitivity to the pork protein or other components of the drug.

Application in pregnancy and lactation

The use of the drug Panzinorm during pregnancy and lactation (breastfeeding) is possible only in the event that,if the expected positive effect of therapy exceeds the possible risk, due to the lack of clinical data confirming the safety of the use of pancreatic enzymes in this category of patients.

Use in children

The drug should not be administered to children under the age of 15 years with concomitant cystic fibrosis. Contraindicated in children under 3 years.

special instructions

In case of cystic fibrosis, if the necessary dose of pancreatin is exceeded (more than 10 000 ED Ph. Eur lipase per 1 kg of body weight), strictures (fibrous colonopathy) in the ileocecal region and in the ascending colon can be developed. Therefore, in cystic fibrosis, the dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.

If, on the background of taking Penzinorm 10,000 capsules, symptoms of intestinal obstruction appear, fibrotic colonopathy should be excluded.

With prolonged use, iron preparations are simultaneously prescribed.

Impact on the ability to drive vehicles and manage mechanisms

It is not known about the negative impact on the ability to drive and work with other mechanisms.

Drug Interactions

With simultaneous use with pancreatin, it is possible to reduce absorption of iron preparations (clinically insignificant) and folic acid. It is recommended that folate levels and / or folic acid are monitored periodically.

The acid-resistant sheath of Penzinorm forte 20,000 tablets dissolves in the duodenum. At a low pH in the duodenum, pancreatin is not released. Simultaneous use of blockers of histamine H2-receptors (cimetidine), antacid preparations (hydrogen carbonates), inhibitors of the proton pump can lead to an increase in the effectiveness of pancreatin.

Analogues of the drug Panzinorm

Structural analogs for the active substance:

• Gastenorm forte;
• Creon;
• Mezim 20000;
• Mezim forte;
• Mikrazim;
• Pangrol;
• PanziKam;
• Panzim Forte;
• Penzinorm forte 20000;
• Pancreatym;
• Pancreatin;
• Pancreatin forte;
• Pancrelipase;
• Pantcitrate;
• Penzital;
• Festal N;
• Enzistal P;
• Hermitage.

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